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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Feasibility of intensity-modulated radiotherapy combined with gemcitabine and S-1 for patients with pancreatic cancer

  • Authors:
    • Norifumi Kennoki
    • Hidetsugu Nakayama
    • Yuichi Nagakawa
    • Yuichi Hosokawa
    • Tomohiro Itonaga
    • Yu Tajima
    • Sachica Shiraishi
    • Ryuji Mikami
    • Akihiko Tsuchida
    • Koichi Tokuuye
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Tokyo Medical University, Shinjyuku, Tokyo 160‑0023, Japan, Third Department of Surgery, Tokyo Medical University, Shinjyuku, Tokyo 160‑0023, Japan
  • Pages: 43-46
    |
    Published online on: October 29, 2015
       https://doi.org/10.3892/mco.2015.664
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Abstract

The aim of the present study was to establish whether intensity-modulated radiotherapy (IMRT) with concurrent gemcitabine and S-1 is a feasible treatment option for patients with locally advanced pancreatic ductal adenocarcinoma. Patients with pancreatic ductal adenocarcinoma were prospectively enrolled. An IMRT dose of 50.4 Gy in 28 fractions with concurrent gemcitabine at a dose of 600 mg/m2 and S‑1 at a dose of 60 mg were administrated. Adverse events and associated dosimetric factors were assessed. Between February 2012 and January 2014, 17 patients with borderline resectable and 4 with unresectable pancreatic cancer were enrolled. None of the patients experienced grade 3 or worse nausea and vomiting. The planning target volume (≥200 vs. <200 ml) was a statistically significant predictive factor for neutrocytopenia (≥500 vs. 500/µl, P=0.02). Concurrent IMRT with gemcitabine and S‑1 for patients with locally advanced pancreatic cancer is feasible, with tolerable hematological toxicities and low gastrointestinal toxicities.
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Copy and paste a formatted citation
Spandidos Publications style
Kennoki N, Nakayama H, Nagakawa Y, Hosokawa Y, Itonaga T, Tajima Y, Shiraishi S, Mikami R, Tsuchida A, Tokuuye K, Tokuuye K, et al: Feasibility of intensity-modulated radiotherapy combined with gemcitabine and S-1 for patients with pancreatic cancer. Mol Clin Oncol 4: 43-46, 2016.
APA
Kennoki, N., Nakayama, H., Nagakawa, Y., Hosokawa, Y., Itonaga, T., Tajima, Y. ... Tokuuye, K. (2016). Feasibility of intensity-modulated radiotherapy combined with gemcitabine and S-1 for patients with pancreatic cancer. Molecular and Clinical Oncology, 4, 43-46. https://doi.org/10.3892/mco.2015.664
MLA
Kennoki, N., Nakayama, H., Nagakawa, Y., Hosokawa, Y., Itonaga, T., Tajima, Y., Shiraishi, S., Mikami, R., Tsuchida, A., Tokuuye, K."Feasibility of intensity-modulated radiotherapy combined with gemcitabine and S-1 for patients with pancreatic cancer". Molecular and Clinical Oncology 4.1 (2016): 43-46.
Chicago
Kennoki, N., Nakayama, H., Nagakawa, Y., Hosokawa, Y., Itonaga, T., Tajima, Y., Shiraishi, S., Mikami, R., Tsuchida, A., Tokuuye, K."Feasibility of intensity-modulated radiotherapy combined with gemcitabine and S-1 for patients with pancreatic cancer". Molecular and Clinical Oncology 4, no. 1 (2016): 43-46. https://doi.org/10.3892/mco.2015.664
Copy and paste a formatted citation
x
Spandidos Publications style
Kennoki N, Nakayama H, Nagakawa Y, Hosokawa Y, Itonaga T, Tajima Y, Shiraishi S, Mikami R, Tsuchida A, Tokuuye K, Tokuuye K, et al: Feasibility of intensity-modulated radiotherapy combined with gemcitabine and S-1 for patients with pancreatic cancer. Mol Clin Oncol 4: 43-46, 2016.
APA
Kennoki, N., Nakayama, H., Nagakawa, Y., Hosokawa, Y., Itonaga, T., Tajima, Y. ... Tokuuye, K. (2016). Feasibility of intensity-modulated radiotherapy combined with gemcitabine and S-1 for patients with pancreatic cancer. Molecular and Clinical Oncology, 4, 43-46. https://doi.org/10.3892/mco.2015.664
MLA
Kennoki, N., Nakayama, H., Nagakawa, Y., Hosokawa, Y., Itonaga, T., Tajima, Y., Shiraishi, S., Mikami, R., Tsuchida, A., Tokuuye, K."Feasibility of intensity-modulated radiotherapy combined with gemcitabine and S-1 for patients with pancreatic cancer". Molecular and Clinical Oncology 4.1 (2016): 43-46.
Chicago
Kennoki, N., Nakayama, H., Nagakawa, Y., Hosokawa, Y., Itonaga, T., Tajima, Y., Shiraishi, S., Mikami, R., Tsuchida, A., Tokuuye, K."Feasibility of intensity-modulated radiotherapy combined with gemcitabine and S-1 for patients with pancreatic cancer". Molecular and Clinical Oncology 4, no. 1 (2016): 43-46. https://doi.org/10.3892/mco.2015.664
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