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Diagnostic value of dynamic contrast‑enhanced magnetic resonance imaging in rectal cancer and its correlation with tumor differentiation

  • Authors:
    • Fu Shen
    • Jianping Lu
    • Luguang Chen
    • Zhen Wang
    • Yukun Chen

  • View Affiliations

  • Published online on: February 3, 2016     https://doi.org/10.3892/mco.2016.762
  • Pages: 500-506
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Abstract

Dynamic contrast‑enhanced magnetic resonance imaging (DCE‑MRI) is a novel imaging modality that can be used to reflect the microcirculation, although its value in diagnosing rectal cancer is unknown. The present study aimed to explore the clinical application of DCE‑MRI in the preoperative diagnosis of rectal cancer, and its correlation with tumor differentiation. To achieve this, 40 pathologically confirmed patients with rectal cancer and 15 controls were scanned using DCE‑MRI. The Tofts model was applied to obtain the perfusion parameters, including the plasma to extravascular volume transfer (Ktrans), the extravascular to plasma volume transfer (Kep), the extravascular fluid volume (Ve) and the initial area under the enhancement curve (iAUC). Receiver‑operating characteristic (ROC) curves were plotted to determine the diagnostic value. The results demonstrated that the time‑signal intensity curve of the rectal cancer lesion exhibited an outflow pattern. The Ktrans, Kep, Ve, and iAUC values were higher in the cancer patients compared with controls (P<0.05). The intraclass correlation coefficients of Ktrans, Kep, Ve and iAUC, as measured by two independent radiologists, were 0.991, 0.988, 0.972 and 0.984, respectively (all P<0.001), indicating a good consistency. The areas under the ROC curves for Ktrans and iAUC were both >0.9, resulting in a sensitivity and specificity of 100% and 93.3% for Ktrans, and of 92.5%, and 93.3% or 100%, for iAUC, respectively. In the 40 rectal cancer cases, there was a moderate correlation between Ktrans and iAUC, and pathological differentiation (0.3
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April-2016
Volume 4 Issue 4

Print ISSN: 2049-9450
Online ISSN:2049-9469

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  • Impact Factor: 1.2
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  • CiteScore: 2.6
  • CiteScore Rank: Q3: #242/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.693
  • SCImago Journal Rank (SJR): 0.393
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Spandidos Publications style
Shen F, Lu J, Chen L, Wang Z and Chen Y: Diagnostic value of dynamic contrast‑enhanced magnetic resonance imaging in rectal cancer and its correlation with tumor differentiation. Mol Clin Oncol 4: 500-506, 2016
APA
Shen, F., Lu, J., Chen, L., Wang, Z., & Chen, Y. (2016). Diagnostic value of dynamic contrast‑enhanced magnetic resonance imaging in rectal cancer and its correlation with tumor differentiation. Molecular and Clinical Oncology, 4, 500-506. https://doi.org/10.3892/mco.2016.762
MLA
Shen, F., Lu, J., Chen, L., Wang, Z., Chen, Y."Diagnostic value of dynamic contrast‑enhanced magnetic resonance imaging in rectal cancer and its correlation with tumor differentiation". Molecular and Clinical Oncology 4.4 (2016): 500-506.
Chicago
Shen, F., Lu, J., Chen, L., Wang, Z., Chen, Y."Diagnostic value of dynamic contrast‑enhanced magnetic resonance imaging in rectal cancer and its correlation with tumor differentiation". Molecular and Clinical Oncology 4, no. 4 (2016): 500-506. https://doi.org/10.3892/mco.2016.762