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Molecular and Clinical Oncology
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International Journal of Molecular Medicine

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

An increased neutrophil-to-lymphocyte ratio predicts poorer survival following recurrence for patients with breast cancer

  • Authors:
    • Toshiaki Iwase
    • Takafumi Sangai
    • Masahiro Sakakibara
    • Junta Sakakibara
    • Emi Ishigami
    • Shouko Hayama
    • Ayako Nakagawa
    • Takahito Masuda
    • Shunsuke Tabe
    • Takeshi Nagashima
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Chiba University Hospital, Chiba 2608677, Japan
  • Pages: 266-270
    |
    Published online on: December 5, 2016
       https://doi.org/10.3892/mco.2016.1101
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Abstract

The aim of the present study was to evaluate the association between changes in the neutrophil‑to‑lymphocyte ratio and the survival rate, as well as tumor subtype, in recurrent breast cancer. Patients with recurrent breast cancer following surgery were included in this study. NLR was calculated and compared between two time points: Pre‑treatment and recurrence. The associations between the longitudinal NLR change, the NLR at the time of recurrence and overall survival following recurrence (OSrec) were evaluated. A total of 89 patients were evaluated. NLR increased by 0.59 at recurrence, as compared with the initial treatment (P<0.05). The triple negative (TN) type demonstrated 4.59 in NLR, which was the highest among the four subtypes at the time of recurrence (P<0.05). The highest change (an increase of 2.0) was observed in TN type cancer (P<0.05). Patients with high NLR upon recurrence demonstrated significantly shorter OSrec rates (P<0.05). On the other hand, patients with an NLR increased by more than a third quartile demonstrated a shorter OSrec rate (P=0.06). When adjusted by covariates, the NLR and tumor subtype were determined to be associated with OSrec (P<0.05). Therefore, an increased NLR predicts survival, even in patients with recurrent breast cancer, and the NLR is potentially useful as an inflammation marker for TN breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Iwase T, Sangai T, Sakakibara M, Sakakibara J, Ishigami E, Hayama S, Nakagawa A, Masuda T, Tabe S, Nagashima T, Nagashima T, et al: An increased neutrophil-to-lymphocyte ratio predicts poorer survival following recurrence for patients with breast cancer. Mol Clin Oncol 6: 266-270, 2017.
APA
Iwase, T., Sangai, T., Sakakibara, M., Sakakibara, J., Ishigami, E., Hayama, S. ... Nagashima, T. (2017). An increased neutrophil-to-lymphocyte ratio predicts poorer survival following recurrence for patients with breast cancer. Molecular and Clinical Oncology, 6, 266-270. https://doi.org/10.3892/mco.2016.1101
MLA
Iwase, T., Sangai, T., Sakakibara, M., Sakakibara, J., Ishigami, E., Hayama, S., Nakagawa, A., Masuda, T., Tabe, S., Nagashima, T."An increased neutrophil-to-lymphocyte ratio predicts poorer survival following recurrence for patients with breast cancer". Molecular and Clinical Oncology 6.2 (2017): 266-270.
Chicago
Iwase, T., Sangai, T., Sakakibara, M., Sakakibara, J., Ishigami, E., Hayama, S., Nakagawa, A., Masuda, T., Tabe, S., Nagashima, T."An increased neutrophil-to-lymphocyte ratio predicts poorer survival following recurrence for patients with breast cancer". Molecular and Clinical Oncology 6, no. 2 (2017): 266-270. https://doi.org/10.3892/mco.2016.1101
Copy and paste a formatted citation
x
Spandidos Publications style
Iwase T, Sangai T, Sakakibara M, Sakakibara J, Ishigami E, Hayama S, Nakagawa A, Masuda T, Tabe S, Nagashima T, Nagashima T, et al: An increased neutrophil-to-lymphocyte ratio predicts poorer survival following recurrence for patients with breast cancer. Mol Clin Oncol 6: 266-270, 2017.
APA
Iwase, T., Sangai, T., Sakakibara, M., Sakakibara, J., Ishigami, E., Hayama, S. ... Nagashima, T. (2017). An increased neutrophil-to-lymphocyte ratio predicts poorer survival following recurrence for patients with breast cancer. Molecular and Clinical Oncology, 6, 266-270. https://doi.org/10.3892/mco.2016.1101
MLA
Iwase, T., Sangai, T., Sakakibara, M., Sakakibara, J., Ishigami, E., Hayama, S., Nakagawa, A., Masuda, T., Tabe, S., Nagashima, T."An increased neutrophil-to-lymphocyte ratio predicts poorer survival following recurrence for patients with breast cancer". Molecular and Clinical Oncology 6.2 (2017): 266-270.
Chicago
Iwase, T., Sangai, T., Sakakibara, M., Sakakibara, J., Ishigami, E., Hayama, S., Nakagawa, A., Masuda, T., Tabe, S., Nagashima, T."An increased neutrophil-to-lymphocyte ratio predicts poorer survival following recurrence for patients with breast cancer". Molecular and Clinical Oncology 6, no. 2 (2017): 266-270. https://doi.org/10.3892/mco.2016.1101
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