Association of the p53 or GSTM1 polymorphism with the risk of nasopharyngeal carcinoma: A meta‑analysis

Wu,Muyun; Huang,Shujing; Liu,Dong; Peng,Miao; Yang,Fan; Wang,Xicheng

doi:10.3892/mco.2015.700

February-2016 Volume 4 Issue 2

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

February-2016 Volume 4 Issue 2

Full Size Image

Article

Association of the p53 or GSTM1 polymorphism with the risk of nasopharyngeal carcinoma: A meta‑analysis

Authors:
- Muyun Wu
- Shujing Huang
- Dong Liu
- Miao Peng
- Fan Yang
- Xicheng Wang
View Affiliations / Copyright

Affiliations: Department of Oncology, The Fifth People's Hospital of Wuhu, Wuhu, Anhui 241000, P.R. China, Department of Oncology, First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China, Department of Internal Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China
Pages: 221-228
|
Published online on: December 8, 2015

https://doi.org/10.3892/mco.2015.700
Expand metrics +

Abstract

p53 and glutathione S‑transferase M1 (GSTM1) are the most popular suppressor genes. Several previous studies demonstrated positive associations of these gene polymorphisms with numerous cancer types, including hepatocellular cancer, while the association between p53/GSTM1 polymorphisms and the nasopharyngeal carcinoma (NPC) risk was inconsistent and underpowered. However, no studies investigating the combinational effect of these two genes on NPC risk were performed. To confirm the effects of p53 and GSTM1 polymorphisms on the risk of NPC, a meta‑analysis of all the available previous studies associating p53 and GSTM1 with the risk of NPC was performed. A comprehensive search of PubMed, Web of Science and SD database until November 2014 was performed to identify the relevant studies. The data were extracted by two independent authors and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Meta‑regression and subgroup analyses were performed to identify the source of heterogeneity. Finally, five studies with 1,419 cases and 1,707 controls were included for the p53 polymorphism and three studies with 837 cases and 1,299 controls were included for the GSTM1 polymorphism. Regarding p53, a significantly increased NPC risk was observed in the overall population (C vs. G, OR, 1.245; 95% CI, 1.045‑1.483; P=0.014; additive models: CC vs. GG, OR, 1.579; 95% CI, 1.100‑2.265; P=0.013 and CG vs. GG, OR, 1.230; 95% CI, 1.039‑1.456; P=0.016; dominant model, OR, 1.321; 95% CI, 1.127‑1.549; P=0.001; recessive model, OR, 1.429; 95% CI, 1.017‑2.009; P=0.040). Concerning GSTM1, a significantly increased NPC risk was observed in the overall population (null versus non‑null, OR, 1.282; 95% CI, 1.075‑1.530; P=0.006). In the subgroup analyses stratified by the source of controls, a significant association of p53 with NPC risk was also demonstrated, while no association with GSTM1 was observed. Therefore, the p53 G72C polymorphism may have a susceptible role in the carcinogenesis of NPC, while genetic deletion of GSTM1 may contribute to increased susceptibility to NPC. Further large and well‑designed studies are required to confirm this association.

View Figures

View References

1	Lee AW, Ng WT, Chan YH, Sze H, Chan C and Lam TH: The battle against nasopharyngeal cancer. Radiother Oncol. 104:272–278. 2012. View Article : Google Scholar : PubMed/NCBI
2	Bei JX, Li Y, Jia WH, Feng BJ, Zhou G, Chen LZ, Feng QS, Low HQ, Zhang H, He F, et al: A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat Genet. 42:599–603. 2010. View Article : Google Scholar : PubMed/NCBI
3	Chang CM, Yu KJ, Mbulaiteye SM, Hildesheim A and Bhatia K: The extent of genetic diversity of Epstein-Barr virus and its geographic and disease patterns, A need for reappraisal. Virus Res. 143:209–221. 2009. View Article : Google Scholar : PubMed/NCBI
4	Cho WC: Nasopharyngeal carcinoma: M olecular biomarker discovery and progress. Mol Cancer. 6:12007. View Article : Google Scholar : PubMed/NCBI
5	Horikawa T, Yoshizaki T, Kondo S, Furukawa M, Kaizaki Y and Pagano JS: Epstein-Barr virus latent membrane protein 1 induces snail and epithelial-mesenchymal transition in metastatic nasopharyngeal carcinoma. Br J Cancer. 104:1160–1167. 2011. View Article : Google Scholar : PubMed/NCBI
6	Hildesheim A and Wang CP: Genetic predisposition factors and nasopharyngeal carcinoma risk: A review of epidemiological association studies 2000-2011: Rosetta Stone for NPC: Genetics, viral infection and other environmental factors. Semin Cancer Biol. 22:107–116. 2012. View Article : Google Scholar : PubMed/NCBI
7	Su CK and Wang CC: Prognostic value of Chinese race in nasopharyngeal cancer. Int J Radiat Oncol Biol Phys. 54:752–758. 2002. View Article : Google Scholar : PubMed/NCBI
8	Qin HD, Shugart YY, Bei JX, Pan QH, Chen L, Feng QS, Chen LZ, Huang W, Liu JJ, Jorgensen TJ, et al: Comprehensive pathway-based association study of DNA repair gene variants and the risk of nasopharyngeal carcinoma. Cancer Res. 71:3000–3008. 2011. View Article : Google Scholar : PubMed/NCBI
9	Levine AJ and Oren M: The first 30 years of p53: Growing ever more complex. Nat Rev Cancer. 9:749–758. 2009. View Article : Google Scholar : PubMed/NCBI
10	Goodsell DS: The molecular perspective: p53 tumor suppressor. Oncologist. 4:138–139. 1999.PubMed/NCBI
11	Hickman ES and Helin K: The p53 tumor suppressor protein. Biotechnol Genet Eng Rev. 17:179–211. 2000. View Article : Google Scholar : PubMed/NCBI
12	Jiang P, Liu J, Zeng X, Li W and Tang J: Association of TP53 codon 72 polymorphism with cervical cancer risk in Chinese women. Cancer Genet Cytogenet. 197:174–178. 2010. View Article : Google Scholar : PubMed/NCBI
13	Xiong X, Wang M, Wang L, Liu J, Zhao X, Tian Z and Wang J: Risk of MDM2 SNP309 alone or in combination with the p53 codon 72 polymorphism in acute myeloid leukemia. Leuk Res. 33:1454–1458. 2009. View Article : Google Scholar : PubMed/NCBI
14	Hayes JD and Pulford DJ: The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol. 30:445–600. 1995. View Article : Google Scholar : PubMed/NCBI
15	Parl FF: Glutathione S-reansferase genotypes and cancer risk. Cancer Lett. 221:123–129. 2005. View Article : Google Scholar : PubMed/NCBI
16	Scheneider J, Bernges U, Philipp M and Woitowitz HJ: GSTM1, GSTT1 and GSTP1 polymorphism and lung cancer risk in relation to tobacco smoking. Cancer Lett. 208:65–74. 2004. View Article : Google Scholar : PubMed/NCBI
17	Thakkinstian A, McEvoy M, Minelli C, Gibson P, Hancox B, Duffy D, Thompson J, Hall I, Kaufman J, Leung TF, et al: Systematic review and meta-analysis of the association between {beta}2-adrenoceptor polymorphisms and asthma: A HuGE review. Am J Epidemiol. 162:201–211. 2005. View Article : Google Scholar : PubMed/NCBI
18	Higgins JP and Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 21:1539–1558. 2002. View Article : Google Scholar : PubMed/NCBI
19	Higgins JP, Thompson SG, Deeks JJ and Altman DG: Measuring inconsistency in meta-analyses. BMJ. 327:557–560. 2003. View Article : Google Scholar : PubMed/NCBI
20	DerSimonian R and Laird N: Meta-analysis in clinical trials. Control Clin Trials. 7:177–188. 1986. View Article : Google Scholar : PubMed/NCBI
21	Mantel N and Haenszel W: Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 22:719–748. 1959.PubMed/NCBI
22	Egger M, Smith Davey G, Schneider M and Minder C: Bias in meta-analysis detected by a simple, graphical test. BMJ. 315:629–634. 1997. View Article : Google Scholar : PubMed/NCBI
23	Stuck AE, Rubenstein LZ and Wieland D: Bias in meta-analysis detected by a simple, graphical test. Histopathology. BMJ. 316:470–471. 1998. View Article : Google Scholar
24	Duval S and Tweedie R: Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 56:455–463. 2000. View Article : Google Scholar : PubMed/NCBI
25	Golovleva I, Birgander R, Själander A, Lundgren E and Beckman L: Interferon-alpha and p53 alleles involved in nasopharyngeal carcinoma. Carcinogenesis. 18:645–647. 1997. View Article : Google Scholar : PubMed/NCBI
26	Tsai MH, Lin CD, Hsieh YY, Chang FC, Tsai FJ, Chen WC and Tsai CH: Prognostic significance of the proline form of p53 codon 72 polymorphism in nasopharyngeal carcinoma. Laryngoscope. 112:116–119. 2002. View Article : Google Scholar : PubMed/NCBI
27	Xiao M, Zhang L, Zhu X, Huang J, Jiang H, Hu S and Liu Y: Genetic polymorphisms of MDM2 and TP53 genes are associated with risk of nasopharyngeal carcinoma in a Chinese population. BMC Cancer. 10:1472010. View Article : Google Scholar : PubMed/NCBI
28	Li L, Wu J, Sima X, Bai P, Deng W, Deng X, Zhang L and Gao L: Interactions of miR-34b/c and TP-53 polymorphisms on the risk of nasopharyngeal carcinoma. Tumor Biol. 34:1919–1923. 2013. View Article : Google Scholar
29	Zhang XA, Chen X, Zhai Y, Cui Y, Cao P, Zhang H, Wu Z, Li P, Yu L, Xia X, et al: Combined effects of genetic variants of the PTEN, AKT1, MDM2 and p53 genes on the risk of nasopharyngeal carcinoma. PLoS One. 9:e921352014. View Article : Google Scholar : PubMed/NCBI
30	Cheng YJ, Chien YC, Hildesheim A, Hsu MM, Chen IH, Chuang J, Chang J, Ma YD, Luo CT, Hsu WL, et al: No association between genetic polymorphisms of CYP1A1, GSTM1, GSTT1, GSTP1, NAT2 and nasopharyngeal carcinoma in Taiwan. Cancer Epidemiol Biomarkers Prev. 12:179–180. 2003.PubMed/NCBI
31	Guo XC, O'Brien SJ, Zeng Y, Nelson GW and Winkler CA: GSTM1 and GSTT1 gene deletions and the risk for nasopharyngeal carcinoma in Han Chinese. Cancer Epidemiol Biomarkers Prev. 17:1760–1763. 2008. View Article : Google Scholar : PubMed/NCBI
32	Jiang Y, Li N, Dong P, Zhang N, Sun Y, Han M, Wen J and Chen M: Polymorphisms in GSTM1, GSTT1 and GSTP1 and nasopharyngeal cancer in the east of China, A case-control study. Asian Pac J Cancer Prev. 12:3097–3100. 2011.PubMed/NCBI
33	Hu S, Zhou G, Zhang L, Jiang H and Xiao M: The effects of functional polymorphisms in the TGFβ1 gene on nasopharyngeal carcinoma susceptibility. Otolaryngol Head Neck Surg. 146:579–584. 2012. View Article : Google Scholar : PubMed/NCBI
34	Ben Chaaben A, Busson M, Douik H, Boukouaci W, Mamoghli T, Chaouch L, Harzallah L, Dorra S, Fortier C, Ghanem A, et al: Association of IL-12p40+1188A/C polymorphism with nasopharyngeal cancer risk and tumor extension. Tissue Antigens. 78:148–151. 2011. View Article : Google Scholar : PubMed/NCBI
35	Chang KW, Lin SC, Mangold KA, Jean MS, Yuan TC, Lin SN and Chang CS: Alterations of adenomatous polyposis Coli (APC) gene in oral squamous cell carcinoma. Int J Oral Maxillofac Surg. 29:223–226. 2000. View Article : Google Scholar : PubMed/NCBI
36	Rosenthal AN, Ryan A, Al-Jehani RM, Storey A, Harwood CA and Jacobs IJ: P53 codon 72 polymorphism and risk of cervical cancer in UK. Lancet. 352:871–872. 1998. View Article : Google Scholar : PubMed/NCBI
37	Wang NM, Tsai CH, Yeh KT, Chen SJ and Chang JG: P53 codon 72Arg polymorphism is not a risk factor for carcinogenesis in the Chinese. Int J Mol Med. 4:249–252. 1995.
38	Zhuo W, Wang Y, Zhuo X, Zhu Y, Wang W, Zhu B, Li D and Chen Z: CYP1A1 and GSTM1 polymorphisms and oral cancer risk, Association studies via evidence-based meta-analyses. Cancer Invest. 27:86–95. 2009. View Article : Google Scholar : PubMed/NCBI
39	Gao LB, Pan XM, Li LJ, Liang WB, Bai P, Rao L, Su XW, Wang T, Zhou B, Wei YG, et al: Null genotypes of GSTM1 and GSTT1 contribute to risk of cervical neoplasia: An evidence-based meta-analysis. PLoS One. 6:e201572011. View Article : Google Scholar : PubMed/NCBI
40	White DL, Li D, Nurgalieva Z and El-Serag HB: Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma A HuGE systematic review and meta-analysis. Am J Epidemiol. 167:377–389. 2008. View Article : Google Scholar : PubMed/NCBI
41	Zhou XL, Cai L, Xiang ZL, Zhou WL, Wang Y and Zhang XY: TP53 codon 72 polymorphism contributes to nasopharyngeal cancer susceptibility, A meta-analysis. Arch Med Res. 40:299–305. 2008. View Article : Google Scholar
42	Ren WH, Jiang DK, Pei Y, Wang SQ, Yang XM and Yu L: Meta-analysis of associations between the TP53 Arg72Pro polymorphism with risk of head and neck carcinomas based on case-control studies. Genet Mol Res. 13:103–114. 2014. View Article : Google Scholar : PubMed/NCBI
43	Cai K, Wang Y, Zhao X and Bao X: Association between the P53 codon 72 polymorphism and nasopharyngeal cancer risk. Tumor Biol. 35:1891–1897. 2014. View Article : Google Scholar
44	Zhou X, Cai L, Xiang Z, Li Q and Zhang X: GSTM1 and GSTT1 polymorphisms and nasopharyngeal cancer risk, An evidence-based meta-analysis. J Exp Clin Cancer Res. 28:462009. View Article : Google Scholar : PubMed/NCBI
45	Sun ZF, Zhang J, Xu HM, Wang GL and Dong P: Association between GSTM1 polymorphism and nasopharyngeal cancer susceptibility, A meta-analysis. Asian Pac J Cancer Prev. 13:5817–5821. 2012. View Article : Google Scholar : PubMed/NCBI
46	Wei Y, Zhou T, Lin H, Sun M, Wang D, Li H and Li B: Significant associations between GSTM1/GSTT1 polymorphisms and nasopharyngeal cancer risk. Tumor Biol. 34:887–894. 2013. View Article : Google Scholar
47	Murthy AK, Kumar V and Suresh KP: Meta-analysis of GSTM1 and GSTT1 polymorphisms and risk of nasopharyngeal cancer. Asian Pac J Cancer Prev. 14:1697–1701. 2013. View Article : Google Scholar : PubMed/NCBI