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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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December-2016 Volume 5 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Undifferentiated carcinoma of the gallbladder with endothelial differentiation: A case report and literature review

  • Authors:
    • Yoshitaka Furuya
    • Kenzo Hiroshima
    • Takashi Wakahara
    • Harutoshi Akimoto
    • Hironobu Yanagie
    • Kenichi Harigaya
    • Hiroshi Yasuhara
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Sodegaura Satsukidai Hospital, Chiba 299‑0246, Japan, Department of Pathology, Tokyo Women's Medical University Yachiyo Medical Center, Chiba 276‑8524, Japan, Department of Innovative Cancer Therapeutics, Alpha Particle and Immunotherapeutics, Meiji Pharmaceutical University, Tokyo 204‑8588, Japan, Department of Pathology, Graduate School of Medicine, Chiba University, Chiba 260‑8760, Japan, Surgical Center, University of Tokyo, Tokyo 113‑8655, Japan
  • Pages: 773-776
    |
    Published online on: October 5, 2016
       https://doi.org/10.3892/mco.2016.1046
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Abstract

Undifferentiated carcinoma of the gallbladder is a rare cancer type with a poor prognosis. The present study described a case of undifferentiated gallbladder carcinoma of the spindle‑ and giant‑cell type, according to the 2010 World Health Organization classification. Hematoxylin and eosin staining revealed that the tumor consisted of dense interlacing bundles of spindle‑shaped cells. No evidence of cartilaginous, osseous or rhabdomyosarcomatous differentiation was observed. Immunohistochemical staining revealed that spindle‑ and polygonal‑shaped cells of the undifferentiated carcinoma were positive for cytokeratin AE1/3, vimentin and vascular endothelial growth factor. Furthermore, numerous spindle‑shaped cells were positive for cluster of differentiation (CD)34 and CD31, and certain spindle‑shaped cells were positive for Factor VIII. These results suggested classification of the present case as ‘undifferentiated gallbladder carcinoma with endothelial differentiation’.
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Copy and paste a formatted citation
Spandidos Publications style
Furuya Y, Hiroshima K, Wakahara T, Akimoto H, Yanagie H, Harigaya K and Yasuhara H: Undifferentiated carcinoma of the gallbladder with endothelial differentiation: A case report and literature review. Mol Clin Oncol 5: 773-776, 2016.
APA
Furuya, Y., Hiroshima, K., Wakahara, T., Akimoto, H., Yanagie, H., Harigaya, K., & Yasuhara, H. (2016). Undifferentiated carcinoma of the gallbladder with endothelial differentiation: A case report and literature review. Molecular and Clinical Oncology, 5, 773-776. https://doi.org/10.3892/mco.2016.1046
MLA
Furuya, Y., Hiroshima, K., Wakahara, T., Akimoto, H., Yanagie, H., Harigaya, K., Yasuhara, H."Undifferentiated carcinoma of the gallbladder with endothelial differentiation: A case report and literature review". Molecular and Clinical Oncology 5.6 (2016): 773-776.
Chicago
Furuya, Y., Hiroshima, K., Wakahara, T., Akimoto, H., Yanagie, H., Harigaya, K., Yasuhara, H."Undifferentiated carcinoma of the gallbladder with endothelial differentiation: A case report and literature review". Molecular and Clinical Oncology 5, no. 6 (2016): 773-776. https://doi.org/10.3892/mco.2016.1046
Copy and paste a formatted citation
x
Spandidos Publications style
Furuya Y, Hiroshima K, Wakahara T, Akimoto H, Yanagie H, Harigaya K and Yasuhara H: Undifferentiated carcinoma of the gallbladder with endothelial differentiation: A case report and literature review. Mol Clin Oncol 5: 773-776, 2016.
APA
Furuya, Y., Hiroshima, K., Wakahara, T., Akimoto, H., Yanagie, H., Harigaya, K., & Yasuhara, H. (2016). Undifferentiated carcinoma of the gallbladder with endothelial differentiation: A case report and literature review. Molecular and Clinical Oncology, 5, 773-776. https://doi.org/10.3892/mco.2016.1046
MLA
Furuya, Y., Hiroshima, K., Wakahara, T., Akimoto, H., Yanagie, H., Harigaya, K., Yasuhara, H."Undifferentiated carcinoma of the gallbladder with endothelial differentiation: A case report and literature review". Molecular and Clinical Oncology 5.6 (2016): 773-776.
Chicago
Furuya, Y., Hiroshima, K., Wakahara, T., Akimoto, H., Yanagie, H., Harigaya, K., Yasuhara, H."Undifferentiated carcinoma of the gallbladder with endothelial differentiation: A case report and literature review". Molecular and Clinical Oncology 5, no. 6 (2016): 773-776. https://doi.org/10.3892/mco.2016.1046
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