Dysgerminoma developing from an ectopic ovary in a patient with WAGR syndrome: A case report

Miura,Rie; Yokoyama,Yoshihito; Shigeto,Tatsuhiko; Futagami,Masayuki; Mizunuma,Hideki; Kurose,Akira; Tsuruga,Kazushi; Sasaki,Shinya; Terui,Kiminori; Ito,Etsuro

doi:10.3892/mco.2016.1004

November-2016 Volume 5 Issue 5

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November-2016 Volume 5 Issue 5

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Case Report Open Access

Dysgerminoma developing from an ectopic ovary in a patient with WAGR syndrome: A case report

Authors:
- Rie Miura
- Yoshihito Yokoyama
- Tatsuhiko Shigeto
- Masayuki Futagami
- Hideki Mizunuma
- Akira Kurose
- Kazushi Tsuruga
- Shinya Sasaki
- Kiminori Terui
- Etsuro Ito
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan, Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan, Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036‑8562, Japan

Copyright: © Miura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 503-506
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Published online on: August 25, 2016

https://doi.org/10.3892/mco.2016.1004
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Abstract

WAGR syndrome is caused by an 11p13 deletion and includes Wilms' tumor, aniridia, genitourinary anomalies and mental retardation. We encountered a case of a dysgerminoma originating in an ectopic ovary in a woman with WAGR syndrome. Our patient was a 24‑year‑old nulliparous woman who was diagnosed with WAGR syndrome. The patient had undergone left nephrectomy for a Wilms' tumor and postoperative chemotherapy at the age of 7 months. She also had a history of glaucoma surgery in both eyes, and was followed up at the Department of Pediatrics for diabetes mellitus, hypertension, liver dysfunction and hyperuricemia. The patient was investigated for oliguria and had elevated levels of blood urea nitrogen (45 mg/dl) and creatinine (5.4 mg/dl); she was admitted to the hospital with acute renal failure and a computed tomography scan revealed a pelvic tumor with a long axis of 10 cm that was obstructing the right ureter. Following insertion of a ureteral stent, the tumor was removed. The tumor had developed in the retroperitoneal space independent of the ovaries. The right adnexa were normal. The tumor was histopathologically diagnosed as dysgerminoma. Follicles were found in part of the tumor; it was thus hypothesized that the tumor developed from an ectopic ovary. The patient was administered etoposide after surgery, and has been recurrence‑free for 4 years since treatment.

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1	Riccardi VM, Sujansky E, Smith AC and Francke U: Chromosomal imbalance in the Aniridia-Wilms' tumor association: 11p interstitial deletion. Pediatrics. 61:604–610. 1978.PubMed/NCBI
2	Yi T, Weng J, Siwko S, Luo J, Li D and Liu M: LGR4/GPR48 inactivation leads to aniridia-genitourinary anomalies-mental retardation syndrome defects. J Biol Chem. 289:8767–8780. 2014. View Article : Google Scholar : PubMed/NCBI
3	Watkins BP and Kothari SN: True ectopic ovary: A case and review. Arch Gynecol Obstet. 269:145–146. 2004. View Article : Google Scholar : PubMed/NCBI
4	Heller DS, Harpaz N and Breakstone B: Neoplasm arising in ectopic ovaries: A case of brenner tumor in an accessory ovary. Int J of Gynecol Pathol. 9:185–189. 1990. View Article : Google Scholar
5	Kini H, Baliga PB and Pai KG: Supernumerary ovary associated with Wilms' tumor. Pediatr Surg Int. 13:67–68. 1998. View Article : Google Scholar : PubMed/NCBI
6	Bae HS, Ryu MJ, Kim IS, Kim SH and Song JY: Cancer of the supernumerary ovary in Mayer-Rokitansky-Küster-Hauser Syndrome: A case report. Oncol Lett. 5:598–600. 2013.PubMed/NCBI
7	Wharton LR: Two cases of supernumerary ovary and one of accessory ovary with an analysis of previously reported cases. Am J Obstet Gynacol. 78:1101–1109. 1959.
8	El-Gohary Y, Pagkratis S, Lee T and Scriven RJ: Supernumerary ovary presenting as a paraduodenal duplication cyst. J Pediatr Surg Case Rep. 3:316–319. 2015. View Article : Google Scholar
9	Lachman MF and Berman MM: The ectopic ovary. A case report and review of the literature. Arch Pathol Lab Med. 115:233–235. 1991.PubMed/NCBI
10	Uyar I, Gulhan I, Sipahi M, Hanhan HM and Ozeren M: Ectopic ovary confirmed by ovarian stimulation in a case of unicornuate uterus. Fertil Steril. 96:e122–e124. 2011. View Article : Google Scholar : PubMed/NCBI
11	Ombelet W, Verswijvel G and de Jonge E: Ectopic ovary and unicornuate uterus. N Engl J Med. 348:667–668. 2003. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Dysgerminoma developing from an ectopic ovary in a patient with WAGR syndrome: A case report

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