Primary mucinous adenocarcinoma of the vulva: A case report and review of the literature

Sui,Yanxia; Zou,Junkai; Batchu,Nasra; Lv,Shulan; Sun,Chao; Du,Jiang; Wang,Qing; Song,Qing; Li,Qiling

doi:10.3892/mco.2016.766

April-2016 Volume 4 Issue 4

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

April-2016 Volume 4 Issue 4

Full Size Image

Case Report

Primary mucinous adenocarcinoma of the vulva: A case report and review of the literature

Authors:
- Yanxia Sui
- Junkai Zou
- Nasra Batchu
- Shulan Lv
- Chao Sun
- Jiang Du
- Qing Wang
- Qing Song
- Qiling Li
View Affiliations / Copyright

Affiliations: Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
Pages: 545-548
|
Published online on: February 4, 2016

https://doi.org/10.3892/mco.2016.766
Expand metrics +

Abstract

Primary vulvar cancer is a rare disease with an incidence of 2‑3 per 100,000 women. The vast majority of vulvar carcinomas are of the squamous cell type (90%). Primary vulvar adenocarcinomas rank among the rare gynecological malignancies. We herein present a case of a vulvar mass near the vaginal orifice, the biopsy of which revealed a mucinous adenocarcinoma. Local excision was performed, followed by postoperative chemotherapy. The patient was asymptomatic and developed no recurrence during the 2 years of follow‑up after surgery and chemotherapy. We consider local excision, with or without chemotherapy, to be an effective therapeutic approach to this type of tumor. However, further studies are required to support our conclusions for early‑stage vulvar mucinous adenocarcinoma.

View Figures

View References

1	Woelber L, Kock L, Gieseking F, Petersen C, Trillsch F, Choschzick M, Jaenicke F and Mahner S: Clinical management of primary vulvar cancer. Eur J Cancer. 47:2315–2321. 2011. View Article : Google Scholar : PubMed/NCBI
2	Kajal B, Talati H, Daya D and Alowami S: Apocrine adenocarcinoma of the vulva. Rare Tumors. 5:e402013. View Article : Google Scholar : PubMed/NCBI
3	Bogani G, Uccella S, Cromi A, Casarin J, Donadello N and Ghezzi F: Primary mammary-like ductal carcinoma of the vulva: A case report and analysis of the literature. Am J Dermatopathol. 35:685–687. 2013. View Article : Google Scholar : PubMed/NCBI
4	Ghamande SA, Kasznica J, Griffiths CT, Finkler NJ and Hamid AM: Mucinous adenocarcinomas of the vulva. Gynecol Oncol. 57:117–120. 1995. View Article : Google Scholar : PubMed/NCBI
5	Cormio G, Carriero C, Loizzi V, Gissi F, Leone L, Putignano G, Resta L and Selvaggi L: ‘Intestinal-type’ mucinous adenocarcinoma of the vulva: A report of two cases. Eur J Gynaecol Oncol. 33:433–435. 2012.PubMed/NCBI
6	Geisler JP, Manahan KJ and Buller RE: Neoadjuvant chemotherapy in vulvar cancer: Avoiding primary exenteration. Gynecol Oncol. 100:53–57. 2006. View Article : Google Scholar : PubMed/NCBI
7	Mendoza S and Helwig EB: Mucinous (adenocystic) carcinoma of the skin. Arch Dermatol. 103:68–78. 1971. View Article : Google Scholar : PubMed/NCBI
8	Rahilly MA, Beattie GJ and Lessells AM: Mucinous eccrine carcinoma of the vulva with neuroendocrine differentiation. Histopathology. 27:82–86. 1995. View Article : Google Scholar : PubMed/NCBI
9	Graf AH, Su HC, Tubbs RR, Hacker GW, Dietz O and Staudach A: Primary neuroendocrine differentiated mucinous adenocarcinoma of the vulva: case report and review of the literature. Anticancer Res. 18:2041–2045. 1998.PubMed/NCBI
10	Magrina JF, Gonzalez-Bosquet J, Weaver AL, Gaffey TA, Webb MJ, Podratz KC and Cornella JL: Primary squamous cell cancer of the vulva: Radical versus modified radical vulvar surgery. Gynecol Oncol. 71:116–121. 1998. View Article : Google Scholar : PubMed/NCBI
11	Woelber L, Trillsch F, Kock L, Grimm D, Petersen C, Choschzick M, Jaenicke F and Mahner S: Management of patients with vulvar cancer: A perspective review according to tumour stage. Ther Adv Med Oncol. 5:183–192. 2013. View Article : Google Scholar : PubMed/NCBI
12	Dittmer C, Fischer D, Diedrich K and Thill M: Diagnosis and treatment options of vulvar cancer: A review. Arch Gynecol Obstet. 285:183–193. 2012. View Article : Google Scholar : PubMed/NCBI
13	Woelber L, Mahner S, Voelker K, Eulenburg CZ, Gieseking F, Choschzick M, Jaenicke F and Schwarz J: Clinicopathological prognostic factors and patterns of recurrence in vulvar cancer. Anticancer Res. 29:545–552. 2009.PubMed/NCBI
14	Domingues AP, Mota F, Durão M, Frutuoso C, Amaral N and de Oliveira CF: Neoadjuvant chemotherapy in advanced vulvar cancer. Int J Gynecol Cancer. 20:294–298. 2010. View Article : Google Scholar : PubMed/NCBI
15	Stehman FB and Look KY: Carcinoma of the vulva. Obstet Gynecol. 107:719–733. 2006. View Article : Google Scholar : PubMed/NCBI
16	Herr D, Juhasz-Boess I and Solomayer EF: Therapy for primary vulvar carcinoma. Geburtshilfe Frauenheilkd. 74:271–275. 2014. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Primary mucinous adenocarcinoma of the vulva: A case report and review of the literature

This article is mentioned in:

Abstract

Figure 1

Related Articles