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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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Case Report

Successful treatment of anti-NMDA receptor encephalitis with a prompt ovarian tumour removal and prolonged course of plasmapheresis: A case report

  • Authors:
    • Elzbieta Rypulak
    • Michal Borys
    • Pawel Piwowarczyk
    • Magdalena Fijalkowska
    • Beata Potrec
    • Justyna Sysiak
    • Janusz Spustek
    • Alicja Bartkowska-Sniatkowska
    • Jan Kotarski
    • Waldemar A. Turski
    • Konrad Rejdak
    • Miroslaw Czuczwar
  • View Affiliations / Copyright

    Affiliations: The Second Department of Anaesthesiology and Intensive Therapy, Medical University of Lublin, Lublin, Poland, Department of Neurology, Neuropsychiatric Hospital, Lublin, Poland, Department of Paediatric Anaesthesiology and Intensive Therapy, Poznań University of Medical Sciences, Poznań, Poland, Department of Gynaecological Oncology and Gynaecology, Medical University of Lublin, Lublin, Poland, Department of Experimental and Clinical Pharmacology, Medical University of Lublin, Lublin, Poland, Department of Neurology, Medical University of Lublin, Lublin, Poland
  • Pages: 845-849
    |
    Published online on: October 19, 2016
       https://doi.org/10.3892/mco.2016.1054
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Abstract

Anti-N-methyl-d-aspartate-receptor (NMDAR) encephalitis is an uncommon autoimmune disorder with a wide spectrum of neuropsychiatric symptoms. There is a great requirement to emphasize the importance of a multidisciplinary team approach in the process of diagnosis and treatment of the potentially fatal condition, including psychiatrists, neurologists, gynaecologists and intensivists. Physicians must be aware that psychiatric and neurological disorders, which are typical features for NMDAR encephalitis in young women with ovarian tumours, may progress into status epilepticus and respiratory insufficiency. This disease can only be successfully treated with prompt surgical intervention and an early implementation of a wide array of immunosuppressive therapies. Optimal timing of initiation of therapeutic plasma exchange, as well as duration of treatment necessary to achieve desirable outcomes in patients with NMDAR remains unknown. The present case report aims to raise awareness about the importance of early implementation of this potentially life-saving therapy and continuing the treatment courses until full subsidence of symptoms.
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1 

Vitaliani R, Mason W, Ances B, Zwerdling T, Jiang Z and Dalmau J: Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol. 58:594–604. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Prüss H, Dalmau J, Harms L, Höltje M, Ahnert-Hilger G, Borowski K, Stoecker W and Wandinger KP: Retrospective analysis of NMDA receptor antibodies in encephalitis of unknown origin. Neurology. 75:1735–1739. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Barry H, Byrne S, Barrett E, Murphy KC and Cotter DR: Anti-N-methyl-d-aspartate receptor encephalitis: Review of clinical presentation, diagnosis and treatment. BJPsych Bull. 39:19–23. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Gwathmey K, Balogun RA and Burns T: Neurologic indications for therapeutic plasma exchange: 2013 update. J Clin Apher. 29:211–219. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Schmitt SE, Pargeon K, Frechette ES, Hirsch LJ, Dalmau J and Friedman D: Extreme delta brush: A unique EEG pattern in adults with anti-NMDA receptor encephalitis. Neurology. 79:1094–1100. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Zuliani L, Graus F, Giometto B, Bien C and Vincent A: Central nervous system neuronal surface antibody associated syndromes: Review and guidelines for recognition. J Neurol Neurosurg Psychiatry. 83:638–645. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Granerod J, Ambrose HE, Davies NW, Clewley JP, Walsh AL, Morgan D, Cunningham R, Zuckerman M, Mutton KJ, Solomon T, et al: UK Health Protection Agency (HPA) Aetiology of Encephalitis Study Group: Causes of encephalitis and differences in their clinical presentations in England: A multicentre, population-based prospective study. Lancet Infect Dis. 10:835–844. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Titulaer MJ, McCracken L, Gabilondo I, Armangué T, Glaser C, Iizuka T, Honig LS, Benseler SM, Kawachi I, Martinez-Hernandez E, et al: Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: An observational cohort study. Lancet Neurol. 12:157–165. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Irani SR, Bera K, Waters P, Zuliani L, Maxwell S, Zandi MS, Friese MA, Galea I, Kullmann DM, Beeson D, et al: N-methyl-D-aspartate antibody encephalitis: Temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain. 133:1655–1667. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, Dessain SK, Rosenfeld MR, Balice-Gordon R and Lynch DR: Anti-NMDA-receptor encephalitis: Case series and analysis of the effects of antibodies. Lancet Neurol. 7:1091–1098. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Motta E, Gołba A, Kazibutowska Z, Huć M and Stęposz A: Anti-NMDA receptor encephalitis-case report. Neurol Neurochir Pol. 46:288–293. 2012.(In Polish). PubMed/NCBI

12 

Hammer C, Stepniak B, Schneider A, Papiol S, Tantra M, Begemann M, Sirén AL, Pardo LA, Sperling S, Jofrry S Mohd, et al: Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry. 19:1143–1149. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Iizuka T, Sakai F, Ide T, Monzen T, Yoshii S, Iigaya M, Suzuki K, Lynch DR, Suzuki N, Hata T, et al: Anti-NMDA receptor encephalitis in Japan: Long-term outcome without tumor removal. Neurology. 70:504–511. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Peery HE, Day GS, Doja A, Xia C, Fritzler MJ and Foster WG: Anti-NMDA receptor encephalitis in children: The disorder, its diagnosis, and treatment. Handb Clin Neurol. 112:1229–1233. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Mann AP, Grebenciucova E and Lukas RV: Anti-N-methyl-D-aspartate-receptor encephalitis: Diagnosis, optimal management, and challenges. Ther Clin Risk Manag. 10:517–525. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Florance NR, Davis RL, Lam C, Szperka C, Zhou L, Ahmad S, Campen CJ, Moss H, Peter N, Gleichman AJ, et al: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol. 66:11–18. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR and Balice-Gordon R: Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. 10:63–74. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Zhang Y, Gao D, Ye H and Su Y: [Safety of plasma exchange therapy in patients with anti-NMDA receptor encephalitis. Zhonghua Yi Xue Za Zhi. 95:1505–1508. 2015.(In Chinese). PubMed/NCBI

19 

Shahani L: Steroid unresponsive anti-NMDA receptor encephalitis during pregnancy successfully treated with plasmapheresis. BMJ Case Rep 2015 (apr29 1). 292015.

20 

DeSena AD, Noland DK, Matevosyan K, King K, Phillips L, Qureshi SS, Greenberg BM and Graves D: Intravenous methylprednisolone versus therapeutic plasma exchange for treatment of anti-N-methyl-D-aspartate receptor antibody encephalitis: A retrospective review. J Clin Apher. 30:212–216. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Nunez-Enamorado N, Camacho-Salas A, Belda-Hofheinz S, Cordero-Castro C, Simon-De Las Heras R, Saiz-Diaz R, Martinez-Sarries FJ, Martinez-Menendez B and Graus F: Fast and spectacular clinical response to plasmapheresis in a paediatric case of anti-NMDA encephalitis. Rev Neurol. 54:420–424. 2012.(In Spanish). PubMed/NCBI

22 

Mirza MK, Pogoriler J, Paral K, Ananthanarayanan V, Mandal S, Mazin A, Baron B and Richa E: Adjunct therapeutic plasma exchange for anti-N-methyl-D-aspartate receptor antibody encephalitis: A case report and review of literature. J Clin Apher. 26:362–365. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Ikeguchi R, Shibuya K, Akiyama S, Hino S, Kubo H, Takeda T, Shibata N and Yamamoto K: Rituximab used successfully in the treatment of anti-NMDA receptor encephalitis. Intern Med. 51:1585–1589. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Schwartz J, Winters JL, Padmanabhan A, Balogun RA, Delaney M, Linenberger ML, Szczepiorkowski ZM, Williams ME, Wu Y and Shaz BH: Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Writing Committee of the American Society for Apheresis: The sixth special issue. J Clin Apher. 28:145–284. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Ehrlich S, Fassbender CM, Blaes C, Finke C, Günther A, Harms L, Hoffmann F, Jahner K, Klingel R, Kraft A, et al: Therapeutic apheresis for autoimmune encephalitis: A nationwide data collection. Nervenarzt. 84:498–507. 2013.(In German). View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Rypulak E, Borys M, Piwowarczyk P, Fijalkowska M, Potrec B, Sysiak J, Spustek J, Bartkowska-Sniatkowska A, Kotarski J, Turski WA, Turski WA, et al: Successful treatment of anti-NMDA receptor encephalitis with a prompt ovarian tumour removal and prolonged course of plasmapheresis: A case report. Mol Clin Oncol 5: 845-849, 2016.
APA
Rypulak, E., Borys, M., Piwowarczyk, P., Fijalkowska, M., Potrec, B., Sysiak, J. ... Czuczwar, M. (2016). Successful treatment of anti-NMDA receptor encephalitis with a prompt ovarian tumour removal and prolonged course of plasmapheresis: A case report. Molecular and Clinical Oncology, 5, 845-849. https://doi.org/10.3892/mco.2016.1054
MLA
Rypulak, E., Borys, M., Piwowarczyk, P., Fijalkowska, M., Potrec, B., Sysiak, J., Spustek, J., Bartkowska-Sniatkowska, A., Kotarski , J., Turski, W. A., Rejdak, K., Czuczwar, M."Successful treatment of anti-NMDA receptor encephalitis with a prompt ovarian tumour removal and prolonged course of plasmapheresis: A case report". Molecular and Clinical Oncology 5.6 (2016): 845-849.
Chicago
Rypulak, E., Borys, M., Piwowarczyk, P., Fijalkowska, M., Potrec, B., Sysiak, J., Spustek, J., Bartkowska-Sniatkowska, A., Kotarski , J., Turski, W. A., Rejdak, K., Czuczwar, M."Successful treatment of anti-NMDA receptor encephalitis with a prompt ovarian tumour removal and prolonged course of plasmapheresis: A case report". Molecular and Clinical Oncology 5, no. 6 (2016): 845-849. https://doi.org/10.3892/mco.2016.1054
Copy and paste a formatted citation
x
Spandidos Publications style
Rypulak E, Borys M, Piwowarczyk P, Fijalkowska M, Potrec B, Sysiak J, Spustek J, Bartkowska-Sniatkowska A, Kotarski J, Turski WA, Turski WA, et al: Successful treatment of anti-NMDA receptor encephalitis with a prompt ovarian tumour removal and prolonged course of plasmapheresis: A case report. Mol Clin Oncol 5: 845-849, 2016.
APA
Rypulak, E., Borys, M., Piwowarczyk, P., Fijalkowska, M., Potrec, B., Sysiak, J. ... Czuczwar, M. (2016). Successful treatment of anti-NMDA receptor encephalitis with a prompt ovarian tumour removal and prolonged course of plasmapheresis: A case report. Molecular and Clinical Oncology, 5, 845-849. https://doi.org/10.3892/mco.2016.1054
MLA
Rypulak, E., Borys, M., Piwowarczyk, P., Fijalkowska, M., Potrec, B., Sysiak, J., Spustek, J., Bartkowska-Sniatkowska, A., Kotarski , J., Turski, W. A., Rejdak, K., Czuczwar, M."Successful treatment of anti-NMDA receptor encephalitis with a prompt ovarian tumour removal and prolonged course of plasmapheresis: A case report". Molecular and Clinical Oncology 5.6 (2016): 845-849.
Chicago
Rypulak, E., Borys, M., Piwowarczyk, P., Fijalkowska, M., Potrec, B., Sysiak, J., Spustek, J., Bartkowska-Sniatkowska, A., Kotarski , J., Turski, W. A., Rejdak, K., Czuczwar, M."Successful treatment of anti-NMDA receptor encephalitis with a prompt ovarian tumour removal and prolonged course of plasmapheresis: A case report". Molecular and Clinical Oncology 5, no. 6 (2016): 845-849. https://doi.org/10.3892/mco.2016.1054
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