Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
November-2016 Volume 5 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2016 Volume 5 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Preclinical trial on the use of doxycycline for the treatment of adenocarcinoma of the duodenum

  • Authors:
    • Hector R. Galván‑Salazar
    • Alejandro D. Soriano‑Hernández
    • Daniel A. Montes‑Galindo
    • Gabriel Ceja Espíritu
    • José Guzman‑Esquivel
    • Iram P. Rodríguez‑Sánchez
    • Oscar A. Newton‑Sánchez
    • Margarita L. Martinez‑Fierro
    • Xóchitl G. Briseño Gómez
    • Augusto Rojas‑Martínez
    • Iván Delgado‑Enciso
  • View Affiliations / Copyright

    Affiliations: School of Medicine, University of Colima, Colima 28040, Mexico, State Cancer Institute, State Ministry of Health of Colima, Colima 28000, Mexico, Zone No. 1 General Hospital General of the Mexican Social Security Institute (IMSS), Colima 28000, Mexico, Department of Genetics, School of Medicine, Autonomous University of Nuevo León (UANL), Monterrey, Nuevo León 64460, Mexico, Molecular Medicine Laboratory, Academic Unit of Human Medicine and Health Sciences, Autonomous University of Zacatecas, Zacatecas 98160, Mexico, Center of Research and Development in Health Sciences and School of Medicine, UANL, Monterrey, Nuevo León 64460, Mexico
  • Pages: 657-659
    |
    Published online on: September 8, 2016
       https://doi.org/10.3892/mco.2016.1013
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Adenocarcinoma of the duodenum comprises 50‑70% of duodenal tumors. There is an increase in extracellular matrix metalloproteinases in this disease and it has been suggested that they play an important role in the development and pathology. Therefore, new therapeutic recommendations based on inhibitors of these enzymes, such as doxycycline, are under investigation. The cytotoxic effect of doxycycline was evaluated in the HuTu‑80 duodenal adenocarcinoma cell line and its antitumor effect was determined in an immunodeficient murine model. A 10‑µM (4.4 µg̸ml) concentration of doxycycline was capable of causing apoptosis in 90% of the culture cells. doxycycline was also responsible for a decrease in tumor growth and an increase in the survival of the mice with HuTu‑80‑cell tumors. These results suggest that doxycycline is a potential cytotoxic and antitumor agent effective in the treatment of adenocarcinoma of the duodenum.
View Figures

Figure 1

View References

1 

Bakaeen F, Murr MM, Sarr MG, Thompson GB, Farnell MB, Nagorney DM, Farley DR, van Heerden JA, Wiersema LM, Schleck CD and Donohue JH: What prognostic factors are important in duodenal adenocarcinoma? Arch Surg. 135:635–641; discussion 641–642. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Tocchi A, Mazzoni G, Puma F, Miccini M, Cassini D, Bettelli E and Tagliacozzo S: Adenocarcinoma of the third and fourth portions of the duodenum: Results of surgical treatment. Arch Surg. 138:80–85. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Hidalgo M and Eckhardt SG: Development of matrix metalloproteinase inhibitors in cancer therapy. J Natl Cancer Inst. 93:178–193. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Gu Y, Lee HM, Sorsa T, Salminen A, Ryan ME, Slepian MJ and Golub LM: Non-antibacterial tetracyclines modulate mediators of periodontitis and atherosclerotic cardiovascular disease: A mechanistic link between local and systemic inflammation. Pharmacol Res. 64:573–579. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Leite LM, Carvalho AG, Ferreira PL, Pessoa IX, Gonçalves DO, Ade A Lopes, Góes JG, Alves VC, Leal LK, Brito GA and Viana GS: Anti-inflammatory properties of doxycycline and minocycline in experimental models: An in vivo and in vitro comparative study. Inflammopharmacology. 19:99–110. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Jantzie LL and Todd KG: Doxycycline inhibits proinflammatory cytokines but not acute cerebral cytogenesis after hypoxia-ischemia in neonatal rats. J Psychiatry Neurosci. 35:20–32. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Osten L, Kubitza M, Gallagher AR, Kastner J, Olbrich H, de Vries U, Kees F, Lelongt B, Somlo S, Omran H and Witzgall R: Doxycycline accelerates renal cyst growth and fibrosis in the pcy/pcy mouse model of type 3 nephronophthisis, a form of recessive polycystic kidney disease. Histochem Cell Biol. 132:199–210. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Soriano-Hernández AD, Galvan-Salazar HR, Montes-Galindo DA, Rodriguez-Hernandez A, Martinez-Martinez R, Guzman-Esquivel J, Valdez-Velazquez LL, Baltazar-Rodriguez LM, Espinoza-Gómez F, Rojas-Martinez A, et al: Antitumor effect of meclofenamic acid on human androgen-independent prostate cancer: A preclinical evaluation. Int Urol Nephrol. 44:471–477. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Sagar J, Sales K, Dijk S, Taanman J, Seifalian A and Winslet M: Does doxycycline work in synergy with cisplatin and oxaliplatin in colorectal cancer? World J Surg Oncol. 7:22009. View Article : Google Scholar : PubMed/NCBI

10 

Onoda T, Ono T, Dhar DK, Yamanoi A, Fujii T and Nagasue N: Doxycycline inhibits cell proliferation and invasive potential: Combination therapy with cyclooxygenase-2 inhibitor in human colorectal cancer cells. J Lab Clin Med. 143:207–216. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Onoda T, Ono T, Dhar Dk, Yamanoi A and Nagasue N: Tetracycline analogues (doxycycline and COL-3) induce caspase-dependent and -independent apoptosis in human colon cancer cells. Int J Cancer. 118:1309–1315. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Lokeshwar BL, Selzer MG, Zhu BQ, Block NL and Golub LM: Inhibition of cell proliferation, invasion, tumor growth and metastasis by an oral non-antimicrobial tetracycline analog (COL-3) in a metastatic prostate cancer model. Int J Cancer. 98:297–309. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Wang A, Siegel E, Mayes DA, Hutchins LF and Yi Z: Anti-tumor effect of doxycycline on glioblastoma cells. Journal of Cancer Molecules. 3:147–153. 2007.

14 

Fife RS, Sledge GW Jr, Roth BJ and Proctor C: Effects of doxycycline on human prostate cancer cells in vitro. Cancer Lett. 127:37–41. 1998. View Article : Google Scholar : PubMed/NCBI

15 

Fife RS and Sledge GW Jr: Effects of doxycycline on in vitro growth, migration, and gelatinase activity of breast carcinoma cells. Lab Clin Med. 125:407–411. 1995.

16 

Fife RS, Rougraff TT, Proctor C and Sledge GW Jr: Inhibition of proliferation and induction of apoptosis by doxycycline in cultured human osteosarcoma cells. J Lab Clin Med. 130:530–534. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Bitik B, Kalpakci Y, Altan E, Dogan E and Altundag K: Successful treatment of primary duodenal carcinoma with bilateral adrenal metastases with docetaxel-cisplatin-5-fluorouracil regimen. Ann Oncol. 20:394–395. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Galván‑Salazar HR, Soriano‑Hernández AD, Montes‑Galindo DA, Ceja Espíritu G, Guzman‑Esquivel J, Rodríguez‑Sánchez IP, Newton‑Sánchez OA, Martinez‑Fierro ML, Briseño Gómez XG, Rojas‑Martínez A, Rojas‑Martínez A, et al: Preclinical trial on the use of doxycycline for the treatment of adenocarcinoma of the duodenum. Mol Clin Oncol 5: 657-659, 2016.
APA
Galván‑Salazar, H.R., Soriano‑Hernández, A.D., Montes‑Galindo, D.A., Ceja Espíritu, G., Guzman‑Esquivel, J., Rodríguez‑Sánchez, I.P. ... Delgado‑Enciso, I. (2016). Preclinical trial on the use of doxycycline for the treatment of adenocarcinoma of the duodenum. Molecular and Clinical Oncology, 5, 657-659. https://doi.org/10.3892/mco.2016.1013
MLA
Galván‑Salazar, H. R., Soriano‑Hernández, A. D., Montes‑Galindo, D. A., Ceja Espíritu, G., Guzman‑Esquivel, J., Rodríguez‑Sánchez, I. P., Newton‑Sánchez, O. A., Martinez‑Fierro, M. L., Briseño Gómez, X. G., Rojas‑Martínez, A., Delgado‑Enciso, I."Preclinical trial on the use of doxycycline for the treatment of adenocarcinoma of the duodenum". Molecular and Clinical Oncology 5.5 (2016): 657-659.
Chicago
Galván‑Salazar, H. R., Soriano‑Hernández, A. D., Montes‑Galindo, D. A., Ceja Espíritu, G., Guzman‑Esquivel, J., Rodríguez‑Sánchez, I. P., Newton‑Sánchez, O. A., Martinez‑Fierro, M. L., Briseño Gómez, X. G., Rojas‑Martínez, A., Delgado‑Enciso, I."Preclinical trial on the use of doxycycline for the treatment of adenocarcinoma of the duodenum". Molecular and Clinical Oncology 5, no. 5 (2016): 657-659. https://doi.org/10.3892/mco.2016.1013
Copy and paste a formatted citation
x
Spandidos Publications style
Galván‑Salazar HR, Soriano‑Hernández AD, Montes‑Galindo DA, Ceja Espíritu G, Guzman‑Esquivel J, Rodríguez‑Sánchez IP, Newton‑Sánchez OA, Martinez‑Fierro ML, Briseño Gómez XG, Rojas‑Martínez A, Rojas‑Martínez A, et al: Preclinical trial on the use of doxycycline for the treatment of adenocarcinoma of the duodenum. Mol Clin Oncol 5: 657-659, 2016.
APA
Galván‑Salazar, H.R., Soriano‑Hernández, A.D., Montes‑Galindo, D.A., Ceja Espíritu, G., Guzman‑Esquivel, J., Rodríguez‑Sánchez, I.P. ... Delgado‑Enciso, I. (2016). Preclinical trial on the use of doxycycline for the treatment of adenocarcinoma of the duodenum. Molecular and Clinical Oncology, 5, 657-659. https://doi.org/10.3892/mco.2016.1013
MLA
Galván‑Salazar, H. R., Soriano‑Hernández, A. D., Montes‑Galindo, D. A., Ceja Espíritu, G., Guzman‑Esquivel, J., Rodríguez‑Sánchez, I. P., Newton‑Sánchez, O. A., Martinez‑Fierro, M. L., Briseño Gómez, X. G., Rojas‑Martínez, A., Delgado‑Enciso, I."Preclinical trial on the use of doxycycline for the treatment of adenocarcinoma of the duodenum". Molecular and Clinical Oncology 5.5 (2016): 657-659.
Chicago
Galván‑Salazar, H. R., Soriano‑Hernández, A. D., Montes‑Galindo, D. A., Ceja Espíritu, G., Guzman‑Esquivel, J., Rodríguez‑Sánchez, I. P., Newton‑Sánchez, O. A., Martinez‑Fierro, M. L., Briseño Gómez, X. G., Rojas‑Martínez, A., Delgado‑Enciso, I."Preclinical trial on the use of doxycycline for the treatment of adenocarcinoma of the duodenum". Molecular and Clinical Oncology 5, no. 5 (2016): 657-659. https://doi.org/10.3892/mco.2016.1013
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team