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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region

  • Authors:
    • Abdul Rahman Jazieh
    • Hasan Jaafar
    • Mohammed Jaloudi
    • Rasha Saleh Mustafa
    • Kakil Rasul
    • Jamal Zekri
    • Hanaa Bamefleh
    • Ahmed Gasmelseed
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, National Guard Health Affairs, Riyadh 11426, Kingdom of Saudi Arabia, Department of Oncology, Tawam Hospital, Al Ain 15258, United Arab Emirates, King Fahd Medical City, Riyadh 11525, Kingdom of Saudi Arabia, Department of Oncology, Al Amal Hospital, Doha 3050, Qatar, Department of Oncology King Faisal Specialist and Research Center, Riyadh 11211, Kingdom of Saudi Arabia
  • Pages: 1371-1374
    |
    Published online on: September 16, 2015
       https://doi.org/10.3892/mco.2015.644
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Abstract

The aim of the present study was to determine the prevalence of epidermal growth factor receptor mutations (EGFRmut) in the Gulf region (GR) and its correlation with demographic and clinical characteristics. A multisite retrospective study was conducted, including institutions from Saudi Arabia, the United Arab Emirates and Qatar. All consecutive patients with non‑small‑cell lung cancer tested for EGFRmut were eligible. Data collected included demographic information, disease characteristics and EGFR test results. Data on 230 patients were obtained. The median age of the patients was 61 years (range, 26‑87 years); 169 patients (69.83%) were male and 204 (88.7%) were Arab. The histological subtype was adenocarcinoma in 191 (83.4%) and squamous cell carcinoma in 21 cases (9.17%). Overall, EGFRmut were detected in 66 patients (28.7%), with a prevalence of 32.46% in adenocarcinoma. No squamous cell carcinomas were found to harbor EGFRmut. The univariate and multivariate analyses revealed that female gender, non‑smoking status and adenocarcinoma subtype were significant predictors for EGFRmut. There was no difference between Arabs and non‑Arabs. In conclusion, to the best of our knowledge, this is the first multisite study to report the prevalence of EGFRmut in the GR population, which was found to be higher compared with that in Western, but lower compared with that in Far Eastern populations. Studies evaluating the efficacy of targeted therapy in this population are underway.
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Copy and paste a formatted citation
Spandidos Publications style
Jazieh AR, Jaafar H, Jaloudi M, Mustafa RS, Rasul K, Zekri J, Bamefleh H and Gasmelseed A: Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region. Mol Clin Oncol 3: 1371-1374, 2015.
APA
Jazieh, A.R., Jaafar, H., Jaloudi, M., Mustafa, R.S., Rasul, K., Zekri, J. ... Gasmelseed, A. (2015). Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region. Molecular and Clinical Oncology, 3, 1371-1374. https://doi.org/10.3892/mco.2015.644
MLA
Jazieh, A. R., Jaafar, H., Jaloudi, M., Mustafa, R. S., Rasul, K., Zekri, J., Bamefleh, H., Gasmelseed, A."Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region". Molecular and Clinical Oncology 3.6 (2015): 1371-1374.
Chicago
Jazieh, A. R., Jaafar, H., Jaloudi, M., Mustafa, R. S., Rasul, K., Zekri, J., Bamefleh, H., Gasmelseed, A."Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region". Molecular and Clinical Oncology 3, no. 6 (2015): 1371-1374. https://doi.org/10.3892/mco.2015.644
Copy and paste a formatted citation
x
Spandidos Publications style
Jazieh AR, Jaafar H, Jaloudi M, Mustafa RS, Rasul K, Zekri J, Bamefleh H and Gasmelseed A: Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region. Mol Clin Oncol 3: 1371-1374, 2015.
APA
Jazieh, A.R., Jaafar, H., Jaloudi, M., Mustafa, R.S., Rasul, K., Zekri, J. ... Gasmelseed, A. (2015). Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region. Molecular and Clinical Oncology, 3, 1371-1374. https://doi.org/10.3892/mco.2015.644
MLA
Jazieh, A. R., Jaafar, H., Jaloudi, M., Mustafa, R. S., Rasul, K., Zekri, J., Bamefleh, H., Gasmelseed, A."Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region". Molecular and Clinical Oncology 3.6 (2015): 1371-1374.
Chicago
Jazieh, A. R., Jaafar, H., Jaloudi, M., Mustafa, R. S., Rasul, K., Zekri, J., Bamefleh, H., Gasmelseed, A."Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region". Molecular and Clinical Oncology 3, no. 6 (2015): 1371-1374. https://doi.org/10.3892/mco.2015.644
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