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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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International Journal of Molecular Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Case Report Open Access

Mogamulizumab treatment of refractory peripheral T-cell lymphoma following autologous stem cell transplantation: A case report

  • Authors:
    • Yukie Fujita
    • Aya Nakaya
    • Shinya Fujita
    • Masaaki Hotta
    • Hideaki Yoshimura
    • Yoshiko Azuma
    • Takahisa Nakanishi
    • Atsushi Satake
    • Kazuyoshi Ishii
    • Tomoki Ito
    • Shosaku Nomura
  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Kansai Medical University, Hirakata, Osaka 573‑1010, Japan
    Copyright: © Fujita et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 151-153
    |
    Published online on: December 7, 2015
       https://doi.org/10.3892/mco.2015.695
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Abstract

Peripheral T-cell lymphoma (PTCL) represents a small heterogeneous group of non-Hodgkin lymphoma (NHL) that accounts for ~10% of NHLs in western countries and ~25% of NHLs in Japan. The disease remains extremely difficult to treat. Therefore, novel treatment modalities are required. Mogamulizumab is a humanized immunoglobulin G1 monoclonal antibody that targets CC chemokine receptor 4. To the best of our knowledge, the efficacy of mogamulizumab in patients who are refractory to conventional chemotherapy following autologous stem cell transplantation has not been investigated previously. The present study reports a patient with PTCL who relapsed following autologous stem cell transplantation and became resistant to salvage chemotherapy, in whom mogamulizumab showed evident efficacy without severe adverse event.
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1 

No authors: listed: T he World Health Organization classification of malignant lymphomas in Japan: Incidence of recently recognized entities. Histopathology. Pathol Int. 50:696–702. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Aoki R, Karube K, Sugita Y, Nomura Y, Shimizu K, Kimura Y, Hashikawa K, Suefuji N and Kikuchi M: Distribution of malignant lymphoma in Japan, Analysis of 2260 cases, 2001-2006. Pathol Int. 58:174–182. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Ogura M, Ishida T, Hatake K, Taniwaki M, Ando K, Tobinai K, Fujimoto K, Yamamoto K, Miyamoto T and Uike N: Multicenter phase II study of mogamulizumab (KW-0761), a defucosylated anti-cc chemokine receptor 4 antibody, in patients with relapsed peripheral T-cell lymphoma and cutaneous T-cell lymphoma. J Clin Oncol. 32:1157–1163. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Swerdlow SH, Campo E, Harris NL, et al: WHO Classification of Tumours of Haematolopoietic and Lymphoid Tissues (4th). Lyon: IARC. 2008.

5 

Imai T, Nagira M, Takagi S, Kakizaki M, Nishimura M, Wang J, Gray PW, Matsushima K and Yoshie O: Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Int Immunol. 11:81–88. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Niwa R, Shoji-Hosaka E, Sakurada M, Shinkawa T, Uchida K, Nakamura K, Matsushima K and Ueda R: Defucosylated chimeric anti-CC chemokine receptor 4 IgG1 with enhanced antibody-dependent cellular cytotoxicity shows potent therapeutic activity to T-cell leukemia and lymphoma. Cancer Res. 64:2127–2133. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Ishii T, Ishida T, Utsunomiya A, Inagaki A, Yano H, Komatsu H, Iida S, Imada K, Uchiyama T, Akinaga S, et al: Defucosylated humanized anti-CCR4 monoclonal antibody KW-0761 as a novel immunotherapeutic agent for adult T-cell leukemia/lymphoma. Clin Cancer Res. 16:1520–1531. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Ohshima K, Karube K, Kawano R, Tsuchiya T, Suefuji H, Yamaguchi T, Suzumiya J and Kikuchii M: Classification of distinct subtypes of peripheral T-cell lymphoma unspecified, identified by chemokine and chemokine receptor expression, Analysis of prognosis. Int J Oncol. 25:605–613. 2004.PubMed/NCBI

9 

Nakagawa M, Nakagawa-Oshiro A, Karnan S, Tagawa H, Utsunomiya A, Nakamura S, Takeuchi I, Ohshima K and Seto M: Array comparative genomic hybridization analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type adult T-cell leukemia/lymphoma. Clin Cancer Res. 15:30–38. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Ishida T and Ueda R: Immunopathogenesis of lymphoma: Focus on CCR4. Cancer Sci. 102:44–50. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Ishida T, Inagaki H, Utsunomiya A, Takatsuka Y, Komatsu H, Iida S, Takeuchi G, Eimoto T, Nakamura S and Ueda R: CXC chemokine receptor 3 and CC chemokine receptor 4 expression in T-cell and NK-cell lymphomas with special reference to clinicopathological significance for peripheral T-cell lymphoma, unspecified. Clin Cancer Res. 10:5494–5500. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Yamamoto K, Utsunomiya A, Tobinai K, Tsukasaki K, Uike N, Uozumi K, Yamaguchi K, Yamada Y, Hanada S, Tamura K, et al: Phase I study of KW-0761, a defucosylated humanized anti-CCR4 antibody, in relapsed patients with adult T-cell leukemia-lymphoma and peripheral T-cell lymphoma. J Clin Oncol. 28:1591–1598. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Duvic M, Pinter-Brown L, Foss FM, Sokol L, Jorgensen JL, et al: Phase 1/2 study of mogamulizumab, a defucosylated anti-CCR4 antibody, in previously treated patients with cutaneous T-cell lymphoma. Blood. 125:1883–1889. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fujita Y, Nakaya A, Fujita S, Hotta M, Yoshimura H, Azuma Y, Nakanishi T, Satake A, Ishii K, Ito T, Ito T, et al: Mogamulizumab treatment of refractory peripheral T-cell lymphoma following autologous stem cell transplantation: A case report. Mol Clin Oncol 4: 151-153, 2016.
APA
Fujita, Y., Nakaya, A., Fujita, S., Hotta, M., Yoshimura, H., Azuma, Y. ... Nomura, S. (2016). Mogamulizumab treatment of refractory peripheral T-cell lymphoma following autologous stem cell transplantation: A case report. Molecular and Clinical Oncology, 4, 151-153. https://doi.org/10.3892/mco.2015.695
MLA
Fujita, Y., Nakaya, A., Fujita, S., Hotta, M., Yoshimura, H., Azuma, Y., Nakanishi, T., Satake, A., Ishii, K., Ito, T., Nomura, S."Mogamulizumab treatment of refractory peripheral T-cell lymphoma following autologous stem cell transplantation: A case report". Molecular and Clinical Oncology 4.2 (2016): 151-153.
Chicago
Fujita, Y., Nakaya, A., Fujita, S., Hotta, M., Yoshimura, H., Azuma, Y., Nakanishi, T., Satake, A., Ishii, K., Ito, T., Nomura, S."Mogamulizumab treatment of refractory peripheral T-cell lymphoma following autologous stem cell transplantation: A case report". Molecular and Clinical Oncology 4, no. 2 (2016): 151-153. https://doi.org/10.3892/mco.2015.695
Copy and paste a formatted citation
x
Spandidos Publications style
Fujita Y, Nakaya A, Fujita S, Hotta M, Yoshimura H, Azuma Y, Nakanishi T, Satake A, Ishii K, Ito T, Ito T, et al: Mogamulizumab treatment of refractory peripheral T-cell lymphoma following autologous stem cell transplantation: A case report. Mol Clin Oncol 4: 151-153, 2016.
APA
Fujita, Y., Nakaya, A., Fujita, S., Hotta, M., Yoshimura, H., Azuma, Y. ... Nomura, S. (2016). Mogamulizumab treatment of refractory peripheral T-cell lymphoma following autologous stem cell transplantation: A case report. Molecular and Clinical Oncology, 4, 151-153. https://doi.org/10.3892/mco.2015.695
MLA
Fujita, Y., Nakaya, A., Fujita, S., Hotta, M., Yoshimura, H., Azuma, Y., Nakanishi, T., Satake, A., Ishii, K., Ito, T., Nomura, S."Mogamulizumab treatment of refractory peripheral T-cell lymphoma following autologous stem cell transplantation: A case report". Molecular and Clinical Oncology 4.2 (2016): 151-153.
Chicago
Fujita, Y., Nakaya, A., Fujita, S., Hotta, M., Yoshimura, H., Azuma, Y., Nakanishi, T., Satake, A., Ishii, K., Ito, T., Nomura, S."Mogamulizumab treatment of refractory peripheral T-cell lymphoma following autologous stem cell transplantation: A case report". Molecular and Clinical Oncology 4, no. 2 (2016): 151-153. https://doi.org/10.3892/mco.2015.695
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