Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report

Horino,Taro; Ichii,Osamu; Hamada‑Ode,Kazu; Matsumoto,Tatsuki; Shimamura,Yoshiko; Inoue,Kosuke; Terada,Yoshio

doi:10.3892/mco.2016.1056

Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: A case report

Authors:
- Taro Horino
- Osamu Ichii
- Kazu Hamada‑Ode
- Tatsuki Matsumoto
- Yoshiko Shimamura
- Kosuke Inoue
- Yoshio Terada
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Affiliations: Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Nankoku, Kochi 783‑8505, Japan, Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido 060‑0818, Japan
Published online on: October 21, 2016 https://doi.org/10.3892/mco.2016.1056
Pages: 693-696
Copyright: © Horino et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Thyroid-like low‑grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is a rare neoplasm characterized by morphological analogy to papillary thyroid carcinoma and abnormal expression of thyroid transcription factor‑1 (TTF‑1). We herein report a rare case of TL‑LGNPPA with a review of its clinical, morphological and immunohistochemical characteristics. The patient was a 25‑year‑old Japanese woman complaining of a 2‑year history of fever of unknown origin. There were no remarkable physical findings and the laboratory tests, including C‑reactive protein levels, were normal. Laryngoscopy, magnetic resonance imaging and fluorodeoxyglucose‑positron emission tomography identified a pedunculated mass at the roof of the nasopharynx. Histologically, the tumour exhibited papillary growth of cuboidal or columnar epithelium. Tubular architecture and a spindle cell component were also observed focally. Some tumour cells exhibited intranuclear cytoplasmic inclusions. Immunohistochemically, the neoplastic cells were positive for TTF‑1, cytokeratin 7 and vimentin, but were negative for thyroglobulin. The Ki‑67 labelling index (MIB‑1 index) reached 5% in the most concentrated spot. The patient had neither local recurrence nor distant metastasis 3 years after removal of the tumour. In conclusion, TL‑LGNPPA should be included it in the differential diagnosis of fever of unknown origin.

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