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Article

Clinical outcome of immunotherapy with dendritic cell vaccine and cytokine‑induced killer cell therapy in hepatobiliary and pancreatic cancer

  • Authors:
    • Lihong Zhang
    • Wei Zhu
    • Jiali Li
    • Xuejing Yang
    • Yanjie Ren
    • Jingxiu Niu
    • Yan Pang
  • View Affiliations / Copyright

    Affiliations: School of Medicine, NanKai University, Tianjin 300071, P.R. China, Graduate School of Tianjin Medical University, Tianjin 300070, P.R. China, Department of Oncology, Tianjin Union Medicine Centre, Tianjin 300121, P.R. China
  • Pages: 129-133
    |
    Published online on: October 23, 2015
       https://doi.org/10.3892/mco.2015.660
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Abstract

The aim of this study was to determine the therapeutic effects of adoptive immunotherapy following dendritic cell (DC) vaccine and cytokine‑induced killer (CIK) cell therapy and evaluate its cytotoxicity, survival benefits and quality of life (QOL) changes in patients with hepatobiliary and pancreatic cancer (HPC). We performed a retrospective analysis of 407 clinical cases, including 77 patients with HPC who received immunotherapy with DC vaccine and CIK cells (I group) and 330 patients with similar characteristics who underwent baseline treatment but did not receive immunotherapy [non‑immunotherapy (NI) group)] as the control group. After a follow‑up period of 294±207.5 days, the median survival time (MST) of the two groups was compared using the Kaplan‑Meier method. In the I group, 61% of the patients developed a positive, delayed‑type hypersensitivity response and 65% of the patients exhibited an improvement in QOL. The most notable adverse events included fever (28%), insomnia (25%), anorexia (17%), skin rash (12%) and arthralgia (31%). No severe toxicities were observed in patients in the I group; in addition, the MST was significantly longer in the I group compared with that in the NI group (P=0.014). Thus, the DC vaccine and CIK cell therapy was associated with mild adverse effects, but was able to induce an immune response and effectively eliminate tumor cells, thereby improving the QOL and prolonging the MST of the patients.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Zhu W, Li J, Yang X, Ren Y, Niu J and Pang Y: Clinical outcome of immunotherapy with dendritic cell vaccine and cytokine‑induced killer cell therapy in hepatobiliary and pancreatic cancer. Mol Clin Oncol 4: 129-133, 2016.
APA
Zhang, L., Zhu, W., Li, J., Yang, X., Ren, Y., Niu, J., & Pang, Y. (2016). Clinical outcome of immunotherapy with dendritic cell vaccine and cytokine‑induced killer cell therapy in hepatobiliary and pancreatic cancer. Molecular and Clinical Oncology, 4, 129-133. https://doi.org/10.3892/mco.2015.660
MLA
Zhang, L., Zhu, W., Li, J., Yang, X., Ren, Y., Niu, J., Pang, Y."Clinical outcome of immunotherapy with dendritic cell vaccine and cytokine‑induced killer cell therapy in hepatobiliary and pancreatic cancer". Molecular and Clinical Oncology 4.1 (2016): 129-133.
Chicago
Zhang, L., Zhu, W., Li, J., Yang, X., Ren, Y., Niu, J., Pang, Y."Clinical outcome of immunotherapy with dendritic cell vaccine and cytokine‑induced killer cell therapy in hepatobiliary and pancreatic cancer". Molecular and Clinical Oncology 4, no. 1 (2016): 129-133. https://doi.org/10.3892/mco.2015.660
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Zhu W, Li J, Yang X, Ren Y, Niu J and Pang Y: Clinical outcome of immunotherapy with dendritic cell vaccine and cytokine‑induced killer cell therapy in hepatobiliary and pancreatic cancer. Mol Clin Oncol 4: 129-133, 2016.
APA
Zhang, L., Zhu, W., Li, J., Yang, X., Ren, Y., Niu, J., & Pang, Y. (2016). Clinical outcome of immunotherapy with dendritic cell vaccine and cytokine‑induced killer cell therapy in hepatobiliary and pancreatic cancer. Molecular and Clinical Oncology, 4, 129-133. https://doi.org/10.3892/mco.2015.660
MLA
Zhang, L., Zhu, W., Li, J., Yang, X., Ren, Y., Niu, J., Pang, Y."Clinical outcome of immunotherapy with dendritic cell vaccine and cytokine‑induced killer cell therapy in hepatobiliary and pancreatic cancer". Molecular and Clinical Oncology 4.1 (2016): 129-133.
Chicago
Zhang, L., Zhu, W., Li, J., Yang, X., Ren, Y., Niu, J., Pang, Y."Clinical outcome of immunotherapy with dendritic cell vaccine and cytokine‑induced killer cell therapy in hepatobiliary and pancreatic cancer". Molecular and Clinical Oncology 4, no. 1 (2016): 129-133. https://doi.org/10.3892/mco.2015.660
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