Management of the N0 neck in recurrent laryngeal squamous cell carcinoma

Li,Pei‑Jing; Hu,Wei‑Han; Jin,Ting

doi:10.3892/mco.2015.663

Management of the N0 neck in recurrent laryngeal squamous cell carcinoma

Authors:
- Pei‑Jing Li
- Wei‑Han Hu
- Ting Jin
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Affiliations: Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou 510060, P.R. China, Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
Published online on: October 29, 2015 https://doi.org/10.3892/mco.2015.663
Pages: 70-76

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Abstract

The most effective therapeutic approach for the node-negative (N0) neck in patients with recurrent laryngeal squamous cell carcinoma (SCC) remains a subject of dispute. In the present study, the records of 163 patients with recurrent laryngeal SCC were retrospectively reviewed. All patients had a N0 neck at recurrence. At the time of recurrence, the N0 neck was managed using a wait‑and‑see strategy (observation group) or treatment (treatment group). A total of 125 (76.7%) patients accepted the wait‑and‑see strategy and 38 (23.3%) patients underwent treatments, including surgery, radiotherapy and/or chemotherapy. The Kaplan‑Meier method with the computation of log‑rank was used for analysis of survival. The t‑test, χ2 test or Fisher's exact test was used for comparisons of non‑survival data in the groups. P<0.05 was considered to indicate a statistically significant difference in the two‑sided tests. The 3‑ and 5‑year overall survival rates after recurrence were 64.5 and 54.6% for the observation group, and 49.9 and 42.5% for the treatment group, respectively (P=0.011). The present study suggests that a wait‑and‑see policy is a satisfactory management option for the N0 neck in recurrent laryngeal SCC.

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