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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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Case Report

Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report

  • Authors:
    • Seyed Mehdi Hashemi
    • Seyed Amirhossein Fazeli
    • Abdolbaset Vahedi
    • Reza Golabchifard
  • View Affiliations / Copyright

    Affiliations: Division of Hematology and Medical Oncology, Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran, Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran , Students' Scientific Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
  • Pages: 436-440
    |
    Published online on: December 18, 2015
       https://doi.org/10.3892/mco.2015.715
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Abstract

Sweet's syndrome is a neutrophilic dermatosis characterised by sudden onset of fever, neutrophilia, erythematous skin rashes and neutrophilic infiltration of the dermis. Subcutaneous Sweet's syndrome, or Sweet's panniculitis, is an uncommon variant of the classic syndrome, with hypodermal neutrophilic infiltration. The association of Sweet's syndrome with various malignancies has been reported. The most common underlying hematological malignancies are of myeloid origin; however, there have been several reports of the classic Sweet's syndrome in patients with a lymphoproliferative disorder, although the association of subcutaneous Sweet's syndrome with lymphoproliferative disorders has not been well‑documented thus far. Herein, we present the case of a 48‑year‑old man with a 2‑year history of chronic lymphocytic leukemia who developed fever and skin rashes, without any evidence of a relapse. The clinical and pathological investigation resulted in the diagnosis of subcutaneous Sweet's syndrome. The patient exhibited no significant response to conventional therapeutic measures; however, following two subsequent doses of rituximab, his general condition and skin rash improved. The follow‑up skin biopsy demonstrated dermal neutrophilic infiltrations in conjunction with prior mixed lobular and septal panniculitis, suggesting evolution of subcutaneous Sweet's syndrome to its classic form. To the best of our knowledge, this is one of the first reports of rituximab as a novel biological treatment for Sweet's syndrome. However, further randomized trials are required to evaluate the efficacy and safety of such biological therapies for Sweet's syndrome.
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Copy and paste a formatted citation
Spandidos Publications style
Hashemi SM, Fazeli SA, Vahedi A and Golabchifard R: Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report. Mol Clin Oncol 4: 436-440, 2016.
APA
Hashemi, S.M., Fazeli, S.A., Vahedi, A., & Golabchifard, R. (2016). Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report. Molecular and Clinical Oncology, 4, 436-440. https://doi.org/10.3892/mco.2015.715
MLA
Hashemi, S. M., Fazeli, S. A., Vahedi, A., Golabchifard, R."Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report". Molecular and Clinical Oncology 4.3 (2016): 436-440.
Chicago
Hashemi, S. M., Fazeli, S. A., Vahedi, A., Golabchifard, R."Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report". Molecular and Clinical Oncology 4, no. 3 (2016): 436-440. https://doi.org/10.3892/mco.2015.715
Copy and paste a formatted citation
x
Spandidos Publications style
Hashemi SM, Fazeli SA, Vahedi A and Golabchifard R: Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report. Mol Clin Oncol 4: 436-440, 2016.
APA
Hashemi, S.M., Fazeli, S.A., Vahedi, A., & Golabchifard, R. (2016). Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report. Molecular and Clinical Oncology, 4, 436-440. https://doi.org/10.3892/mco.2015.715
MLA
Hashemi, S. M., Fazeli, S. A., Vahedi, A., Golabchifard, R."Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report". Molecular and Clinical Oncology 4.3 (2016): 436-440.
Chicago
Hashemi, S. M., Fazeli, S. A., Vahedi, A., Golabchifard, R."Rituximab for refractory subcutaneous Sweet's syndrome in chronic lymphocytic leukemia: A case report". Molecular and Clinical Oncology 4, no. 3 (2016): 436-440. https://doi.org/10.3892/mco.2015.715
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