Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
February-2016 Volume 4 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2016 Volume 4 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Symptoms at diagnosis as independent prognostic factors in retroperitoneal liposarcoma

  • Authors:
    • Satoru Taguchi
    • Haruki Kume
    • Hiroshi Fukuhara
    • Teppei Morikawa
    • Shigenori Kakutani
    • Yuta Takeshima
    • Hideyo Miyazaki
    • Motofumi Suzuki
    • Tetsuya Fujimura
    • Tohru Nakagawa
    • Akira Ishikawa
    • Yasuhiko Igawa
    • Yukio Homma
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo 113‑8655, Japan, Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113‑8655, Japan
  • Pages: 255-260
    |
    Published online on: December 8, 2015
       https://doi.org/10.3892/mco.2015.701
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The prognostic factors of retroperitoneal liposarcoma have yet to be clearly determined due to its rarity, whereas the prognostic value of symptoms at diagnosis has never been evaluated to date. In this context, we reviewed 24 consecutive patients with primary retroperitoneal liposarcoma who underwent surgical resection with curative intent at our institution. The Kaplan‑Meier analysis and the log‑rank test were used to estimate progression‑free survival (PFS; primary endpoint) and sarcoma‑specific survival (SSS; secondary endpoint). The effect of various clinicopathological factors, including symptoms at diagnosis, on these two endpoints was assessed with a Cox proportional hazards model. During the study period, 11 patients (45.8%) developed recurrence after the initial surgery and 8 (33.3%) succumbed to retroperitoneal liposarcoma, with a median follow‑up of 64 months. A total of 16 patients (66.7%) had symptoms at diagnosis, while the remaining 8 (33.3%) were diagnosed incidentally. The symptoms were palpability of the tumor (n=8); abdominal pain̸fullness (n=3); flank pain̸fullness (n=2); lower extremity pain (n=1); testicular pain due to varicocele (n=1); and discomfort on urination (n=1). Patients with symptoms at diagnosis were significantly more likely to develop recurrence (log‑rank test, P=0.0196) and were also more likely to succumb to sarcoma (P=0.0778) compared with asymptomatic patients. On the multivariate analysis, symptoms at diagnosis and dedifferentiated components were independent predictors of poor PFS, while positive surgical margins were predictors of poor SSS. Given that symptoms at diagnosis are easily accessible for physicians, they may prove to be useful additional prognostic factors for primary retroperitoneal liposarcoma.
View Figures

Figure 1

Figure 2

View References

1 

Mettlin C, Priore R, Rao U, Gamble D, Lane W and Murphy P: Results of the national soft-tissue sarcoma registry. J Surg Oncol. 19:224–227. 1982. View Article : Google Scholar : PubMed/NCBI

2 

Singer S, Maki RG and O'Sullivan B: Soft tissue sarcoma. Cancer: Principles and Practice of Oncology Primer of the Molecular Biology of Cancer (9th). DeVita VT Jr, Lawrence TS and Rosenberg SA: (Philadelphia, PA). Lippincott Williams & Wilkins. 1533–1577. 2011.

3 

Fernández-Ruiz M, Rodríguez-Gil Y, Guerra-Vales JM, Manrique-Municio A, Moreno-González E and Colina-Ruizdelgado F: Primary retroperitoneal liposarcoma Clinical and histological analysis of ten cases. Gastroenterol Hepatol. 33:370–376. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Vijay A and Ram L: Retroperitoneal liposarcoma: A comprehensive review. Am J Clin Oncol. 38:213–219. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Singer S, Corson JM, Demetri GD, Healey EA, Marcus K and Eberlein TJ: Prognostic factors predictive of survival for truncal and retroperitoneal soft-tissue sarcoma. Ann Surg. 221:185–195. 1995. View Article : Google Scholar : PubMed/NCBI

6 

An JY, Heo JS, Noh JH, Sohn TS, Nam SJ, Choi SH, Joh JW and Kim SJ: Primary malignant retroperitoneal tumors, Analysis of a single institutional experience. Eur J Surg Oncol. 33:376–382. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Lewis JJ, Leung D, Woodruff JM and Brennan MF: Retroperitoneal soft-tissue sarcoma, Analysis of 500 patients treated and followed at a single institution. Ann Surg. 228:355–365. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Gronchi A, Miceli R, Shurell E, Eilber FC, Eilber FR, Anaya DA, Kattan MW, Honoré C, Lev DC, Colombo C, et al: Outcome prediction in primary resected retroperitoneal soft tissue sarcoma: Histology-specific overall survival and disease-free survival nomograms built on major sarcoma center data sets. J Clin Oncol. 31:1649–1655. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Nakagawa T, Hara T, Kawahara T, Ogata Y, Nakanishi H, Komiyama M, Arai E, Kanai Y and Fujimoto H: Prognostic risk stratification of patients with urothelial carcinoma of the bladder with recurrence after radical cystectomy. J Urol. 189:1275–1281. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Szendroi A, Tabák A, Riesz P, Szucs M, Nyírády P, Majoros A, Haas G and Romics I: Clinical symptoms related to renal cell carcinoma are independent prognostic factors for intraoperative complications and overall survival. Int Urol Nephrol. 41:835–842. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Reyes-Gibby CC, Anderson KO, Merriman KW, Todd KH, Shete SS and Hanna EY: Survival patterns in squamous cell carcinoma of the head and neck, Pain as an independent prognostic factor for survival. J Pain. 15:1015–1022. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Kim MJ, Choi SB, Han HJ, Park PJ, Kim WB, Song TJ, Suh SO and Choi SY: Clinicopathological analysis and survival outcome of duodenal adenocarcinoma. Kaohsiung J Med Sci. 30:254–259. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Singer S, Antonescu CR, Riedel E and Brennan MF: Histologic subtype and margin of resection predict pattern of recurrence and survival for retroperitoneal liposarcoma. Ann Surg. 238:358–370; discussion 370–371. 2003.

14 

Lahat G, Tuvin D, Wei C, Anaya DA, Bekele BN, Lazar AJ, Pisters PW, Lev D and Pollock RE: New perspectives for staging and prognosis in soft tissue sarcoma. Ann Surg Oncol. 15:2739–2748. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Edge S, Byrd DR, Compton CC, Fritz AG, Greene FL and Trotti A: American Joint Committee on Cancer (AJCC) Cancer Staging Manual (7th). New York, NY: Springer. 2010.

16 

Szkandera J, Absenger G, Liegl-Atzwanger B, Pichler M, Stotz M, Samonigg H, Glehr M, Zacherl M, Stojakovic T, Gerger A and Leithner A: Elevated preoperative neutrophil/lymphocyte ratio is associated with poor prognosis in soft-tissue sarcoma patients. Br J Cancer. 108:1677–1683. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Nakamura T, Matsumine A, Matsubara T, Asanuma K, Uchida A and Sudo A: The combined use of the neutrophil-lymphocyte ratio and C-reactive protein level as prognostic predictors in adult patients with soft tissue sarcoma. J Surg Oncol. 108:481–485. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Choi ES, Kim HS and Han I: Elevated preoperative systemic inflammatory markers predict poor outcome in localized soft tissue sarcoma. Ann Surg Oncol. 21:778–785. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Szkandera J, Gerger A, Liegl-Atzwanger B, Absenger G, Stotz M, Friesenbichler J, Trajanoski S, Stojakovic T, Eberhard K, Leithner A and Pichler M: The lymphocyte/monocyte ratio predicts poor clinical outcome and improves the predictive accuracy in patients with soft tissue sarcomas. Int J Cancer. 135:362–370. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Taguchi S, Kume H, Fukuhara H, Morikawa T, Kakutani S, Takeshima Y, Miyazaki H, Suzuki M, Fujimura T, Nakagawa T, Nakagawa T, et al: Symptoms at diagnosis as independent prognostic factors in retroperitoneal liposarcoma. Mol Clin Oncol 4: 255-260, 2016.
APA
Taguchi, S., Kume, H., Fukuhara, H., Morikawa, T., Kakutani, S., Takeshima, Y. ... Homma, Y. (2016). Symptoms at diagnosis as independent prognostic factors in retroperitoneal liposarcoma. Molecular and Clinical Oncology, 4, 255-260. https://doi.org/10.3892/mco.2015.701
MLA
Taguchi, S., Kume, H., Fukuhara, H., Morikawa, T., Kakutani, S., Takeshima, Y., Miyazaki, H., Suzuki, M., Fujimura, T., Nakagawa, T., Ishikawa, A., Igawa, Y., Homma, Y."Symptoms at diagnosis as independent prognostic factors in retroperitoneal liposarcoma". Molecular and Clinical Oncology 4.2 (2016): 255-260.
Chicago
Taguchi, S., Kume, H., Fukuhara, H., Morikawa, T., Kakutani, S., Takeshima, Y., Miyazaki, H., Suzuki, M., Fujimura, T., Nakagawa, T., Ishikawa, A., Igawa, Y., Homma, Y."Symptoms at diagnosis as independent prognostic factors in retroperitoneal liposarcoma". Molecular and Clinical Oncology 4, no. 2 (2016): 255-260. https://doi.org/10.3892/mco.2015.701
Copy and paste a formatted citation
x
Spandidos Publications style
Taguchi S, Kume H, Fukuhara H, Morikawa T, Kakutani S, Takeshima Y, Miyazaki H, Suzuki M, Fujimura T, Nakagawa T, Nakagawa T, et al: Symptoms at diagnosis as independent prognostic factors in retroperitoneal liposarcoma. Mol Clin Oncol 4: 255-260, 2016.
APA
Taguchi, S., Kume, H., Fukuhara, H., Morikawa, T., Kakutani, S., Takeshima, Y. ... Homma, Y. (2016). Symptoms at diagnosis as independent prognostic factors in retroperitoneal liposarcoma. Molecular and Clinical Oncology, 4, 255-260. https://doi.org/10.3892/mco.2015.701
MLA
Taguchi, S., Kume, H., Fukuhara, H., Morikawa, T., Kakutani, S., Takeshima, Y., Miyazaki, H., Suzuki, M., Fujimura, T., Nakagawa, T., Ishikawa, A., Igawa, Y., Homma, Y."Symptoms at diagnosis as independent prognostic factors in retroperitoneal liposarcoma". Molecular and Clinical Oncology 4.2 (2016): 255-260.
Chicago
Taguchi, S., Kume, H., Fukuhara, H., Morikawa, T., Kakutani, S., Takeshima, Y., Miyazaki, H., Suzuki, M., Fujimura, T., Nakagawa, T., Ishikawa, A., Igawa, Y., Homma, Y."Symptoms at diagnosis as independent prognostic factors in retroperitoneal liposarcoma". Molecular and Clinical Oncology 4, no. 2 (2016): 255-260. https://doi.org/10.3892/mco.2015.701
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team