Association between shortage of energy supply and nuclear gene mutations leading to carcinomatous transformation (Review)

Du,Jianping

doi:10.3892/mco.2015.656

January-2016 Volume 4 Issue 1

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January-2016 Volume 4 Issue 1

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Review

Association between shortage of energy supply and nuclear gene mutations leading to carcinomatous transformation (Review)

Authors:
- Jianping Du
View Affiliations / Copyright

Affiliations: Department of Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui 230001, P.R. China
Pages: 11-12
|
Published online on: October 16, 2015

https://doi.org/10.3892/mco.2015.656
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Abstract

Anaerobic bacteria use glycolysis, an oxygen‑independent metabolic pathway, whereas energy metabolism in the evolved eukaryotic cell is performed via oxidative phosphorylation, with all eukaryotic cell activities depending upon high energy consumption. However, in cancer cells evolving from eukaryotic cells, the energy metabolism switches from oxidative phosphorylation to glycolysis. The shortage of energy supply induces cancer cells to acquire specific characteristics. base pair renewal is the most energy‑consuming process in the cell, and shortage of energy supply may lead to errors in this process; the more prominent the shortage in energy supply, the more errors are likely to occur in base pair renewal, resulting in gene mutations and expression of cancer cell characteristics. Thus, shortage of energy supply is associated with carcinomatous transformation.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Association between shortage of energy supply and nuclear gene mutations leading to carcinomatous transformation (Review)

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