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Review

Impact of single‑nucleotide polymorphisms on radiation pneumonitis in cancer patients (Review)

  • Authors:
    • Cheng‑Xian Guo
    • Jing Wang
    • Li‑Hua Huang
    • Jin-Gao Li
    • Xiang Chen
  • View Affiliations / Copyright

    Affiliations: Center of Clinical Pharmacology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Medical College of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Center for Experimental Medical Research, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, Jiangxi 330029, P.R. China, Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan 410078, P.R. China
  • Pages: 3-10
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    Published online on: October 30, 2015
       https://doi.org/10.3892/mco.2015.666
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Abstract

Radiation pneumonitis (RP) is one of the most important dose‑limiting toxicities in the radiotherapy of thoracic tumors, which reduces the rate of local tumor control and overall survival and severely affects the patients' quality of life. Single‑nucleotide polymorphisms (SNPs) have recently attracted increasing attention as biomarkers for predicting the development of RP. SNPs in inflammation‑related, DNA repair‑related, stress response‑related and angiogenesis‑related genes were proved to be associated with RP, with different underlying mechanisms. Radiogenomics focuses on the differences in radiosensitivity caused by gene sequence variation, which may prove helpful in investigating the abovementioned associations. In this review, we aimed to investigate the associations between RP and SNPs reported in recent studies and highlight the main content and prospects of radiogenomics.
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Copy and paste a formatted citation
Spandidos Publications style
Guo CX, Wang J, Huang LH, Li J and Chen X: Impact of single‑nucleotide polymorphisms on radiation pneumonitis in cancer patients (Review). Mol Clin Oncol 4: 3-10, 2016.
APA
Guo, C., Wang, J., Huang, L., Li, J., & Chen, X. (2016). Impact of single‑nucleotide polymorphisms on radiation pneumonitis in cancer patients (Review). Molecular and Clinical Oncology, 4, 3-10. https://doi.org/10.3892/mco.2015.666
MLA
Guo, C., Wang, J., Huang, L., Li, J., Chen, X."Impact of single‑nucleotide polymorphisms on radiation pneumonitis in cancer patients (Review)". Molecular and Clinical Oncology 4.1 (2016): 3-10.
Chicago
Guo, C., Wang, J., Huang, L., Li, J., Chen, X."Impact of single‑nucleotide polymorphisms on radiation pneumonitis in cancer patients (Review)". Molecular and Clinical Oncology 4, no. 1 (2016): 3-10. https://doi.org/10.3892/mco.2015.666
Copy and paste a formatted citation
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Spandidos Publications style
Guo CX, Wang J, Huang LH, Li J and Chen X: Impact of single‑nucleotide polymorphisms on radiation pneumonitis in cancer patients (Review). Mol Clin Oncol 4: 3-10, 2016.
APA
Guo, C., Wang, J., Huang, L., Li, J., & Chen, X. (2016). Impact of single‑nucleotide polymorphisms on radiation pneumonitis in cancer patients (Review). Molecular and Clinical Oncology, 4, 3-10. https://doi.org/10.3892/mco.2015.666
MLA
Guo, C., Wang, J., Huang, L., Li, J., Chen, X."Impact of single‑nucleotide polymorphisms on radiation pneumonitis in cancer patients (Review)". Molecular and Clinical Oncology 4.1 (2016): 3-10.
Chicago
Guo, C., Wang, J., Huang, L., Li, J., Chen, X."Impact of single‑nucleotide polymorphisms on radiation pneumonitis in cancer patients (Review)". Molecular and Clinical Oncology 4, no. 1 (2016): 3-10. https://doi.org/10.3892/mco.2015.666
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