Pulmonary intravascular large B‑cell lymphoma successfully treated with rituximab, cyclophosphamide, vincristine, doxorubicin and prednisolone immunochemotherapy: Report of a patient surviving for over 1 year

Nishii‑Ito,Shizuka; Izumi,Hiroki; Touge,Hirokazu; Takeda,Kenichi; Hosoda,Yuzuru; Yamasaki,Akira; Kuwamoto,Satoshi; Shimizu,Eiji; Motokura,Toru

doi:10.3892/mco.2016.1063

December-2016 Volume 5 Issue 6

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December-2016 Volume 5 Issue 6

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Article Open Access

Pulmonary intravascular large B‑cell lymphoma successfully treated with rituximab, cyclophosphamide, vincristine, doxorubicin and prednisolone immunochemotherapy: Report of a patient surviving for over 1 year

Authors:
- Shizuka Nishii‑Ito
- Hiroki Izumi
- Hirokazu Touge
- Kenichi Takeda
- Yuzuru Hosoda
- Akira Yamasaki
- Satoshi Kuwamoto
- Eiji Shimizu
- Toru Motokura
View Affiliations / Copyright

Affiliations: Department of Hematology, Tottori University Hospital, Yonago, Tottori 683‑8504, Japan, Division of Medical Oncology and Molecular Respirology, Department of Multidisciplinary Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Tottori 683‑8503, Japan, Division of Molecular Pathology, Department of Pathology, Faculty of Medicine, Tottori University, Yonago, Tottori 683‑8503, Japan

Copyright: © Nishii‑Ito et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 689-692
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Published online on: October 26, 2016

https://doi.org/10.3892/mco.2016.1063
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Abstract

A 73-year-old man with a history of lethargy, fever and dyspnea was admitted to Tottori University Hospital. A computed tomography (CT) scan revealed splenomegaly and diffusely spreading ground‑glass opacities (GGOs) in both lungs. A video‑assisted thoracoscopic surgery (VATS)‑guided lung biopsy revealed intravascular proliferation of large atypical lymphoid cells in the arteries, veins and alveolar walls. The patient was diagnosed with intravascular large B‑cell lymphoma (IVLBCL); he received 6 cycles of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R‑CHOP) immunochemotherapy and has remained in complete remission for >1 year. Although IVLBCL is a rare disease, it should be considered in the differential diagnosis of pulmonary diffuse lesions that present with GGOs on CT scans.

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