Rare virilizing granulosa cell tumor in an adolescent

Bús,Dorottya; Buzogány,Mária; Nagy,Gyöngyi; Vajda,György

doi:10.3892/mco.2016.1084

January-2017 Volume 6 Issue 1

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January-2017 Volume 6 Issue 1

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Article

Rare virilizing granulosa cell tumor in an adolescent

Authors:
- Dorottya Bús
- Mária Buzogány
- Gyöngyi Nagy
- György Vajda
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, Zala County Hospital, 8900 Zalaegerszeg, Hungary, Department of Neonatology and Pediatrics, Zala County Hospital, 8900 Zalaegerszeg, Hungary, Department of Radiology, Zala County Hospital, 8900 Zalaegerszeg, Hungary
Pages: 88-90
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Published online on: November 18, 2016

https://doi.org/10.3892/mco.2016.1084
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Abstract

Hormone‑producing malignancies are rare in children or adolescent patients: Only 0.1% of all ovarian tumors and 4-5% of granulosa cell tumors occur in the sexually non‑active ages. Granulosa cell tumors (GCTs) are sex cord‑stromal tumors of the ovary, representing 7-8% of all ovarian neoplasms. A total of 95% of all GCTs are adult‑type, and only 5% are diagnosed as juvenile‑type GCT. A majority of children with juvenile‑type GCT present with isosexual precocious pseudopuberty due to excessive estrogen production, although virilizing, testosterone‑producing, juvenile‑type GCTs are rare, occurring only in 2-3% of cases. The present case study reports on a case of a virilizing, juvenile‑type GCT in a 14-year-old girl, along with a review of the literature.

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1	Thrall MM, Paley P, Pizer E, Garcia R and Goff BA: Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. Gynecol Oncol. 122:242–245. 2011. View Article : Google Scholar : PubMed/NCBI
2	Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, et al: SEER Cancer Statistics Review, 1975–2012. National Cancer Institute; Bethesda, MD: http://seer.cancer.gov/csr/1975_2012
3	Horányi D, Koiss R, Babarczi E and Siklós P: A petefészek ivarléc-stroma eredetű daganatainak kezelésével szerzett tapasztalataink. Nőgyógyászati Onkológia. 16:40–42. 2011.
4	Csapó ZS, Szirmai K, Nagy GyR and Papp Z: Granulosa cell tumor (Retrospective study of 15 cases occuring during 15 years). Magyar Nőorvosok Lapja. 69:471–474. 2006.
5	Göcze P, Krommer K, Csermely T, Cziráky K, Garamvölgyi Z, Kovács K and Szabó I: Ovulation induction therapy and ovarian cancer. Orvo Hetil. 141:71–75. 2000.(In Hungarin).
6	Tanyi J, Rigó JR, Kis Csitári I and Csapó ZS: Juvenile granulosa cell tumor complicating pregnancy: Report of 2 cases. Magyar Nőorvosok Lapja. 61:451–454. 1998.
7	Haroon S, Idrees R, Zia A, Memon A, Fatima S and Kayani N: Ovarian sex cord stromal tumours in children and young girls-a more than two decade clinicopathological experience in a developing country, Pakistan. Asian Pac J Cancer Prev. 15:1351–1355. 2014. View Article : Google Scholar : PubMed/NCBI
8	Hashemipour M, Moaddab MH, Nazem M, Mahzouni P and Salek M: Granulosa cell tumor in a six-year-old girl presented as precocious puberty. J Res Med Sci. 15:240–242. 2010.PubMed/NCBI
9	Kabaca C, Karateke A, Gurbuz A and Cesur S: Androgenic adult granulosa cell tumor in a teenager: A case report and review of the literature. Int J Gynecol Cancer. 16:(Suppl 1). S368–S374. 2006. View Article : Google Scholar
10	François Y, Berlier P, Chatelain P and François R: Virilizing ovarian tumor in an adolescent. Pediatrie. 45:105–107. 1990.(In French). PubMed/NCBI
11	Patel SS, Carrick KS and Carr BR: Virilization persists in a woman with an androgen-secreting granulosa cell tumor. Fertil Steril. 91:933.e13–e15. 2009. View Article : Google Scholar
12	Ayhan A, Salman MC, Velipasaoglu M, Sakinci M and Yuce K: Prognostic factors in adult granulosa cell tumors of the ovary: A retrospective analysis of 80 cases. J Gynecol Oncol. 20:158–163. 2009. View Article : Google Scholar : PubMed/NCBI
13	Tai YJ, Chang WC, Kuo KT and Sheu BC: Ovarian steroid cell tumor, not otherwise specified, with virilization symptoms. Taiwan J Obstet Gynecol. 53:260–262. 2014. View Article : Google Scholar : PubMed/NCBI
14	Haroon NN, Agarwal G, Pandey R and Dabadghao P: Juvenile granulosa cell tumor presenting as isosexual precocious puberty: A case report and review of literature. Indian J Endocrinol Metab. 17:157–159. 2013. View Article : Google Scholar : PubMed/NCBI
15	Kota SK, Gayatri K, Pani JP, Meher LK, Kota SK and Modi KD: Ovarian granulosa cell tumor: An uncommon presentation with primary amenorrhea and virilization in a pubertal girl. Indian J Endocrinol Metab. 16:836–839. 2012. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Rare virilizing granulosa cell tumor in an adolescent

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