Clear cell carcinoma of the lower uterine segment: A case report

Matoba,Yusuke; Kisu,Iori; Saotome,Keiko; Katayama,Motoko; Taniguchi,Makiko; Miura,Yumiko; Goto,Taeko; Hirao,Nobumaru

doi:10.3892/mco.2016.1048

December-2016 Volume 5 Issue 6

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December-2016 Volume 5 Issue 6

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Case Report Open Access

Clear cell carcinoma of the lower uterine segment: A case report

Authors:
- Yusuke Matoba
- Iori Kisu
- Keiko Saotome
- Motoko Katayama
- Makiko Taniguchi
- Yumiko Miura
- Taeko Goto
- Nobumaru Hirao
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, Tokyo 190-002, Japan

Copyright: © Matoba et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 701-704
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Published online on: October 11, 2016

https://doi.org/10.3892/mco.2016.1048
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Abstract

Uterine carcinoma of the lower uterine segment (LUS) is a rare tumor that accounts for 3-3.5% of cases of uterine malignant cancer. The tumor arises from the lower region of the uterine body through the upper region of the cervix. The present study reported a case of clear cell carcinoma that originated from the LUS. A 50-year‑old woman visited a local hospital due to irregular vaginal bleeding. She was suspected to have a uterine tumor and was referred to Tachikawa Hospital (Tokyo, Japan). Transvaginal ultrasound and magnetic resonance imaging revealed a uterine tumor from the lower region of the uterine body through the upper region of the cervix. Endocervical curettage revealed clear cell carcinoma. Based on a diagnosis of clear cell carcinoma of the LUS, radical hysterectomy was performed with bilateral salpingo-oophorectomy, paraaortic lymph node dissection and omentectomy. Macroscopically, the tumor was limited to the lower region of the uterine body through the upper region of the cervix in the resected uterus. Histopathological findings indicated no tumors in the uterine corpus and uterine cervix, but clear cell carcinoma was observed in the LUS epithelium. At the 1-year follow-up, the patient remained free of local recurrence and metastasis. To the best of our knowledge, clear cell carcinoma of the LUS has not previously been reported. More cases are required to clarify the pathology.

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1	Masuda K, Banno K, Yanokura M, Kobayashi Y, Kisu I, Ueki A, Ono A, Nomura H, Hirasawa A, Susumu N, et al: Carcinoma of the lower uterine segment (LUS): Clinicopathological characteristics and association with Lynch Syndrome. Curr Genomics. 12:25–29. 2011. View Article : Google Scholar : PubMed/NCBI
2	Haider MA, Patlas M, Jhaveri K, Chapman W, Fyles A and Rosen B: Adenocarcinoma involving the uterine cervix: Magnetic resonance imaging findings in tumours of endometrial, compared with cervical, origin. Can Assoc Radiol J. 57:43–48. 2006.PubMed/NCBI
3	Westin SN, Lacour RA, Urbauer DL, Luthra R, Bodurka DC, Lu KH and Broaddus RR: Carcinoma of the lower uterine segment: A newly described association with Lynch syndrome. J Clin Oncol. 26:5965–5971. 2008. View Article : Google Scholar : PubMed/NCBI
4	McCluggage WG, Sumathi VP, McBride HA and Patterson A: A panel of immunohistochemical stains, including carcinoembryonic antigen, vimentin, and estrogen receptor, aids the distinction between primary endometrial and endocervical adenocarcinomas. Int J Gynecol Pathol. 21:11–15. 2002. View Article : Google Scholar : PubMed/NCBI
5	Ansari-Lari MA, Staebler A, Zaino RJ, Shah KV and Ronnett BM: Distinction of endocervical and endometrial adenocarcinomas: Immunohistochemical p16 expression correlated with human papillomavirus (HPV) DNA detection. Am J Surg Pathol. 28:160–167. 2004. View Article : Google Scholar : PubMed/NCBI
6	Hasegawa K, Nagao S, Yasuda M, Millan D, Viswanathan AN, Glasspool RM, Devouassoux-Shisheboran M, Covens A, Lorusso D, Kurzeder C, et al: Gynecologic Cancer InterGroup (GCIG) consensus review for clear cell carcinoma of the uterine corpus and cervix. Int J Gynecol Cancer. 24:(Suppl 3). S90–S95. 2014. View Article : Google Scholar : PubMed/NCBI
7	Hachisuga T, Fukuda K, Iwasaka T, Hirakawa T, Kawarabayashi T and Tsuneyoshi M: Endometrioid adenocarcinomas of the uterine corpus in women younger than 50 years of age can be divided into two distinct clinical and pathologic entities based on anatomic location. Cancer. 92:2578–2584. 2001. View Article : Google Scholar : PubMed/NCBI
8	Watanabe Y, Nakajima H, Nozaki K, Ueda H, Obata K, Hoshiai H and Noda K: Clinicopathologic and immunohistochemical features and microsatellite status of endometrial cancer of the uterine isthmus. Int J Gynecol Pathol. 20:368–373. 2001. View Article : Google Scholar : PubMed/NCBI
9	Liao CL, Hsu JD, Lee MY, Kok LF, Li YJ, Wang PH, Yao CC and Han CP: Distinguishing between primary endocervical and endometrial adenocarcinomas: Is a 2-marker (Vim/CEA) panel enough? Virchows Arch. 456:377–386. 2010. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Clear cell carcinoma of the lower uterine segment: A case report

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