Development of combined thymic carcinoma and thymoma in an extrathymic lesion during long follow‑up for recurrent thymoma

Ohue,Yasuhiro; Matsuoka,Shunichiro; Kumeda,Hirotaka; Agatsuma,Hiroyuki; Hyougotani,Akira; Toishi,Masayuki; Shiina,Takayuki; Yoshida,Kazuo; Shingu,Kunihiko; Fukushima,Toshirou; Koizumi,Tomonobu

doi:10.3892/mco.2015.708

February-2016 Volume 4 Issue 2

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February-2016 Volume 4 Issue 2

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Article

Development of combined thymic carcinoma and thymoma in an extrathymic lesion during long follow‑up for recurrent thymoma

Authors:
- Yasuhiro Ohue
- Shunichiro Matsuoka
- Hirotaka Kumeda
- Hiroyuki Agatsuma
- Akira Hyougotani
- Masayuki Toishi
- Takayuki Shiina
- Kazuo Yoshida
- Kunihiko Shingu
- Toshirou Fukushima
- Tomonobu Koizumi
View Affiliations / Copyright

Affiliations: Division of Thoracic Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Nagano 390‑8621, Japan, Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Nagano 390‑8621, Japan, Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Nagano 390‑8621, Japan
Pages: 139-142
|
Published online on: December 11, 2015

https://doi.org/10.3892/mco.2015.708
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Abstract

The present study reported a rare case of combined thymic squamous cell carcinoma and thymoma exhibiting a mass on the left chest wall. The patient underwent thoracotomy for invasive thymoma 15 years previously, however, suffered a relapse in the left intrathoracic space. Radiotherapy, chemotherapy and partial resection, as secondary surgery for the intrathoracic mass, were performed. The histological findings in the resected specimens revealed type B3 thymoma. As the patient developed a left chest wall mass and pain in 2013, the mass was resected. The histological findings indicated two separate components composed of type B3 thymoma and squamous cell carcinoma. Immunohistological findings revealed that the thymoma cells were positive for CD5, while the thymic carcinoma cells were negative for CD5. Several reports have demonstrated the coexistence of thymic carcinoma and thymoma in the primary thymus, however, the development of a combined tumor in an extrathymic lesion is extremely rare. The present case had a long follow‑up for recurrent thymoma. The present case indicated that the development and/or coexistence of malignant components in the thymoma must be taken into consideration for the treatment and/or management of patients with thymoma and that a pre‑existence of CD5 expression in thymoma and the lost change may be associated with the process of malignant transformation.

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1	Mikhail M, Mekhail Y and Mekhail T: Thymic neoplasms, A clinical update. Curr Oncol Rep. 14:350–358. 2012. View Article : Google Scholar : PubMed/NCBI
2	Hejna M, Haberl I and Raderer M: Nonsurgical management of malignant thymoma. Cancer. 85:1871–1884. 1999. View Article : Google Scholar : PubMed/NCBI
3	Kondo K and Monden Y: Therapy for thymic epithelial tumors: A clinical study of 1,320 patients from Japan. Ann Thorac Surg. 76:878–884. 2003. View Article : Google Scholar : PubMed/NCBI
4	Suster S and Rosai J: Thymic carcinoma. Histopathology. Cancer. 67:1025–1032. 1991. View Article : Google Scholar : PubMed/NCBI
5	Muller-Hermelink HK, Strobel P, Zettl A and Marx A: Combined thymic epithelial tumors. WHO classification of tumors of the lung, pleura, thymus and heart. Travis WD, Brambilla E, Muller-Hermelink HK and Harris CC: (Lyon). IARC Press. 196–197. 2004.
6	Suster S and Moran CA: Primary thymic epithelial neoplasms showing combined features of thymoma and thymic carcinoma. Histopathology. Am J Surg Pathol. 20:1469–1480. 1996. View Article : Google Scholar : PubMed/NCBI
7	Morinaga S, Sato Y, Shimosato Y, Sinkai T and Tsuchiya R: Multiple thymic squamous cell carcinomas associated with mixed type thymoma. Am J Surg Pathol. 11:982–988. 1987. View Article : Google Scholar : PubMed/NCBI
8	Kuo TT and Chan JK: Thymic carcinoma arising in thymoma is associated with alterations in immunohistochemical profile. Am J Surg Pathol. 22:1474–1481. 1998. View Article : Google Scholar : PubMed/NCBI
9	Wagner KB, Khan A, Mir R and Herman PG: Thymic carcinoma arising from long standing thymoma and presenting with pituitary metastases. Comput Med lmaging Graph. 15:411–414. 1991. View Article : Google Scholar
10	Vilela Suarez D, Salas Valien JS, Moran Gonzalez MA, Lzquierdo Garcia F and Riera Velasco JR: Thymic carcinosarcoma associated with a spindle cell thymoma: An immunohistochemical study. Histopathology. 21:263–268. 1992. View Article : Google Scholar : PubMed/NCBI
11	Hartman CA, Roth C, Minck C and Niedobitek G: Thymic carcinoma. Histopathology. J Cancer Res Clin Oncol. 116:69–82. 1990. View Article : Google Scholar : PubMed/NCBI
12	Shimosato Y, Kameya T, Nagaki K and Suemasu K: Squamous cell carcinoma of the thymus, An analysis of eight cases. Am J Surg Pathol. 1:109–121. 1977. View Article : Google Scholar : PubMed/NCBI
13	Wu SG, Li Y, Li B, Tian XY and Li Z: Unusual combined thymic mucoepidermoid carcinoma and thymoma, A case report and review of literature. Diagn Pathol. 9:82014. View Article : Google Scholar : PubMed/NCBI
14	Kuo T, Chang JP, Lin FJ, Wu WC and Chang CH: Thymic carcinomas, Histopathological varieties and immunohistochemical study. Am J Surg Pathol. 14:24–34. 1990. View Article : Google Scholar : PubMed/NCBI
15	Masaoka A, Monden Y, Nakahara K and Tanioka T: Follow-up study of thymomas with special reference to their clinical stages. Cancer. 48:2485–2492. 1981. View Article : Google Scholar : PubMed/NCBI
16	Travis WD, Brambilla E, Muller-Hermelink HK and Harris CC: Pathology and genetics of tumours of the lung, pleura, thymus and heart. WHO Classification of Tumors of the Lung, Pleura, Thymus and Heart (Lyon). IARC press. 2004.
17	Filosso PL, Galassi C, Ruffini E, Margaritora S, Bertolaccini L, Casadio C, Anile M and Venuta F: Thymoma and the increased risk of developing extrathymic malignancies, A multicentre study. Eur J Cardiothorac Surg. 44:219–224. 2013. View Article : Google Scholar : PubMed/NCBI
18	Gadalla SM, Rajan A, Pfeiffer R, Kristinsson SY, Björkholm M, Landgren O and Giaccone G: A population-based assessment of mortality and morbidity patterns among patients with thymoma. Int J Cancer. 128:2688–2694. 2011. View Article : Google Scholar : PubMed/NCBI
19	Dorfman DM, Shahsafaei A and Chan JK: Thymic carcinomas, but not thymomas and carcinomas of other sites, show CD5 immunoreactivity. Am J Surg Pathol. 21:936–940. 1997. View Article : Google Scholar : PubMed/NCBI
20	Hishima T, Fukayama M, Fujisawa M, Hayashi Y, Arai K, Funata N and Koike M: CD5 expression in thymic carcinoma. Am J Pathol. 145:268–275. 1994.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Development of combined thymic carcinoma and thymoma in an extrathymic lesion during long follow‑up for recurrent thymoma

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