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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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Review

Human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer (Review)

  • Authors:
    • Lars Sivars
    • Cinzia Bersani
    • Nathalie Grün
    • Torbjörn Ramqvist
    • Eva Munck‑Wikland
    • Christian von Buchwald
    • Tina Dalianis
  • View Affiliations / Copyright

    Affiliations: Department of Oncology‑Pathology, Karolinska Institutet, Stockholm, Sweden, Department of Clinical, Technical Sciences and Intervention, Karolinska Institutet, Stockholm, Sweden, Department of Otolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Pages: 671-674
    |
    Published online on: October 13, 2016
       https://doi.org/10.3892/mco.2016.1050
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Abstract

Human papillomavirus (HPV), in addition to smoking and alcohol, is a cause of oropharyngeal squamous cell carcinoma (OPSCC), particularly of the tonsils and base of the tongue (TSCC and BOTSCC, respectively). Moreover, HPV‑positive TSCC and BOTSCC are associated with a better outcome compared with their HPV‑negative counterparts (80 vs. 40% 3‑year disease‑free survival rate, respectively) and their incidence has increased in several countries. Recently, accumulating evidence of HPV in a considerable proportion of cancers of unknown primary (CUP) in the head and neck region and in a small proportion of hypopharyngeal SCCs has been reported. Furthermore, HPV‑positive tumours, particularly cases with HPV DNA positivity in combination with overexpression of p16, also tend to have a better clinical outcome compared with that of the corresponding HPV‑negative tumours. This finding is particularly prominent in HPV‑positive CUPs of the head and neck region, where the primary tumour likely originates from the oropharynx. Thus, the determination of HPV status and p16 expression may be of value for the diagnosis and treatment of CUP of the head and neck region and may also be of value for hypopharyngeal cancers in the future. However, for hypopharyngeal cancer as well as other non‑OPSCCs, additional studies per subsite on the effect of HPV status on survival are required.
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1 

Dalianis T: Human papillomavirus and oropharyngeal cancer, the epidemics, and significance of additional clinical biomarkers for prediction of response to therapy (Review). Int J Oncol. 44:1799–1805. 2014.PubMed/NCBI

2 

Marklund L, Näsman A, Ramqvist T, Dalianis T, Munck-Wikland E and Hammarstedt L: Prevalence of human papillomavirus and survival in oropharyngeal cancer other than tonsil or base of tongue cancer. Cancer Med. 1:82–88. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Lindquist D, Romanitan M, Hammarstedt L, Näsman A, Dahlstrand H, Lindholm J, Onelöv L, Ramqvist T, Ye W, Munck-Wikland E and Dalianis T: Human papillomavirus is a favourable prognostic factor in tonsillar cancer and its oncogenic role is supported by the expression of E6 and E7. Mol Oncol. 1:350–335. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Attner P, Du J, Näsman A, Hammarstedt L, Ramqvist T, Lindholm J, Marklund L, Dalianis T and Munck-Wikland E: Human papillomavirus and survival in patients with base of tongue cancer. Int J Cancer. 128:2892–2897. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Sturgis EM and Cinciripini PM: Trends in head and neck cancer incidence in relation to smoking prevalence: An emerging epidemic of human papillomavirus-associated cancers? Cancer. 110:1429–1435. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Näsman A, Attner P, Hammarstedt L, Du J, Eriksson M, Giraud G, Ahrlund-Richter S, Marklund L, Romanitan M, Lindquist D, et al: Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral-induced carcinoma? Int J Cancer. 125:362–366. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, Jiang B, Goodman MT, Sibug-Saber M, Cozen W, et al: Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 29:4294–4301. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Channir HI, Rubek N, Nielsen HU, Kiss K, Charabi BW, Lajer CB and von Buchwald C: Transoral robotic surgery for the management of head and neck squamous cell carcinoma of unknown primary. Acta Otolaryngol. 135:1051–1057. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Tertipis N, Hammar U, Näsman A, Vlastos A, Nordfors C, Grün N, Ährlund-Richter A, Sivars L, Haeggblom L, Marklund L, et al: A model for predicting clinical outcome in patients with human papillomavirus-positive tonsillar and base of tongue cancer. Eur J Cancer. 51:1580–1587. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Begum S, Gillison ML, Nicol TL and Westra WH: Detection of human papillomavirus-16 in fine-needle aspirates to determine tumor origin in patients with metastatic squamous cell carcinoma of the head and neck. Clin Cancer Res. 13:1186–1191. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Compton AM, Moore-Medlin T, Herman-Ferdinandez L, Clark C, Caldito GC, Wang XI, Thomas J, Abreo FW and Nathan CO: Human papillomavirus in metastatic lymph nodes from unknown primary head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg. 145:51–57. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Tribius S, Hoffmann AS, Bastrop S, Görögh T, Haag J, Röcken C, Clauditz T, Grob T, Wilczak W, Tennstedt P, et al: HPV status in patients with head and neck of carcinoma of unknown primary site: HPV, tobacco smoking, and outcome. Oral Oncol. 48:1178–1184. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Park GC, Lee M, Roh JL, Yu MS, Choi SH, Nam SY, Kim SY and Cho KJ: Human papillomavirus and p16 detection in cervical lymph node metastases from an unknown primary tumor. Oral Oncol. 48:1250–1256. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Sivars L, Näsman A, Tertipis N, Vlastos A, Ramqvist T, Dalianis T, Munck-Wikland E and Nordemar S: Human papillomavirus and p53 expression in cancer of unknown primary in the head and neck region in relation to clinical outcome. Cancer Med. 3:376–384. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Jensen DH, Hedback N, Specht L, Høgdall E, Andersen E, Therkildsen MH, Friis-Hansen L, Norrild B and von Buchwald C: Human papillomavirus in head and neck squamous cell carcinoma of unknown primary is a common event and a strong predictor of survival. PLoS One. 9:e1104562014. View Article : Google Scholar : PubMed/NCBI

16 

Davis KS, Byrd JK, Mehta V, Chiosea SI, Kim S, Ferris RL, Johnson JT and Duvvuri U: Occult primary head and neck squamous cell carcinoma: Utility of discovering primary lesions. Otolaryngol Head Neck Surg. 151:272–278. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Boscolo-Rizzo P, Schroeder L, Romeo S and Pawlita M: The prevalence of human papillomavirus in squamous cell carcinoma of unknown primary site metastatic to neck lymph nodes: A systematic review. Clin Exp Metastasis. 32:835–845. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Hoffmann M, Görögh T, Gottschlich S, Lohrey C, Rittgen W, Ambrosch P, Schwarz E and Kahn T: Human papillomaviruses in head and neck cancer: 8 year-survival-analysis of 73 patients. Cancer Lett. 218:199–206. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Ernoux-Neufcoeur P, Arafa M, Decaestecker C, Duray A, Remmelink M, Leroy X, Herfs M, Somja J, Depuydt CE, Delvenne P and Saussez S: Combined analysis of HPV DNA, p16, p21 and p53 to predict prognosis in patients with stage IV hypopharyngeal carcinoma. J Cancer Res Clin Oncol. 137:173–181. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Wendt M, Romanitan M, Näsman A, Dalianis T, Hammarstedt L, Marklund L, Ramqvist T and Munck-Wikland E: Presence of human papillomaviruses and p16 expression in hypopharyngeal cancer. Head Neck. 36:107–112. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Ndiaye C, Mena M, Alemany L, Arbyn M, Castellsagué X, Laporte L, Bosch FX, de Sanjosé S and Trottier H: HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: A systematic review and meta-analysis. Lancet Oncol. 15:1319–1331. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Dalianis T, Grün N, Koch J, Vlastos A, Tertipis N, Nordfors C, Näsman A, Wendt M, Romanitan M, Bersani C, et al: Human papillomavirus DNA and p16(INK4a) expression in hypopharyngeal cancer and in relation to clinical outcome, in Stockholm, Sweden. Oral Oncol. 51:857–861. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Rodrigo JP, Hermsen MA, Fresno MF, Brakenhoff RH, García-Velasco F, Snijders PJ, Heideman DA and García-Pedrero JM: Prevalence of human papillomavirus in laryngeal and hypopharyngeal squamous cell carcinomas in northern Spain. Cancer Epidemiol. 39:37–41. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Joo YH, Lee YS, Cho KJ, Park JO, Nam IC, Kim CS, Kim SY and Kim MS: Characteristics and prognostic implications of high-risk HPV-associated hypopharyngeal cancers. PLoS One. 8:e787182013. View Article : Google Scholar : PubMed/NCBI

25 

Wilson DD, Rahimi AS, Saylor DK, Stelow EB, Jameson MJ, Shonka DC, Reibel JF, Levine PA and Read PW: p16 not a prognostic marker for hypopharyngeal squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 138:556–561. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Castellsagué X, Alemany L, Quer M, Halec G, Quirós B, Tous S, Clavero O, Alòs L, Biegner T, Szafarowski T, et al: HPV Involvement in head and neck cancers: Comprehensive assessment of biomarkers in 3680 patients. J Natl Cancer Inst. 108:djv4032016. View Article : Google Scholar : PubMed/NCBI

27 

Chung CH, Zhang Q, Kong CS, Harris J, Fertig EJ, Harari PM, Wang D, Redmond KP, Shenouda G, Trotti A, et al: p16 protein expression and human papillomavirus status as prognostic biomarkers of nonoropharyngeal head and neck squamous cell carcinoma. J Clini Oncol. 32:3930–3938. 2014. View Article : Google Scholar

28 

Shaughnessy JN, Farghaly H, Wilson L, Redman R, Potts K, Bumpous J, Silverman C and Dunlap NE: HPV: A factor in organ preservation for locally advanced larynx and hypopharynx cancer? Am J Otolaryngol. 35:19–24. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Young RJ, Urban D, Angel C, Corry J, Lyons B, Vallance N, Keid S, Iseli TA, Solomon B and Rischin D: Frequency and prognostic significance of p16(INK4A) protein overexpression and transcriptionally active human papillomavirus infection in laryngeal squamous cell carcinoma. Br J Cancer. 112:1098–1104. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sivars L, Bersani C, Grün N, Ramqvist T, Munck‑Wikland E, von Buchwald C and Dalianis T: Human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer (Review). Mol Clin Oncol 5: 671-674, 2016.
APA
Sivars, L., Bersani, C., Grün, N., Ramqvist, T., Munck‑Wikland, E., von Buchwald, C., & Dalianis, T. (2016). Human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer (Review). Molecular and Clinical Oncology, 5, 671-674. https://doi.org/10.3892/mco.2016.1050
MLA
Sivars, L., Bersani, C., Grün, N., Ramqvist, T., Munck‑Wikland, E., von Buchwald, C., Dalianis, T."Human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer (Review)". Molecular and Clinical Oncology 5.6 (2016): 671-674.
Chicago
Sivars, L., Bersani, C., Grün, N., Ramqvist, T., Munck‑Wikland, E., von Buchwald, C., Dalianis, T."Human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer (Review)". Molecular and Clinical Oncology 5, no. 6 (2016): 671-674. https://doi.org/10.3892/mco.2016.1050
Copy and paste a formatted citation
x
Spandidos Publications style
Sivars L, Bersani C, Grün N, Ramqvist T, Munck‑Wikland E, von Buchwald C and Dalianis T: Human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer (Review). Mol Clin Oncol 5: 671-674, 2016.
APA
Sivars, L., Bersani, C., Grün, N., Ramqvist, T., Munck‑Wikland, E., von Buchwald, C., & Dalianis, T. (2016). Human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer (Review). Molecular and Clinical Oncology, 5, 671-674. https://doi.org/10.3892/mco.2016.1050
MLA
Sivars, L., Bersani, C., Grün, N., Ramqvist, T., Munck‑Wikland, E., von Buchwald, C., Dalianis, T."Human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer (Review)". Molecular and Clinical Oncology 5.6 (2016): 671-674.
Chicago
Sivars, L., Bersani, C., Grün, N., Ramqvist, T., Munck‑Wikland, E., von Buchwald, C., Dalianis, T."Human papillomavirus is a favourable prognostic factor in cancer of unknown primary in the head and neck region and in hypopharyngeal cancer (Review)". Molecular and Clinical Oncology 5, no. 6 (2016): 671-674. https://doi.org/10.3892/mco.2016.1050
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