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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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December-2016 Volume 5 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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Case Report

Immunoglobulin G4-mediated sclerosing cholangitis as a risk factor for cholangiocarcinoma: A case report

  • Authors:
    • Karin E. Koopman
    • Elisabeth Bloemena
    • Geert Kazemier
    • Michael Klemt‑Kropp
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Northwest Clinics, 1815 JD Alkmaar, The Netherlands, Department of Pathology, VU University Medical Center (VUMC), 1081 HV Amsterdam, The Netherlands, Department of Surgery, VU University Medical Center (VUMC), 1081 HV Amsterdam, The Netherlands
  • Pages: 786-788
    |
    Published online on: September 30, 2016
       https://doi.org/10.3892/mco.2016.1040
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Abstract

Immunoglobulin (Ig)G4-mediated disease is a systemic autoimmune disease, which occasionally presents solely as sclerosing cholangitis (SC). IgG4‑mediated SC is challenging to diagnose, as it may mimic cholangiocarcinoma radiologically, and carcinoma cells may produce IgG4. The diagnosis of IgG4‑mediated disease is based on histological consensus criteria and response to corticosteroids. In addition to the radiological and histological overlap between IgG4‑mediated SC and cholangiocarcinoma, IgG4‑mediated SC may be considered as a risk factor for the development of cholangiocarcinoma. We herein present the case of a patient in whom cholangiocarcinoma developed in two lesions previously characterized as IgG4‑mediated SC, including a suggested mechanism underlying the contribution of IgG4‑mediated SC to the development of cholangiocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Koopman KE, Bloemena E, Kazemier G and Klemt‑Kropp M: Immunoglobulin G4-mediated sclerosing cholangitis as a risk factor for cholangiocarcinoma: A case report. Mol Clin Oncol 5: 786-788, 2016.
APA
Koopman, K.E., Bloemena, E., Kazemier, G., & Klemt‑Kropp, M. (2016). Immunoglobulin G4-mediated sclerosing cholangitis as a risk factor for cholangiocarcinoma: A case report. Molecular and Clinical Oncology, 5, 786-788. https://doi.org/10.3892/mco.2016.1040
MLA
Koopman, K. E., Bloemena, E., Kazemier, G., Klemt‑Kropp, M."Immunoglobulin G4-mediated sclerosing cholangitis as a risk factor for cholangiocarcinoma: A case report". Molecular and Clinical Oncology 5.6 (2016): 786-788.
Chicago
Koopman, K. E., Bloemena, E., Kazemier, G., Klemt‑Kropp, M."Immunoglobulin G4-mediated sclerosing cholangitis as a risk factor for cholangiocarcinoma: A case report". Molecular and Clinical Oncology 5, no. 6 (2016): 786-788. https://doi.org/10.3892/mco.2016.1040
Copy and paste a formatted citation
x
Spandidos Publications style
Koopman KE, Bloemena E, Kazemier G and Klemt‑Kropp M: Immunoglobulin G4-mediated sclerosing cholangitis as a risk factor for cholangiocarcinoma: A case report. Mol Clin Oncol 5: 786-788, 2016.
APA
Koopman, K.E., Bloemena, E., Kazemier, G., & Klemt‑Kropp, M. (2016). Immunoglobulin G4-mediated sclerosing cholangitis as a risk factor for cholangiocarcinoma: A case report. Molecular and Clinical Oncology, 5, 786-788. https://doi.org/10.3892/mco.2016.1040
MLA
Koopman, K. E., Bloemena, E., Kazemier, G., Klemt‑Kropp, M."Immunoglobulin G4-mediated sclerosing cholangitis as a risk factor for cholangiocarcinoma: A case report". Molecular and Clinical Oncology 5.6 (2016): 786-788.
Chicago
Koopman, K. E., Bloemena, E., Kazemier, G., Klemt‑Kropp, M."Immunoglobulin G4-mediated sclerosing cholangitis as a risk factor for cholangiocarcinoma: A case report". Molecular and Clinical Oncology 5, no. 6 (2016): 786-788. https://doi.org/10.3892/mco.2016.1040
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