PIM1 kinase as a promise of targeted therapy in prostate cancer stem cells (Review)

  • Authors:
    • Yingqiu Xie
    • Samat Bayakhmetov
  • View Affiliations

  • Published online on: November 9, 2015     https://doi.org/10.3892/mco.2015.673
  • Pages: 13-17
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Since the last decade, the PIM family serine/threonine kinases have become a focus in cancer research. Numerous clinical data supports that overexpression of PIM1 is associated with tumor formation in various tissues. However, little is known regarding the function of PIM1 in cancer stem cells. In cancer cells, PIM1 has essential roles in the regulation of the cell cycle, cell proliferation, cell survival and multiple drug resistance. In stem cells, PIM1 kinase exhibits a significant function in stem cell proliferation, self‑renewal and expansion. Thus, PIM1 shows a great promise in cancer therapy by targeting stem cells. Furthermore, it is imperative to investigate Pim‑1 targeting in cancer stem cells by applicable inhibitors for improving future outcomes. The present review investigated the potential of PIM1 as a therapy target in prostate cancer stem cells.
View Figures
View References

Related Articles

Journal Cover

January-2016
Volume 4 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Xie Y and Xie Y: PIM1 kinase as a promise of targeted therapy in prostate cancer stem cells (Review). Mol Clin Oncol 4: 13-17, 2016
APA
Xie, Y., & Xie, Y. (2016). PIM1 kinase as a promise of targeted therapy in prostate cancer stem cells (Review). Molecular and Clinical Oncology, 4, 13-17. https://doi.org/10.3892/mco.2015.673
MLA
Xie, Y., Bayakhmetov, S."PIM1 kinase as a promise of targeted therapy in prostate cancer stem cells (Review)". Molecular and Clinical Oncology 4.1 (2016): 13-17.
Chicago
Xie, Y., Bayakhmetov, S."PIM1 kinase as a promise of targeted therapy in prostate cancer stem cells (Review)". Molecular and Clinical Oncology 4, no. 1 (2016): 13-17. https://doi.org/10.3892/mco.2015.673