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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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January-2017 Volume 6 Issue 1

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International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Case Report

Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report

  • Authors:
    • Vanja Zeremski
    • Christian Mawrin
    • Thomas Fischer
    • Enrico Schalk
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, Medical Center, Otto‑von‑Guericke University Magdeburg, D‑39120 Magdeburg, Germany, Department of Neuropathology, Medical Center, Otto‑von‑Guericke University Magdeburg, D‑39120 Magdeburg, Germany
  • Pages: 79-82
    |
    Published online on: November 11, 2016
       https://doi.org/10.3892/mco.2016.1080
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Abstract

Yolk sac tumors (YSTs) are rare aggressive tumors, arising most commonly in the gonads and occurring mainly in young adults. We herein report a case of an extragonadal YST with hepatoid differentiation localized in the brain and lung. A 41‑year old man presented to our hospital with a generalized seizure. A head computed tomography and magnetic resonance imaging examination revealed a large mass in the left occipital lobe with associated edema. Following complete resection, the histopathological examination revealed that the mass was a highly malignant epithelial tumor with a hepatoid pattern. The serum lactate dehydrogenase and α‑fetoprotein levels were elevated. Additional diagnostic imaging revealed a lesion in the upper lobe of the right lung, but no other tumor manifestations. Based on the clinical and immunohistochemical characteristics, hepatocellular carcinoma and hepatoid adenocarcinoma were excluded and the diagnosis of extragonadal hepatoid YST was established. A multimodal therapeutic approach (high‑dose chemotherapy with autologous stem cell transplantation, radiation and surgery) was applied; however, the patient succumbed to refractory disease 10 months after the diagnosis. Therefore, the diagnosis and treatment of hepatoid YST is an interdisciplinary challenge.
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Copy and paste a formatted citation
Spandidos Publications style
Zeremski V, Mawrin C, Fischer T and Schalk E: Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report. Mol Clin Oncol 6: 79-82, 2017.
APA
Zeremski, V., Mawrin, C., Fischer, T., & Schalk, E. (2017). Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report. Molecular and Clinical Oncology, 6, 79-82. https://doi.org/10.3892/mco.2016.1080
MLA
Zeremski, V., Mawrin, C., Fischer, T., Schalk, E."Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report". Molecular and Clinical Oncology 6.1 (2017): 79-82.
Chicago
Zeremski, V., Mawrin, C., Fischer, T., Schalk, E."Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report". Molecular and Clinical Oncology 6, no. 1 (2017): 79-82. https://doi.org/10.3892/mco.2016.1080
Copy and paste a formatted citation
x
Spandidos Publications style
Zeremski V, Mawrin C, Fischer T and Schalk E: Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report. Mol Clin Oncol 6: 79-82, 2017.
APA
Zeremski, V., Mawrin, C., Fischer, T., & Schalk, E. (2017). Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report. Molecular and Clinical Oncology, 6, 79-82. https://doi.org/10.3892/mco.2016.1080
MLA
Zeremski, V., Mawrin, C., Fischer, T., Schalk, E."Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report". Molecular and Clinical Oncology 6.1 (2017): 79-82.
Chicago
Zeremski, V., Mawrin, C., Fischer, T., Schalk, E."Diagnostic and therapeutic challenges in extragonadal yolk sac tumor with hepatoid differentiation: A case report". Molecular and Clinical Oncology 6, no. 1 (2017): 79-82. https://doi.org/10.3892/mco.2016.1080
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