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Article

Management of the N0 neck in recurrent laryngeal squamous cell carcinoma

  • Authors:
    • Pei‑Jing Li
    • Wei‑Han Hu
    • Ting Jin
  • View Affiliations / Copyright

    Affiliations: Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, P.R. China, Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
  • Pages: 70-76
    |
    Published online on: October 29, 2015
       https://doi.org/10.3892/mco.2015.663
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Abstract

The most effective therapeutic approach for the node-negative (N0) neck in patients with recurrent laryngeal squamous cell carcinoma (SCC) remains a subject of dispute. In the present study, the records of 163 patients with recurrent laryngeal SCC were retrospectively reviewed. All patients had a N0 neck at recurrence. At the time of recurrence, the N0 neck was managed using a wait‑and‑see strategy (observation group) or treatment (treatment group). A total of 125 (76.7%) patients accepted the wait‑and‑see strategy and 38 (23.3%) patients underwent treatments, including surgery, radiotherapy and/or chemotherapy. The Kaplan‑Meier method with the computation of log‑rank was used for analysis of survival. The t‑test, χ2 test or Fisher's exact test was used for comparisons of non‑survival data in the groups. P<0.05 was considered to indicate a statistically significant difference in the two‑sided tests. The 3‑ and 5‑year overall survival rates after recurrence were 64.5 and 54.6% for the observation group, and 49.9 and 42.5% for the treatment group, respectively (P=0.011). The present study suggests that a wait‑and‑see policy is a satisfactory management option for the N0 neck in recurrent laryngeal SCC.
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1 

Argiris A, Karamouzis MV, Raben D and Ferris RL: Head and neck cancer. Lancet. 371:1695–1709. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Marshak G, Brenner B, Shvero J, Shapira J, Ophir D, Hochman I, Marshak G, Sulkes A and Rakowsky E: Prognostic factors for local control of early glottic cancer: The Rabin medical center retrospective study on 207 patients. Int J Radiat Oncol Biol Phys. 43:1009–1013. 1999. View Article : Google Scholar : PubMed/NCBI

4 

Barthel SW and Esclamado RM: Primary radiation therapy for early glottic cancer. Otolaryngol Head Neck Surg. 124:35–39. 2001. View Article : Google Scholar : PubMed/NCBI

5 

McLaughlin MP, Parsons JT, Fein DA, Stringer SP, Cassisi NJ, Mendenhall WM and Million RR: Salvage surgery after radiotherapy failure in T1-T2 squamous cell carcinoma of the glottic larynx. Head Neck. 18:229–235. 1996. View Article : Google Scholar : PubMed/NCBI

6 

Lefebvre JL, Chevalier D, Luboinski B, Kirkpatrick A, Collette L and Sahmoud T: Larynx preservation in pyriform sinus cancer: Preliminary results of a european organization for research and treatment of cancer phase III trial. EORTC head and neck cancer cooperative group. J Natl Cancer Inst. 88:890–899. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Berger G, Harwood AR, Bryce DP and van Nostrand AW: Primary subglottic carcinoma masquerading clinically as T1 glottic carcinoma-a report of nine cases. J Otolaryngol. 14:1–6. 1985.PubMed/NCBI

8 

Strome SE, Robey TC, Devaney KO, Krause CJ and Hogikyan ND: Subglottic carcinoma: Review of a series and characterization of its patterns of spread. Ear Nose Throat J. 78:622–624. 1999.PubMed/NCBI

9 

Rübe C, Micke O, Grevers G, Rohloff R, Kaufmann H, Busch M and Willich N: Primary radiotherapy of laryngeal carcinoma. An analysis of the therapeutic results and of the the relapse behavior in 283 patients. Strahlentherapie Onkol. 173:83–90. 1997. View Article : Google Scholar

10 

Agra IM, Ferlito A, Takes RP, Silver CE, Olsen KD, Stoeckli SJ, Strojan P, Rodrigo JP, Gonçalves Filho J, Genden EM, et al: Diagnosis and treatment of recurrent laryngeal cancer following initial nonsurgical therapy. Head Neck. 34:727–735. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Li M, Lorenz RR, Khan MJ, Burkey BB, Adelstein DJ, Greskovich JF Jr, Koyfman SA and Scharpf J: Salvage laryngectomy in patients with recurrent laryngeal cancer in the setting of nonoperative treatment failure. Otolaryngol Head Neck Surg. 149:245–251. 2013. View Article : Google Scholar : PubMed/NCBI

12 

van der Putten L, de Bree R, Kuik DJ, Rietveld DH, Buter J, Eerenstein SE and Leemans CR: Salvage laryngectomy: Oncological and functional outcome. Oral Oncol. 47:296–301. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Brenner B, Marshak G, Sulkes A and Rakowsky E: Prognosis of patients with recurrent laryngeal carcinoma. Head Neck. 23:531–535. 2001. View Article : Google Scholar : PubMed/NCBI

14 

Yuen AP, Wei WI, Hui Y and Ho WK: Comprehensive analysis of pharyngeal recurrence of laryngeal carcinoma after total laryngectomy. Am J Otolaryngol. 17:380–385. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Kasperts N, Slotman B, Leemans CR and Langendijk JA: A review on re-irradiation for recurrent and second primary head and neck cancer. Oral Oncol. 41:225–243. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Davidson J, Keane T, Brown D, Freeman J, Gullane P, Irish J, Rotstein L, Pintilie M and Cummings B: Surgical salvage after radiotherapy for advanced laryngopharyngeal carcinoma. Arch Otolaryngol Head Neck Surg. 123:420–424. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Soo KC, Shah JP, Gopinath KS, Gerold FP, Jaques DP and Strong EW: Analysis of prognostic variables and results after supraglottic partial laryngectomy. Am J Surg. 156:301–305. 1988. View Article : Google Scholar : PubMed/NCBI

18 

Yuen AP, Ho CM, Wei WI and Lam LK: Prognosis of recurrent laryngeal carcinoma after laryngectomy. Head Neck. 17:526–530. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Stoeckli SJ, Pawlik AB, Lipp M, Huber A and Schmid S: Salvage surgery after failure of nonsurgical therapy for carcinoma of the larynx and hypopharynx. Arch Otolaryngol Head Neck Surg. 126:1473–1477. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Jørgensen K, Godballe C, Hansen O and Bastholt L: Cancer of the larynx-treatment results after primary radiotherapy with salvage surgery in a series of 1005 patients. Acta Oncol. 41:69–76. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Parsons JT, Mendenhall WM, Stringer SP, Cassisi NJ and Million RR: Salvage surgery following radiation failure in squamous cell carcinoma of the supraglottic larynx. Int J Radiat Oncol Biol Phys. 32:605–609. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Mendenhall WM, Parsons JT, Brant TA, Stringer SP, Cassisi NJ and Million RR: Is elective neck treatment indicated for T2N0 squamous cell carcinoma of the glottic larynx? Radiother Oncol. 14:199–202. 1989. View Article : Google Scholar : PubMed/NCBI

23 

Yuen AP, Wei WI and Wong SH: Critical appraisal of watchful waiting policy in the management of N0 neck of advanced laryngeal carcinoma. Arch Otolaryngol Head Neck Surg. 122:742–745. 1996. View Article : Google Scholar : PubMed/NCBI

24 

Temam S, Koka V, Mamelle G, Julieron M, Carmantrant R, Marandas P, Janot F, Bourhis J and Luboinski B: Treatment of the N0 neck during salvage surgery after radiotherapy of head and neck squamous cell carcinoma. Head Neck. 27:653–658. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Wax MK and Touma BJ: Management of the N0 neck during salvage laryngectomy. Laryngoscope. 109:4–7. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Yao M, Roebuck JC, Holsinger FC and Myers JN: Elective neck dissection during salvage laryngectomy. Am J Otolaryngol. 26:388–392. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Farrag TY, Lin FR, Cummings CW, Koch WM, Flint PW, Califano JA, Broussard J, Bajaj G and Tufano RP: Neck management in patients undergoing postradiotherapy salvage laryngeal surgery for recurrent/persistent laryngeal cancer. Laryngoscope. 116:1864–1866. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Bohannon IA, Desmond RA, Clemons L, Magnuson JS, Carroll WR and Rosenthal EL: Management of the No neck in recurrent laryngeal squamous cell carcinoma. Laryngoscope. 120:58–61. 2010.PubMed/NCBI

29 

Yao M, Smith RB, Graham MM, Hoffman HT, Tan H, Funk GF, Graham SM, Chang K, Dornfeld KJ, Menda Y and Buatti JM: The role of FDG PET in management of neck metastasis from head-and-neck cancer after definitive radiation treatment. Int J Radiat Oncol Biol Phys. 63:991–999. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Koss SL, Russell MD, Leem TH, Schiff BA and Smith RV: Occult nodal disease in patients with failed laryngeal preservation undergoing surgical salvage. Laryngoscope. 124:421–428. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Svensson H and Möller TR: SBU Survey Group: Developments in radiotherapy. Acta Oncol. 42:430–442. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li PJ, Hu WH and Jin T: Management of the N0 neck in recurrent laryngeal squamous cell carcinoma. Mol Clin Oncol 4: 70-76, 2016.
APA
Li, P., Hu, W., & Jin, T. (2016). Management of the N0 neck in recurrent laryngeal squamous cell carcinoma. Molecular and Clinical Oncology, 4, 70-76. https://doi.org/10.3892/mco.2015.663
MLA
Li, P., Hu, W., Jin, T."Management of the N0 neck in recurrent laryngeal squamous cell carcinoma". Molecular and Clinical Oncology 4.1 (2016): 70-76.
Chicago
Li, P., Hu, W., Jin, T."Management of the N0 neck in recurrent laryngeal squamous cell carcinoma". Molecular and Clinical Oncology 4, no. 1 (2016): 70-76. https://doi.org/10.3892/mco.2015.663
Copy and paste a formatted citation
x
Spandidos Publications style
Li PJ, Hu WH and Jin T: Management of the N0 neck in recurrent laryngeal squamous cell carcinoma. Mol Clin Oncol 4: 70-76, 2016.
APA
Li, P., Hu, W., & Jin, T. (2016). Management of the N0 neck in recurrent laryngeal squamous cell carcinoma. Molecular and Clinical Oncology, 4, 70-76. https://doi.org/10.3892/mco.2015.663
MLA
Li, P., Hu, W., Jin, T."Management of the N0 neck in recurrent laryngeal squamous cell carcinoma". Molecular and Clinical Oncology 4.1 (2016): 70-76.
Chicago
Li, P., Hu, W., Jin, T."Management of the N0 neck in recurrent laryngeal squamous cell carcinoma". Molecular and Clinical Oncology 4, no. 1 (2016): 70-76. https://doi.org/10.3892/mco.2015.663
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