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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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November-2016 Volume 5 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Case Report

High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review

  • Authors:
    • Eiko Yamamoto
    • Kaoru Niimi
    • Kayo Fujikake
    • Tetsuya Nishida
    • Makoto Murata
    • Ayako Mitsuma
    • Yuichi Ando
    • Fumitaka Kikkawa
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan, Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan, Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Aichi 466‑8550, Japan
  • Pages: 660-664
    |
    Published online on: September 8, 2016
       https://doi.org/10.3892/mco.2016.1011
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Abstract

Choriocarcinoma is a malignant gestational trophoblastic neoplasia (GTN) and one of the curable types of gynecological cancer. However, 10% of choriocarcinoma patients have a poor prognosis, particularly when they have metastasis, apart from pulmonary metastasis, or do not go into remission by the second chemotherapeutic regimen. We herein present the case of a 36‑year‑old patient who had choriocarcinoma with metastases to the lungs, liver and kidneys. The 5th and 6th regimens with cisplatin for choriocarcinoma failed and the patient developed brain metastases. She was then treated with four cycles of high‑dose ifosfamide, carboplatin and etoposide (ICE) with blood progenitor cell support after confirming the effectiveness of ICE at normal doses. The serum human chorionic gonadotropin (hCG) level was 140,009 mIU/ml at the start of high‑dose ICE and the patient tolerated this regimen well. However, the beneficial effect was decreasing with each successive course of treatment, with the lowest level of hCG at 103 mIU/ml after the fourth course. The patient did not achieve complete remission and succumbed to the disease 4 months after the last chemotherapy. The findings of the present case and a review of the related literature suggest that high‑dose ICE with stem cell rescue may be considered as a viable treatment option for a multi‑drug resistant choriocarcinoma or GTN.
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1 

Ngan HY, Bender H, Benedet JL, Jones H, Montruccoli GC and Pecorelli S: FIGO Committee on Gynecologic Oncology: Gestational trophoblastic neoplasia, FIGO 2000 staging and classification. Int J Gynaecol Obstet. 83(Suppl 1): S175–S177. 2003. View Article : Google Scholar

2 

Matsui H, Suzuka K, Iitsuka Y, Seki K and Sekiya S: Combination chemotherapy with methotrexate, etoposide, and actinomycin D for high-risk gestational trophoblastic tumors. Gynecol Oncol. 78:28–31. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Bower M, Newlands ES, Holden L, Short D, Brock C, Rustin GJ, Begent RH and Bagshawe KD: EMA/CO for high-risk gestational trophoblastic tumors: Results from a cohort of 272 patients. J Clin Oncol. 15:2636–2643. 1997.PubMed/NCBI

4 

Newlands ES, Mulholland PJ, Holden L, Seckl MJ and Rustin GJ: Etoposide and cisplatin/etoposide, methotrexate, and actinomycin D (EMA) chemotherapy for patients with high-risk gestational trophoblastic tumors refractory to EMA/cyclophosphamide and vincristine chemotherapy and patients presenting with metastatic placental site trophoblastic tumors. J Clin Oncol. 18:854–859. 2000.PubMed/NCBI

5 

Matsui H, Suzuka K, Iitsuka Y, Yamazawa K, Tanaka N, Mitsuhashi A, Seki K and Sekiya S: Salvage combination chemotherapy with 5-fluorouracil and actinomycin D for patients with refractory, high-risk gestational trophoblastic tumors. Cancer. 95:1051–1054. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Wang J, Short D, Sebire NJ, Lindsay I, Newlands ES, Schmid P, Savage PM and Seckl MJ: Salvage chemotherapy of relapsed or high-risk gestational trophoblastic neoplasia (GTN) with paclitaxel/cisplatin alternating with paclitaxel/etoposide (TP/TE). Ann Oncol. 19:1578–1583. 2008. View Article : Google Scholar : PubMed/NCBI

7 

van Besien K, Verschraegen C, Mehra R, Giralt S, Kudelka AP, Edwards CL, Piamsonboom S, Termrungruanglert W, Champlin R and Kavanagh JJ: Complete remission of refractory gestational trophoblastic disease with brain metastases treated with multicycle ifosfamide, carboplatin, and etoposide (ICE) and stem cell rescue. Gynecol Oncol. 65:366–369. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Lotz JP, André T, Donsimoni R, Firmin C, Bouleuc C, Bonnak H, Merad Z, Esteso A, Gerota J and Izrael V: High dose chemotherapy with ifosfamide, carboplatin, and etoposide combined with autologous bone marrow transplantation for the treatment of poor-prognosis germ cell tumors and metastatic trophoblastic disease in adults. Cancer. 75:874–885. 1995. View Article : Google Scholar : PubMed/NCBI

9 

Fields KK, Zorsky PE, Hiemenz JW, Kronish LE and Elfenbein GJ: Ifosfamide, carboplatin, and etoposide: A new regimen with a broad spectrum of activity. J Clin Oncol. 12:544–552. 1994.PubMed/NCBI

10 

Collins RH Jr, White CS, Stringer CA and Fay JW: Successful treatment of refractory gestational trophoblastic neoplasm with high-dose etoposide and cyclophosphamide. Gynecol Oncol. 43:317–319. 1991. View Article : Google Scholar : PubMed/NCBI

11 

Lotz JP, Machover D, Malassagne B, Hingh B, Donsimoni R, Gumus Y, Gerota J, Lam Y, Tulliez M, Marsiglia H, et al: Phase I–II study of two consecutive courses of high-dose epipodophyllotoxin, ifosfamide, and carboplatin with autologous bone marrow transplantation for treatment of adult patients with solid tumors. J Clin Oncol. 9:1860–1870. 1991.PubMed/NCBI

12 

Giacalone PL, Benos P, Donnadio D and Laffargue F: High-dose chemotherapy with autologous bone marrow transplantation for refractory metastatic gestational trophoblastic disease. Gynecol Oncol. 58:383–385. 1995. View Article : Google Scholar : PubMed/NCBI

13 

Aoki Y, Kodama S, Kurata H, Kase H and Tanaka K: Failure of high-dose chemotherapy with peripheral blood stem cell support for refractory placental site trophoblastic tumor. Gynecol Obstet Invest. 47:214–216. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Rinne K, Shahabi S and Cole L: Following metastatic placental site trophoblastic tumor with urine beta-core fragment. Gynecol Oncol. 74:302–303. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Knox S, Brooks SE, Wong-You-Cheong J, Ioffe O, Meisenberg B and Goldstein DP: Choriocarcinoma and epithelial trophoblastic tumor: Successful treatment of relapse with hysterectomy and high-dose chemotherapy with peripheral stem cell support: A case report. Gynecol Oncol. 85:204–208. 2002. View Article : Google Scholar : PubMed/NCBI

16 

Markman M: Experience with platinum-based and high-dose chemotherapy in patients with gestational trophoblastic disease: Possible implications for future management. J Cancer Res Clin Oncol. 130:383–387. 2004. View Article : Google Scholar : PubMed/NCBI

17 

El-Helw LM, Seckl MJ, Haynes R, Evans LS, Lorigan PC, Long J, Kanfer EJ, Newlands ES and Hancock BW: High-dose chemotherapy and peripheral blood stem cell support in refractory gestational trophoblastic neoplasia. Br J Cancer. 93:620–621. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Benigno BB: High-dose chemotherapy with autologous stem cell support as salvage therapy in recurrent gestational trophoblastic disease. Int J Gynecol Cancer. 23:1331–1333. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yamamoto E, Niimi K, Fujikake K, Nishida T, Murata M, Mitsuma A, Ando Y and Kikkawa F: High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review. Mol Clin Oncol 5: 660-664, 2016.
APA
Yamamoto, E., Niimi, K., Fujikake, K., Nishida, T., Murata, M., Mitsuma, A. ... Kikkawa, F. (2016). High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review. Molecular and Clinical Oncology, 5, 660-664. https://doi.org/10.3892/mco.2016.1011
MLA
Yamamoto, E., Niimi, K., Fujikake, K., Nishida, T., Murata, M., Mitsuma, A., Ando, Y., Kikkawa, F."High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review". Molecular and Clinical Oncology 5.5 (2016): 660-664.
Chicago
Yamamoto, E., Niimi, K., Fujikake, K., Nishida, T., Murata, M., Mitsuma, A., Ando, Y., Kikkawa, F."High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review". Molecular and Clinical Oncology 5, no. 5 (2016): 660-664. https://doi.org/10.3892/mco.2016.1011
Copy and paste a formatted citation
x
Spandidos Publications style
Yamamoto E, Niimi K, Fujikake K, Nishida T, Murata M, Mitsuma A, Ando Y and Kikkawa F: High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review. Mol Clin Oncol 5: 660-664, 2016.
APA
Yamamoto, E., Niimi, K., Fujikake, K., Nishida, T., Murata, M., Mitsuma, A. ... Kikkawa, F. (2016). High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review. Molecular and Clinical Oncology, 5, 660-664. https://doi.org/10.3892/mco.2016.1011
MLA
Yamamoto, E., Niimi, K., Fujikake, K., Nishida, T., Murata, M., Mitsuma, A., Ando, Y., Kikkawa, F."High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review". Molecular and Clinical Oncology 5.5 (2016): 660-664.
Chicago
Yamamoto, E., Niimi, K., Fujikake, K., Nishida, T., Murata, M., Mitsuma, A., Ando, Y., Kikkawa, F."High-dose chemotherapy with autologous peripheral blood stem cell transplantation for choriocarcinoma: A case report and literature review". Molecular and Clinical Oncology 5, no. 5 (2016): 660-664. https://doi.org/10.3892/mco.2016.1011
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