Expression of metabotropic glutamate receptor 4 in osteosarcoma

  • Authors:
    • Shuo Wang
    • Xing Wei
    • Bingyao Chen
    • Min Zhao
    • Guangze Song
    • Zengliang Zhang
    • Nan Li
  • View Affiliations

  • Published online on: October 23, 2015     https://doi.org/10.3892/mco.2015.661
  • Pages: 65-69
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Abstract

Metabotropic glutamate receptor 4 (mGluR4) has been associated with the pathogenesis of osteosarcoma. The aim of this study was to investigate mGluR4 expression and its clinical significance in osteosarcoma patients. mGluR4 expression was investigated using immunohistochemistry (IHC) in 58 osteosarcomas and 32 giant‑cell tumors of bone. The correlations between mGluR4 expression and clinicopathological characteristics were analyzed with the Chi‑squared test and survival curves were generated using the Kaplan‑Meier method. The IHC results demonstrated that 20.69% (12/58) of the osteosarcomas and 43.75% (14/32) of the giant‑cell tumors were mGluR4‑positive. The statistical analysis revealed that mGluR4 expression was correlated with gender, age, Enneking stage and tumor volume in osteosarcomas (P<0.05). In the multivariate stepwise Cox regression analysis, Enneking stage was found to be statistically significantly associated with survival (P<0.05) and the survival analysis demonstrated that the survival probability was significantly higher in patients with higher mGluR4 expression compared with those with lower expression (P<0.05). Therefore, mGluR4 expression may be used to estimate the prognosis of osteosarcoma patients.
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January-2016
Volume 4 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Wang S, Wei X, Chen B, Zhao M, Song G, Zhang Z and Li N: Expression of metabotropic glutamate receptor 4 in osteosarcoma. Mol Clin Oncol 4: 65-69, 2016
APA
Wang, S., Wei, X., Chen, B., Zhao, M., Song, G., Zhang, Z., & Li, N. (2016). Expression of metabotropic glutamate receptor 4 in osteosarcoma. Molecular and Clinical Oncology, 4, 65-69. https://doi.org/10.3892/mco.2015.661
MLA
Wang, S., Wei, X., Chen, B., Zhao, M., Song, G., Zhang, Z., Li, N."Expression of metabotropic glutamate receptor 4 in osteosarcoma". Molecular and Clinical Oncology 4.1 (2016): 65-69.
Chicago
Wang, S., Wei, X., Chen, B., Zhao, M., Song, G., Zhang, Z., Li, N."Expression of metabotropic glutamate receptor 4 in osteosarcoma". Molecular and Clinical Oncology 4, no. 1 (2016): 65-69. https://doi.org/10.3892/mco.2015.661