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Review

Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas (Review)

  • Authors:
    • Giuseppina Della Vittoria Scarpati
    • Francesco Perri
    • Salvatore Pisconti
    • Giuseppe Costa
    • Filippo Ricciardiello
    • Salvatore Del Prete
    • Alberto Napolitano
    • Marco Carraturo
    • Salvatore Mazzone
    • Raffaele Addeo
  • View Affiliations / Copyright

    Affiliations: D.A.I. Diagnostica Morfologica e Funzionale, Radioterapia e Medicina Legale, Università degli Studi di Napoli ‘Ferderico II’, Ι‑80138 Napoli, Italy, Unità Operativa di Oncologia, Ospedale ‘San Giuseppe Moscati’ di Taranto, Ι‑74100 Taranto, Italy, Dipartimento di Salute Mentale Fisica e Medicina Preventiva, SUN Napoli, Ι‑80138 Napoli, Italy, ORL Unit, AORN Cardarelli, Ι‑80131 Naples, Italy, Oncology Unit, ‘San Giovanni di Dio’ Hospital, A.S.L. Napoli 2 Nord, I‑80027 Frattamaggiore (NA), Italy, Radiotherapy Unit, Medicina Futura, Ι‑80035 Acerra, Italy
  • Pages: 467-471
    |
    Published online on: January 27, 2016
       https://doi.org/10.3892/mco.2016.746
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Abstract

Non-melanoma skin cancers (NMSCs) include a heterogeneous group of malignancies arising from the epidermis, comprising squamous cell carcinoma (SCC), basal cell carcinoma (BCC), Merkel cell carcinoma and more rare entities, including malignant pilomatrixoma and sebaceous gland tumours. The treatment of early disease depends primarily on surgery. In addition, certain patients present with extensive local invasion or metastasis, which renders these tumours surgically unresectable. Improving the outcome of radiotherapy through the use of concurrent systemic therapy has been demonstrated in several locally advanced cancer‑treatment paradigms. Recently, agents targeting the human epidermal growth factor receptor (EGFR) have exhibited a consolidated activity in phase II clinical trials and case series reports. Cetuximab is a monoclonal antibody that binds to and completely inhibits the EGFR, which has been revealed to be up‑regulated in a variety of SCCs, including NMSCs. The present review aimed to summarize the role of anti‑EGFR agents in the predominant types of NMSC, including SCC and BCC, and focuses on the cetuximab‑based studies, highlighting the biological rationale of this therapeutic option. In addition, the importance of the association between cetuximab and radiotherapy for locally advanced NMSC is discussed.
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Copy and paste a formatted citation
Spandidos Publications style
Della Vittoria Scarpati G, Perri F, Pisconti S, Costa G, Ricciardiello F, Del Prete S, Napolitano A, Carraturo M, Mazzone S, Addeo R, Addeo R, et al: Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas (Review). Mol Clin Oncol 4: 467-471, 2016.
APA
Della Vittoria Scarpati, G., Perri, F., Pisconti, S., Costa, G., Ricciardiello, F., Del Prete, S. ... Addeo, R. (2016). Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas (Review). Molecular and Clinical Oncology, 4, 467-471. https://doi.org/10.3892/mco.2016.746
MLA
Della Vittoria Scarpati, G., Perri, F., Pisconti, S., Costa, G., Ricciardiello, F., Del Prete, S., Napolitano, A., Carraturo, M., Mazzone, S., Addeo, R."Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas (Review)". Molecular and Clinical Oncology 4.4 (2016): 467-471.
Chicago
Della Vittoria Scarpati, G., Perri, F., Pisconti, S., Costa, G., Ricciardiello, F., Del Prete, S., Napolitano, A., Carraturo, M., Mazzone, S., Addeo, R."Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas (Review)". Molecular and Clinical Oncology 4, no. 4 (2016): 467-471. https://doi.org/10.3892/mco.2016.746
Copy and paste a formatted citation
x
Spandidos Publications style
Della Vittoria Scarpati G, Perri F, Pisconti S, Costa G, Ricciardiello F, Del Prete S, Napolitano A, Carraturo M, Mazzone S, Addeo R, Addeo R, et al: Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas (Review). Mol Clin Oncol 4: 467-471, 2016.
APA
Della Vittoria Scarpati, G., Perri, F., Pisconti, S., Costa, G., Ricciardiello, F., Del Prete, S. ... Addeo, R. (2016). Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas (Review). Molecular and Clinical Oncology, 4, 467-471. https://doi.org/10.3892/mco.2016.746
MLA
Della Vittoria Scarpati, G., Perri, F., Pisconti, S., Costa, G., Ricciardiello, F., Del Prete, S., Napolitano, A., Carraturo, M., Mazzone, S., Addeo, R."Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas (Review)". Molecular and Clinical Oncology 4.4 (2016): 467-471.
Chicago
Della Vittoria Scarpati, G., Perri, F., Pisconti, S., Costa, G., Ricciardiello, F., Del Prete, S., Napolitano, A., Carraturo, M., Mazzone, S., Addeo, R."Concomitant cetuximab and radiation therapy: A possible promising strategy for locally advanced inoperable non-melanoma skin carcinomas (Review)". Molecular and Clinical Oncology 4, no. 4 (2016): 467-471. https://doi.org/10.3892/mco.2016.746
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