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Article

A phase II, randomized study of aprepitant in the prevention of chemotherapy‑induced nausea and vomiting associated with moderately emetogenic chemotherapies in colorectal cancer patients

  • Authors:
    • Kuniaki Aridome
    • Shin‑Ichirou Mori
    • Kenji Baba
    • Masayuki Yanagi
    • Masahiro Hamanoue
    • Futoshi Miyazono
    • Kouki Tokuda
    • Hiroshi Imamura
    • Yoshito Ogura
    • Kouichi Kaneko
    • Fumio Kijima
    • Kousei Maemura
    • Sumiya Ishigami
    • Shoji Natsugoe
  • View Affiliations / Copyright

    Affiliations: Department of Digestive Surgery, Breast and Thyroid Surgery, Graduate School of Medicine, Kagoshima University, Sakuragaoka, Kagoshima 890‑8520, Japan, Department of Surgery, Imakiire General Hospital, Kagoshima 892‑8502, Japan, Department of Surgery, Kagoshima Prefectural Satsunan Hospital, Minamisatsuma, Kagoshima 897-1123, Japan, Department of Digestive Surgery, Kobayashi City Hospital, Kobayashi, Miyazaki 886‑0004, Japan, Department of Surgery, Izumi Regional Medical Center, Akune, Kagoshima 899-1611, Japan, Department of Surgery, Kagoshima Kouseiren Hospital, Kagoshima 890‑0061, Japan, Department of Surgery, Kaneko Hospital, Ichikikushikino, Kagoshima 896‑0055, Japan, Department of Surgery, Saiseikai Sendai Hospital, Satsumasendai, Kagoshima 895‑0074, Japan
  • Pages: 393-398
    |
    Published online on: December 31, 2015
       https://doi.org/10.3892/mco.2015.724
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Abstract

The present study aimed to study the efficacy of aprepitant in the prevention of chemotherapy‑induced nausea and vomiting (CINV) in patients receiving moderately emetogenic chemotherapy (MEC) for colorectal cancer (CRC), and comprised a multicenter, phase II, open‑label, randomized, parallel comparative study conducted as part of the Kagoshima aprepitant study for colon cancer in Japan. Patients with advanced or recurrent CRC were treated with standard MEC regimens (FOLFOX, XELOX or FOLFIRI) and received either standard chemotherapy [5‑hydroxytryptamine-3 receptor antagonist (5‑HT3 RA) + dexamethasone] or aprepitant regimen chemotherapy (5‑HT3 RA + reduced‑dose dexamethasone + aprepitant). The primary endpoint of the present study was the proportion of patients who achieved a complete response (CR) during the overall, acute, and delayed phases of the first planned chemotherapy cycle. Secondary endpoints were complete protection, the proportions of patients without emetic episodes or nausea, patients with no more than moderate nausea during the overall, acute and delayed phases, and the time to treatment failure. The CR rates in the overall, acute and delayed phases were similar in the aprepitant and the standard‑regimen groups. Additionally, there were no significant differences in secondary endpoints between the two groups. In summary, aprepitant in combination with 5‑HT3 RA and reduced‑dose corticosteroids was well tolerated and effective in preventing CINV associated with moderately emetogenic antitumor agents in Japanese patients with CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Aridome K, Mori SI, Baba K, Yanagi M, Hamanoue M, Miyazono F, Tokuda K, Imamura H, Ogura Y, Kaneko K, Kaneko K, et al: A phase II, randomized study of aprepitant in the prevention of chemotherapy‑induced nausea and vomiting associated with moderately emetogenic chemotherapies in colorectal cancer patients. Mol Clin Oncol 4: 393-398, 2016.
APA
Aridome, K., Mori, S., Baba, K., Yanagi, M., Hamanoue, M., Miyazono, F. ... Natsugoe, S. (2016). A phase II, randomized study of aprepitant in the prevention of chemotherapy‑induced nausea and vomiting associated with moderately emetogenic chemotherapies in colorectal cancer patients. Molecular and Clinical Oncology, 4, 393-398. https://doi.org/10.3892/mco.2015.724
MLA
Aridome, K., Mori, S., Baba, K., Yanagi, M., Hamanoue, M., Miyazono, F., Tokuda, K., Imamura, H., Ogura, Y., Kaneko, K., Kijima, F., Maemura, K., Ishigami, S., Natsugoe, S."A phase II, randomized study of aprepitant in the prevention of chemotherapy‑induced nausea and vomiting associated with moderately emetogenic chemotherapies in colorectal cancer patients". Molecular and Clinical Oncology 4.3 (2016): 393-398.
Chicago
Aridome, K., Mori, S., Baba, K., Yanagi, M., Hamanoue, M., Miyazono, F., Tokuda, K., Imamura, H., Ogura, Y., Kaneko, K., Kijima, F., Maemura, K., Ishigami, S., Natsugoe, S."A phase II, randomized study of aprepitant in the prevention of chemotherapy‑induced nausea and vomiting associated with moderately emetogenic chemotherapies in colorectal cancer patients". Molecular and Clinical Oncology 4, no. 3 (2016): 393-398. https://doi.org/10.3892/mco.2015.724
Copy and paste a formatted citation
x
Spandidos Publications style
Aridome K, Mori SI, Baba K, Yanagi M, Hamanoue M, Miyazono F, Tokuda K, Imamura H, Ogura Y, Kaneko K, Kaneko K, et al: A phase II, randomized study of aprepitant in the prevention of chemotherapy‑induced nausea and vomiting associated with moderately emetogenic chemotherapies in colorectal cancer patients. Mol Clin Oncol 4: 393-398, 2016.
APA
Aridome, K., Mori, S., Baba, K., Yanagi, M., Hamanoue, M., Miyazono, F. ... Natsugoe, S. (2016). A phase II, randomized study of aprepitant in the prevention of chemotherapy‑induced nausea and vomiting associated with moderately emetogenic chemotherapies in colorectal cancer patients. Molecular and Clinical Oncology, 4, 393-398. https://doi.org/10.3892/mco.2015.724
MLA
Aridome, K., Mori, S., Baba, K., Yanagi, M., Hamanoue, M., Miyazono, F., Tokuda, K., Imamura, H., Ogura, Y., Kaneko, K., Kijima, F., Maemura, K., Ishigami, S., Natsugoe, S."A phase II, randomized study of aprepitant in the prevention of chemotherapy‑induced nausea and vomiting associated with moderately emetogenic chemotherapies in colorectal cancer patients". Molecular and Clinical Oncology 4.3 (2016): 393-398.
Chicago
Aridome, K., Mori, S., Baba, K., Yanagi, M., Hamanoue, M., Miyazono, F., Tokuda, K., Imamura, H., Ogura, Y., Kaneko, K., Kijima, F., Maemura, K., Ishigami, S., Natsugoe, S."A phase II, randomized study of aprepitant in the prevention of chemotherapy‑induced nausea and vomiting associated with moderately emetogenic chemotherapies in colorectal cancer patients". Molecular and Clinical Oncology 4, no. 3 (2016): 393-398. https://doi.org/10.3892/mco.2015.724
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