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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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December-2016 Volume 5 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Case Report

Long-term disease stabilization following treatment with erlotinib in heavily pretreated patients with wild-type epidermal growth factor receptor non-small-cell lung carcinoma: Two case reports

  • Authors:
    • Minas Sakellakis
    • Angelos Koutras
    • Maria Pittaka
    • Efstathios Tsitsopoulos
    • Fotini Kalofonou
    • Haralabos P. Kalofonos
  • View Affiliations / Copyright

    Affiliations: Division of Oncology, Department of Medicine, University Hospital, Patras Medical School, 26504 Patras, Greece, Department of Radiation Oncology, University Hospital, Patras Medical School, 26504 Patras, Greece, Molecular Biology Diagnostic Center ‘Bioiatriki’, 11526 Athens, Greece
  • Pages: 803-806
    |
    Published online on: September 26, 2016
       https://doi.org/10.3892/mco.2016.1036
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Abstract

Lung adenocarcinomas carrying epidermal growth factor receptor (EGFR) mutations have been identified as a unique group of entities that depend on EGFR for their proliferation and metastasis. The introduction of reversible EGFR tyrosine kinase inhibitors, such as erlotinib, has significantly affected the management of metastatic disease in this subset of patients. Interestingly, although erlotinib is highly effective in patients with EGFR mutations, it may occasionally prove useful, even in the absence of mutations. We herein present the course of two heavily pretreated patients who achieved remarkable disease stabilization over several years, despite harbouring no EGFR mutations. Our cases underscore the fact that further research is required to identify which subset of patients will benefit the most from this treatment, as a substantial minority may present with favourable outcomes.
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Copy and paste a formatted citation
Spandidos Publications style
Sakellakis M, Koutras A, Pittaka M, Tsitsopoulos E, Kalofonou F and Kalofonos HP: Long-term disease stabilization following treatment with erlotinib in heavily pretreated patients with wild-type epidermal growth factor receptor non-small-cell lung carcinoma: Two case reports. Mol Clin Oncol 5: 803-806, 2016.
APA
Sakellakis, M., Koutras, A., Pittaka, M., Tsitsopoulos, E., Kalofonou, F., & Kalofonos, H.P. (2016). Long-term disease stabilization following treatment with erlotinib in heavily pretreated patients with wild-type epidermal growth factor receptor non-small-cell lung carcinoma: Two case reports. Molecular and Clinical Oncology, 5, 803-806. https://doi.org/10.3892/mco.2016.1036
MLA
Sakellakis, M., Koutras, A., Pittaka, M., Tsitsopoulos, E., Kalofonou, F., Kalofonos, H. P."Long-term disease stabilization following treatment with erlotinib in heavily pretreated patients with wild-type epidermal growth factor receptor non-small-cell lung carcinoma: Two case reports". Molecular and Clinical Oncology 5.6 (2016): 803-806.
Chicago
Sakellakis, M., Koutras, A., Pittaka, M., Tsitsopoulos, E., Kalofonou, F., Kalofonos, H. P."Long-term disease stabilization following treatment with erlotinib in heavily pretreated patients with wild-type epidermal growth factor receptor non-small-cell lung carcinoma: Two case reports". Molecular and Clinical Oncology 5, no. 6 (2016): 803-806. https://doi.org/10.3892/mco.2016.1036
Copy and paste a formatted citation
x
Spandidos Publications style
Sakellakis M, Koutras A, Pittaka M, Tsitsopoulos E, Kalofonou F and Kalofonos HP: Long-term disease stabilization following treatment with erlotinib in heavily pretreated patients with wild-type epidermal growth factor receptor non-small-cell lung carcinoma: Two case reports. Mol Clin Oncol 5: 803-806, 2016.
APA
Sakellakis, M., Koutras, A., Pittaka, M., Tsitsopoulos, E., Kalofonou, F., & Kalofonos, H.P. (2016). Long-term disease stabilization following treatment with erlotinib in heavily pretreated patients with wild-type epidermal growth factor receptor non-small-cell lung carcinoma: Two case reports. Molecular and Clinical Oncology, 5, 803-806. https://doi.org/10.3892/mco.2016.1036
MLA
Sakellakis, M., Koutras, A., Pittaka, M., Tsitsopoulos, E., Kalofonou, F., Kalofonos, H. P."Long-term disease stabilization following treatment with erlotinib in heavily pretreated patients with wild-type epidermal growth factor receptor non-small-cell lung carcinoma: Two case reports". Molecular and Clinical Oncology 5.6 (2016): 803-806.
Chicago
Sakellakis, M., Koutras, A., Pittaka, M., Tsitsopoulos, E., Kalofonou, F., Kalofonos, H. P."Long-term disease stabilization following treatment with erlotinib in heavily pretreated patients with wild-type epidermal growth factor receptor non-small-cell lung carcinoma: Two case reports". Molecular and Clinical Oncology 5, no. 6 (2016): 803-806. https://doi.org/10.3892/mco.2016.1036
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