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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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January-2016 Volume 4 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Expression of metabotropic glutamate receptor 4 in osteosarcoma

  • Authors:
    • Shuo Wang
    • Xing Wei
    • Bingyao Chen
    • Min Zhao
    • Guangze Song
    • Zengliang Zhang
    • Nan Li
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Oncology, the First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing 100048, P.R. China, Department of Pathology, the First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing 100048, P.R. China
  • Pages: 65-69
    |
    Published online on: October 23, 2015
       https://doi.org/10.3892/mco.2015.661
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Abstract

Metabotropic glutamate receptor 4 (mGluR4) has been associated with the pathogenesis of osteosarcoma. The aim of this study was to investigate mGluR4 expression and its clinical significance in osteosarcoma patients. mGluR4 expression was investigated using immunohistochemistry (IHC) in 58 osteosarcomas and 32 giant‑cell tumors of bone. The correlations between mGluR4 expression and clinicopathological characteristics were analyzed with the Chi‑squared test and survival curves were generated using the Kaplan‑Meier method. The IHC results demonstrated that 20.69% (12/58) of the osteosarcomas and 43.75% (14/32) of the giant‑cell tumors were mGluR4‑positive. The statistical analysis revealed that mGluR4 expression was correlated with gender, age, Enneking stage and tumor volume in osteosarcomas (P<0.05). In the multivariate stepwise Cox regression analysis, Enneking stage was found to be statistically significantly associated with survival (P<0.05) and the survival analysis demonstrated that the survival probability was significantly higher in patients with higher mGluR4 expression compared with those with lower expression (P<0.05). Therefore, mGluR4 expression may be used to estimate the prognosis of osteosarcoma patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wang S, Wei X, Chen B, Zhao M, Song G, Zhang Z and Li N: Expression of metabotropic glutamate receptor 4 in osteosarcoma. Mol Clin Oncol 4: 65-69, 2016.
APA
Wang, S., Wei, X., Chen, B., Zhao, M., Song, G., Zhang, Z., & Li, N. (2016). Expression of metabotropic glutamate receptor 4 in osteosarcoma. Molecular and Clinical Oncology, 4, 65-69. https://doi.org/10.3892/mco.2015.661
MLA
Wang, S., Wei, X., Chen, B., Zhao, M., Song, G., Zhang, Z., Li, N."Expression of metabotropic glutamate receptor 4 in osteosarcoma". Molecular and Clinical Oncology 4.1 (2016): 65-69.
Chicago
Wang, S., Wei, X., Chen, B., Zhao, M., Song, G., Zhang, Z., Li, N."Expression of metabotropic glutamate receptor 4 in osteosarcoma". Molecular and Clinical Oncology 4, no. 1 (2016): 65-69. https://doi.org/10.3892/mco.2015.661
Copy and paste a formatted citation
x
Spandidos Publications style
Wang S, Wei X, Chen B, Zhao M, Song G, Zhang Z and Li N: Expression of metabotropic glutamate receptor 4 in osteosarcoma. Mol Clin Oncol 4: 65-69, 2016.
APA
Wang, S., Wei, X., Chen, B., Zhao, M., Song, G., Zhang, Z., & Li, N. (2016). Expression of metabotropic glutamate receptor 4 in osteosarcoma. Molecular and Clinical Oncology, 4, 65-69. https://doi.org/10.3892/mco.2015.661
MLA
Wang, S., Wei, X., Chen, B., Zhao, M., Song, G., Zhang, Z., Li, N."Expression of metabotropic glutamate receptor 4 in osteosarcoma". Molecular and Clinical Oncology 4.1 (2016): 65-69.
Chicago
Wang, S., Wei, X., Chen, B., Zhao, M., Song, G., Zhang, Z., Li, N."Expression of metabotropic glutamate receptor 4 in osteosarcoma". Molecular and Clinical Oncology 4, no. 1 (2016): 65-69. https://doi.org/10.3892/mco.2015.661
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