Lipomatous angiomyofibroblastoma of the vulva: A case report and review of the literature

Matsukuma,Susumu; Koga,Ayano; Suematsu,Ryohei; Takeo,Hiroaki; Sato,Kimiya

doi:10.3892/mco.2016.1078

January-2017 Volume 6 Issue 1

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January-2017 Volume 6 Issue 1

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Case Report

Lipomatous angiomyofibroblastoma of the vulva: A case report and review of the literature

Authors:
- Susumu Matsukuma
- Ayano Koga
- Ryohei Suematsu
- Hiroaki Takeo
- Kimiya Sato
View Affiliations / Copyright

Affiliations: Department of Pathology, Japan Self-Defense Forces Central Hospital, Tokyo 154-8532, Japan
Pages: 83-87
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Published online on: November 10, 2016

https://doi.org/10.3892/mco.2016.1078
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Abstract

Lipomatous angiomyofibroblastoma is extremely rare, with only 16 cases reported to date. We herein describe an additional case arising in the left vulvar region of a 49-year-old woman. The resected 5.3‑cm yellowish tumor predominantly consisted of fat cells (85% of the tumor), together with medium- and small-sized vessels, multifocal fibrotic areas and pseudoangiomatous spaces. Spindle, rounded, and/or epithelioid tumor cells proliferated in a nest and/or cord-like pattern, or singly within perivascular fibrous tissues and between fat cells. The tumor cells were positive for vimentin, estrogen receptor, progesterone receptor, B-cell lymphoma 2, and CD10, but were negative for desmin, cytokeratin, epithelial membrane antigen, S-100 protein, human melanoma black 45, C-kit and p40. Ultrastructural examination revealed that these tumor cells exhibited fibroblastic characteristics. Lipomatous angiomyofibroblastoma should be discriminated from other lipomatous tumors, including spindle cell lipoma, angiomyolipoma and cellular angiofibroma containing numerous fat cells.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Lipomatous angiomyofibroblastoma of the vulva: A case report and review of the literature

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