Raynaud's of the tongue following chemoradiation for squamous cell carcinoma of the oropharynx

Mittal,Amit; Mittal,Bharat B.

doi:10.3892/mco.2016.1103

February-2017 Volume 6 Issue 2

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February-2017 Volume 6 Issue 2

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Article

Raynaud's of the tongue following chemoradiation for squamous cell carcinoma of the oropharynx

Authors:
- Amit Mittal
- Bharat B. Mittal
View Affiliations / Copyright

Affiliations: Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510, USA, Department of Radiation Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611, USA
Pages: 187-188
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Published online on: December 7, 2016

https://doi.org/10.3892/mco.2016.1103
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Abstract

Raynaud's of the tongue following radiation alone or chemoradiotherapy (CRT) is a rare occurrence. The present study reports a case where typical symptoms and signs of Raynaud's phenomenon involving the tongue occurred ~18 months following CRT treatment in a 53‑year‑old female, who was a smoker prior to CRT with stage T2N2cM0 local‑regional advanced stage IV oropharyngeal cancer. The patient was treated using cisplatin chemotherapy and intensity‑modulated radiation with a dose of 70 Gray (Gy). The intermittent episodes of painful discoloration of the tongue were exacerbated due to the cold and emotional stress. No definite clinical or laboratory evidence of connective tissue disorder was identified. To the best of our knowledge, this is the first reported case of Raynaud's of the tongue following CRT without primary Raynaud's of the digits. The possible pathogenesis involving vascular and neural mechanism is discussed in the case report.

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1	Herrick AL: The pathogenesis, diagnosis and treatment of Raynaud phenomenon. Nat Rev Rheumatol. 8:469–479. 2012. View Article : Google Scholar : PubMed/NCBI
2	Herrick AL, Illingworth K, Blann A, Hay CR, Hollis S and Jayson MI: Von Willebrand factor, thrombomodulin, thromboxane, beta-thromboglobulin and markers of fibrinolysis in primary Raynaud's phenomenon and systemic sclerosis. Ann Rheum Dis. 55:122–127. 1996. View Article : Google Scholar : PubMed/NCBI
3	Giunta JL: Raynaud disease with oral manifestations. Arch Dermatol. 111:78–80. 1975. View Article : Google Scholar : PubMed/NCBI
4	Katada Y and Tanaka T: Images in clinical medicine. Lingual Raynaud's phenomenon. N Engl J Med. 366:e122012. View Article : Google Scholar : PubMed/NCBI
5	Cohen JC, Palomba ML and Morris LG: Raynaud's phenomenon of the tongue. J Rheumatol. 40:3362013. View Article : Google Scholar : PubMed/NCBI
6	Westbury CB, Harrington KJ, Rhys-Evans P, Archer DJ, Searle AE, Henk JM, Black CM and Nutting CM: Raynaud's phenomenon after radical radiotherapy for tumours of the head and neck. Postgrad Med J. 79:176–177. 2003. View Article : Google Scholar : PubMed/NCBI
7	Mohokum M, Hartmann P and Schlattmann P: The association of Raynaud's syndrome with cisplatin-based chemotherapy - a meta-analysis. Eur J Intern Med. 23:594–598. 2012. View Article : Google Scholar : PubMed/NCBI
8	Vogelzang NJ, Bosl GJ, Johnson K and Kennedy BJ: Raynaud's phenomenon: A common toxicity after combination chemotherapy for testicular cancer. Ann Intern Med. 95:288–292. 1981. View Article : Google Scholar : PubMed/NCBI
9	Stefenelli T, Kuzmits R, Ulrich W and Glogar D: Acute vascular toxicity after combination chemotherapy with cisplatin, vinblastine, and bleomycin for testicular cancer. Eur Heart J. 9:552–556. 1988.PubMed/NCBI
10	Pliarchopoulou K and Pectasides D: Late complications of chemotherapy in testicular cancer. Cancer Treat Rev. 36:262–267. 2010. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Raynaud's of the tongue following chemoradiation for squamous cell carcinoma of the oropharynx

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