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Article

Hepatectomy combined with microwave ablation of the spleen for treatment of hepatocellular carcinoma complicated with splenomegaly: A retrospective study

  • Authors:
    • Jian‑Bo Han
    • Feng‑Wei Kong
    • Hai Ding
    • Yu‑Feng Zhang
    • Jun‑Mao Liu
    • Qiang Wei
    • Liang Hu
    • Liang Zhao
    • Chuan‑Jun Xu
    • Yong‑Xiang Yi
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing, Jiangsu 210003, P.R. China, Department of General Surgery, Xuzhou Infectious Diseases Hospital, Xuzhou, Jiangsu 221004, P.R. China, Department of Interventional Ultrasound, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing, Jiangsu 210003, P.R. China, Department of Medical Imaging, The Second Hospital of Nanjing, Affiliated to Southeast University, Nanjing, Jiangsu 210003, P.R. China
  • Pages: 204-208
    |
    Published online on: December 14, 2016
       https://doi.org/10.3892/mco.2016.1111
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Abstract

The present retrospective study aimed to investigate the mid‑term safety and efficacy of hepatectomy combined with microwave ablation of the partial spleen for treatment of liver cancer complicated with hypersplenism. A retrospective analysis was performed on 23 patients who underwent hepatectomy combined with microwave ablation of the partial spleen for liver cancer, complicated with hypersplenism that was secondary to cirrhosis. The splenic and ablated volumes were calculated according to a contrast‑enhanced computed tomography scan prior to and 2 weeks after the operation. Complete blood count and liver function tests were examined prior to and following the surgery, and complications and changes in the blood tests were monitored for 6 months. Over this period of investigation, the splenic volume was reduced by a mean value of 34.0%. The levels of serum alanine aminotransferase and aspartate aminotransferase were increased on the first day after the operation (P<0.05), although they recovered to the normal level within 1 week (P<0.05). The total level of bilirubin increased slightly, along with moderately decreased levels of albumin and cholinesterase on the first day, although these changes were not significant compared with the baseline (P>0.05). The white blood cell count was persistently significantly higher compared with the baseline over the course of the 6 months (P>0.05). The platelet count did not increase significantly for the first week after the operation (P>0.05); however, it was revealed to be significantly increased 1 month after the surgery (P<0.05). No significant complications were occurred during the follow‑up period. In conclusion, hepatectomy combined with microwave ablation of the spleen was demonstrated to be a safe and effective procedure for patients with liver cancer and hypersplenism in the mid-term.
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Copy and paste a formatted citation
Spandidos Publications style
Han JB, Kong FW, Ding H, Zhang YF, Liu JM, Wei Q, Hu L, Zhao L, Xu CJ, Yi YX, Yi YX, et al: Hepatectomy combined with microwave ablation of the spleen for treatment of hepatocellular carcinoma complicated with splenomegaly: A retrospective study. Mol Clin Oncol 6: 204-208, 2017.
APA
Han, J., Kong, F., Ding, H., Zhang, Y., Liu, J., Wei, Q. ... Yi, Y. (2017). Hepatectomy combined with microwave ablation of the spleen for treatment of hepatocellular carcinoma complicated with splenomegaly: A retrospective study. Molecular and Clinical Oncology, 6, 204-208. https://doi.org/10.3892/mco.2016.1111
MLA
Han, J., Kong, F., Ding, H., Zhang, Y., Liu, J., Wei, Q., Hu, L., Zhao, L., Xu, C., Yi, Y."Hepatectomy combined with microwave ablation of the spleen for treatment of hepatocellular carcinoma complicated with splenomegaly: A retrospective study". Molecular and Clinical Oncology 6.2 (2017): 204-208.
Chicago
Han, J., Kong, F., Ding, H., Zhang, Y., Liu, J., Wei, Q., Hu, L., Zhao, L., Xu, C., Yi, Y."Hepatectomy combined with microwave ablation of the spleen for treatment of hepatocellular carcinoma complicated with splenomegaly: A retrospective study". Molecular and Clinical Oncology 6, no. 2 (2017): 204-208. https://doi.org/10.3892/mco.2016.1111
Copy and paste a formatted citation
x
Spandidos Publications style
Han JB, Kong FW, Ding H, Zhang YF, Liu JM, Wei Q, Hu L, Zhao L, Xu CJ, Yi YX, Yi YX, et al: Hepatectomy combined with microwave ablation of the spleen for treatment of hepatocellular carcinoma complicated with splenomegaly: A retrospective study. Mol Clin Oncol 6: 204-208, 2017.
APA
Han, J., Kong, F., Ding, H., Zhang, Y., Liu, J., Wei, Q. ... Yi, Y. (2017). Hepatectomy combined with microwave ablation of the spleen for treatment of hepatocellular carcinoma complicated with splenomegaly: A retrospective study. Molecular and Clinical Oncology, 6, 204-208. https://doi.org/10.3892/mco.2016.1111
MLA
Han, J., Kong, F., Ding, H., Zhang, Y., Liu, J., Wei, Q., Hu, L., Zhao, L., Xu, C., Yi, Y."Hepatectomy combined with microwave ablation of the spleen for treatment of hepatocellular carcinoma complicated with splenomegaly: A retrospective study". Molecular and Clinical Oncology 6.2 (2017): 204-208.
Chicago
Han, J., Kong, F., Ding, H., Zhang, Y., Liu, J., Wei, Q., Hu, L., Zhao, L., Xu, C., Yi, Y."Hepatectomy combined with microwave ablation of the spleen for treatment of hepatocellular carcinoma complicated with splenomegaly: A retrospective study". Molecular and Clinical Oncology 6, no. 2 (2017): 204-208. https://doi.org/10.3892/mco.2016.1111
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