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Article

Paclitaxel and platinum‑based chemotherapy results in transient dyslipidemia in cancer patients

  • Authors:
    • Guoping Wang
    • Chao Su
    • Tao Yin
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, P.R. China
  • Pages: 261-265
    |
    Published online on: December 13, 2016
       https://doi.org/10.3892/mco.2016.1107
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Abstract

Paclitaxel and cisplatin (TP) are common chemotherapeutic agents extensively used for treating lung and esophageal cancers. The present study reported three patients with transient hypertriglyceridemia (HTG) following TP chemotherapy. Serum triglyceride (TG) levels returned to baseline at chemotherapy intermission. No patient had any history of HTG or any evidence of pancreatitis or other complications of HTG. No regular elevation of any other serum lipids, including cholesterol, high‑density lipoprotein and low‑density lipoprotein, was observed. However, treatment of mice with TP decreased TG and slightly increased cholesterol. The findings of the present study suggested that TP chemotherapy results in transient dyslipidemia, and physicians must monitor TG levels during chemotherapy to avoid TG‑associated complications.
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1 

Fearon KC, Glass DJ and Guttridge DC: Cancer cachexia: Mediators, signaling, and metabolic pathways. Cell Metab. 16:153–166. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Landen CN Jr, Birrer MJ and Sood AK: Early events in the pathogenesis of epithelial ovarian cancer. J Clin Oncol. 26:995–1005. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, et al: Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med. 17:1498–1503. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Zhang Y, Daquinag AC, Amaya-Manzanares F, Sirin O, Tseng C and Kolonin MG: Stromal progenitor cells from endogenous adipose tissue contribute to pericytes and adipocytes that populate the tumor microenvironment. Cancer Res. 72:5198–5208. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Dirat B, Bochet L, Dabek M, Daviaud D, Dauvillier S, Majed B, Wang YY, Meulle A, Salles B, Le Gonidec S, et al: Cancer-associated adipocytes exhibit an activated phenotype and contribute to breast cancer invasion. Cancer Res. 71:2455–2465. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, Sullivan SA, Nichols AG and Rathmell JC: Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol. 186:3299–3303. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Huang SC, Everts B, Ivanova Y, O'Sullivan D, Nascimento M, Smith AM, Beatty W, Love-Gregory L, Lam WY, O'Neill CM, et al: Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages. Nat Immunol. 15:846–855. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Pencheva N, Tran H, Buss C, Huh D, Drobnjak M, Busam K and Tavazoie SF: Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis. Cell. 151:1068–1082. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Fang L, Choi SH, Baek JS, Liu C, Almazan F, Ulrich F, Wiesner P, Taleb A, Deer E, Pattison J, et al: Control of angiogenesis by AIBP-mediated cholesterol efflux. Nature. 498:118–122. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Ito Y, Azrolan N, O'Connell A, Walsh A and Breslow JL: Hypertriglyceridemia as a result of human apo CIII gene expression in transgenic mice. Science. 249:790–793. 1990. View Article : Google Scholar : PubMed/NCBI

11 

Hsia SH, Connelly PW and Hegele RA: Successful outcome in severe pregnancy-associated hyperlipemia: A case report and literature review. Am J Med Sci. 309:213–218. 1995. View Article : Google Scholar : PubMed/NCBI

12 

Calza L, Manfredi R and Chiodo F: Dyslipidaemia associated with antiretroviral therapy in HIV-infected patients. J Antimicrob Chemother. 53:10–14. 2004. View Article : Google Scholar : PubMed/NCBI

13 

Austin MA: Plasma triglyceride and coronary heart disease. Arterioscler Thromb. 11:2–14. 1991. View Article : Google Scholar : PubMed/NCBI

14 

Reaven GM: Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 37:1595–1607. 1988. View Article : Google Scholar : PubMed/NCBI

15 

Maher NG and Ramaswamykanive H: Use of plasmapheresis in managing the diagnostic dilemma of symptomatic hypertriglyceridemia. Case Rep Gastrointest Med. 2012:5013732012.PubMed/NCBI

16 

Kyriakidis AV, Raitsiou B, Sakagianni A, Harisopoulou V, Pyrgioti M, Panagopoulou A, Vasilakis N and Lambropoulos S: Management of acute severe hyperlipidemic pancreatitis. Digestion. 73:259–264. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Athyros VG, Giouleme OI, Nikolaidis NL, Vasiliadis TV, Bouloukos VI, Kontopoulos AG and Eugenidis NP: Long-term follow-up of patients with acute hypertriglyceridemia-induced pancreatitis. J Clin Gastroenterol. 34:472–475. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Yadav D and Pitchumoni CS: Issues in hyperlipidemic pancreatitis. J Clin Gastroenterol. 36:54–62. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Bollen TL, van Santvoort HC, Besselink MG, van Leeuwen MS, Horvath KD, Freeny PC and Gooszen HG: Dutch Acute Pancreatitis Study Group: The Atlanta Classification of acute pancreatitis revisited. Br J Surg. 95:6–21. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Subramanian S and Chait A: Hypertriglyceridemia secondary to obesity and diabetes. Biochim Biophys Acta. 1821:819–825. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Blumenschein GR Jr, Khuri FR, von Pawel J, Gatzemeier U, Miller WH Jr, Jotte RM, Le Treut J, Sun SL, Zhang JK, Dziewanowska ZE and Negro-Vilar A: Phase III trial comparing carboplatin, paclitaxel, and bexarotene with carboplatin and paclitaxel in chemotherapy-naive patients with advanced or metastatic non-small-cell lung cancer: SPIRIT II. J Clin Oncol. 26:1879–1885. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Gan SI, Edwards AL, Symonds CJ and Beck PL: Hypertriglyceridemia-induced pancreatitis. A case-based review. World J Gastroenterol. 12:7197–7202. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Jain P, Rai RR, Udawat H, Nijhawan S and Mathur A: Insulin and heparin in treatment of hypertriglyceridemia-induced pancreatitis. World J Gastroenterol. 13:2642–2643. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Markota A, Knehtl M, Sinkovic A, Ekart R, Hojs R and Bevc S: Plasma exchange treatment for acute hyperlipidemic pancreatitis with falsely low levels of serum triglycerides- a case report. Transfus Apher Sci. 51:178–180. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Monib SM and El-Barbary HM: Acute relapsing pancreatitis with pseudocyst formation due to sporadic hypertriglyceridemic pancreatitis: A case report. Indian J Surg. 75:(Suppl 1). S340–S344. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang G, Su C and Yin T: Paclitaxel and platinum‑based chemotherapy results in transient dyslipidemia in cancer patients. Mol Clin Oncol 6: 261-265, 2017.
APA
Wang, G., Su, C., & Yin, T. (2017). Paclitaxel and platinum‑based chemotherapy results in transient dyslipidemia in cancer patients. Molecular and Clinical Oncology, 6, 261-265. https://doi.org/10.3892/mco.2016.1107
MLA
Wang, G., Su, C., Yin, T."Paclitaxel and platinum‑based chemotherapy results in transient dyslipidemia in cancer patients". Molecular and Clinical Oncology 6.2 (2017): 261-265.
Chicago
Wang, G., Su, C., Yin, T."Paclitaxel and platinum‑based chemotherapy results in transient dyslipidemia in cancer patients". Molecular and Clinical Oncology 6, no. 2 (2017): 261-265. https://doi.org/10.3892/mco.2016.1107
Copy and paste a formatted citation
x
Spandidos Publications style
Wang G, Su C and Yin T: Paclitaxel and platinum‑based chemotherapy results in transient dyslipidemia in cancer patients. Mol Clin Oncol 6: 261-265, 2017.
APA
Wang, G., Su, C., & Yin, T. (2017). Paclitaxel and platinum‑based chemotherapy results in transient dyslipidemia in cancer patients. Molecular and Clinical Oncology, 6, 261-265. https://doi.org/10.3892/mco.2016.1107
MLA
Wang, G., Su, C., Yin, T."Paclitaxel and platinum‑based chemotherapy results in transient dyslipidemia in cancer patients". Molecular and Clinical Oncology 6.2 (2017): 261-265.
Chicago
Wang, G., Su, C., Yin, T."Paclitaxel and platinum‑based chemotherapy results in transient dyslipidemia in cancer patients". Molecular and Clinical Oncology 6, no. 2 (2017): 261-265. https://doi.org/10.3892/mco.2016.1107
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