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Article

Complete response to azacitidine priming and nab‑paclitaxel in non‑Hodgkin lymphoma resistant to biochemotherapy

  • Authors:
    • Randy C. Bowen
    • Andrew W. Hahn
    • Thomas W. Butler
    • Hung T. Khong
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, University of Utah Salt Lake, UT 84112, USA, Department of Oncology, Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA, Department of Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake, UT 84112, USA
  • Pages: 122-124
    |
    Published online on: November 23, 2016
       https://doi.org/10.3892/mco.2016.1090
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Abstract

The standard of care for first‑line therapy in diffuse large B-cell lymphoma (DLBCL) is the rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R‑CHOP) regimen. For patients who fail to respond, have an incomplete response or relapse, numerous effective options exists besides salvage cisplatin‑based regimen and autologous stem cell therapy. Even with this approach, the outcome remains very poor for this group of patients. The present case illustrates a 55‑year‑old woman diagnosed with DLBCL, who experienced an early incomplete response, later progression during treatment with the R‑CHOP regimen. The patient received salvage therapy with rituximab, cisplatin and gemcitabine, again with an incomplete response. The patient declined consideration for stem cell therapy. Her disease progressed and she enrolled in the present phase I trial using azacitadine priming and nanoalbumin‑bound (nab)‑paclitaxel. After three cycles, follow‑up positron emission tomography/computed tomography revealed a complete response for the first time since her initial diagnosis and the patient has remained disease‑free for >6 years. Azacitadine and nab‑paclitaxel combination appeared to be an effective regimen for the treatment of this patient with refractory DLBCL.
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Copy and paste a formatted citation
Spandidos Publications style
Bowen RC, Hahn AW, Butler TW and Khong HT: Complete response to azacitidine priming and nab‑paclitaxel in non‑Hodgkin lymphoma resistant to biochemotherapy. Mol Clin Oncol 6: 122-124, 2017.
APA
Bowen, R.C., Hahn, A.W., Butler, T.W., & Khong, H.T. (2017). Complete response to azacitidine priming and nab‑paclitaxel in non‑Hodgkin lymphoma resistant to biochemotherapy. Molecular and Clinical Oncology, 6, 122-124. https://doi.org/10.3892/mco.2016.1090
MLA
Bowen, R. C., Hahn, A. W., Butler, T. W., Khong, H. T."Complete response to azacitidine priming and nab‑paclitaxel in non‑Hodgkin lymphoma resistant to biochemotherapy". Molecular and Clinical Oncology 6.1 (2017): 122-124.
Chicago
Bowen, R. C., Hahn, A. W., Butler, T. W., Khong, H. T."Complete response to azacitidine priming and nab‑paclitaxel in non‑Hodgkin lymphoma resistant to biochemotherapy". Molecular and Clinical Oncology 6, no. 1 (2017): 122-124. https://doi.org/10.3892/mco.2016.1090
Copy and paste a formatted citation
x
Spandidos Publications style
Bowen RC, Hahn AW, Butler TW and Khong HT: Complete response to azacitidine priming and nab‑paclitaxel in non‑Hodgkin lymphoma resistant to biochemotherapy. Mol Clin Oncol 6: 122-124, 2017.
APA
Bowen, R.C., Hahn, A.W., Butler, T.W., & Khong, H.T. (2017). Complete response to azacitidine priming and nab‑paclitaxel in non‑Hodgkin lymphoma resistant to biochemotherapy. Molecular and Clinical Oncology, 6, 122-124. https://doi.org/10.3892/mco.2016.1090
MLA
Bowen, R. C., Hahn, A. W., Butler, T. W., Khong, H. T."Complete response to azacitidine priming and nab‑paclitaxel in non‑Hodgkin lymphoma resistant to biochemotherapy". Molecular and Clinical Oncology 6.1 (2017): 122-124.
Chicago
Bowen, R. C., Hahn, A. W., Butler, T. W., Khong, H. T."Complete response to azacitidine priming and nab‑paclitaxel in non‑Hodgkin lymphoma resistant to biochemotherapy". Molecular and Clinical Oncology 6, no. 1 (2017): 122-124. https://doi.org/10.3892/mco.2016.1090
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