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Article

CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta‑analysis

  • Authors:
    • Shang Xie
    • Chongdai Luo
    • Xiaofeng Shan
    • Shushan Zhao
    • Jing He
    • Zhigang Cai
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing 100081, P.R. China, Guanghua School and Hospital of Stomatology, Sun Yat‑Sen University, Guangzhou, Guangdong 510055, P.R. China, Department of Orthopaedic Surgery, Xiangya Hospital, Changsha, Hunan 410008, P.R. China, State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Sun Yat‑Sen University Cancer Center, Guangzhou, Guangdong 510060, P.R. China
  • Pages: 660-666
    |
    Published online on: February 5, 2016
       https://doi.org/10.3892/mco.2016.768
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Abstract

Numerous case‑control studies have investigated whether the CYP1A1 gene polymorphism is involved in the occurrence of oral squamous cell carcinoma (OSCC); however, the conclusions are inconsistent. In order to further explore the correlation and obtain a strong conclusion, a meta‑analysis was performed to systematically assess the association between the CYP1A1 MspI polymorphism and risk of OSCC. In the present meta‑analysis, the odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were used to assess the association. The statistical analyses were performed with STATA 11.0 software. The heterogeneity was assessed by Q test and I2 test. The final analysis included 10 studies of 1,505 cases and 1,967 controls. The overall results suggested that the CYP1A1 MspI polymorphism was significantly associated with an increased risk of OSCC (CC+TC vs. TT: OR, 1.31; 95% CI, 1.01‑1.70; P=0.043; CC vs. TC+TT: OR, 2.38; 95% CI, 1.58‑3.58; P<0.001; CC vs. TT: OR, 2.52; 95% CI, 1.60‑3.96; P<0.001; and C vs. T: OR, 1.45; 95% CI, 1.15‑1.83; P<0.001). In a stratified analysis by ethnicity, a statistically significant correlation existed in the Asian population, but not mixed‑race and Caucasian populations. In conclusion, despite several limitations, the present meta‑analysis established that the CYP1A1 MspI polymorphism may be a risk factor for OSCC, particularly among the Asian population.
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Xie S, Luo C, Shan X, Zhao S, He J and Cai Z: CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta‑analysis. Mol Clin Oncol 4: 660-666, 2016.
APA
Xie, S., Luo, C., Shan, X., Zhao, S., He, J., & Cai, Z. (2016). CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta‑analysis. Molecular and Clinical Oncology, 4, 660-666. https://doi.org/10.3892/mco.2016.768
MLA
Xie, S., Luo, C., Shan, X., Zhao, S., He, J., Cai, Z."CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta‑analysis". Molecular and Clinical Oncology 4.4 (2016): 660-666.
Chicago
Xie, S., Luo, C., Shan, X., Zhao, S., He, J., Cai, Z."CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta‑analysis". Molecular and Clinical Oncology 4, no. 4 (2016): 660-666. https://doi.org/10.3892/mco.2016.768
Copy and paste a formatted citation
x
Spandidos Publications style
Xie S, Luo C, Shan X, Zhao S, He J and Cai Z: CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta‑analysis. Mol Clin Oncol 4: 660-666, 2016.
APA
Xie, S., Luo, C., Shan, X., Zhao, S., He, J., & Cai, Z. (2016). CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta‑analysis. Molecular and Clinical Oncology, 4, 660-666. https://doi.org/10.3892/mco.2016.768
MLA
Xie, S., Luo, C., Shan, X., Zhao, S., He, J., Cai, Z."CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta‑analysis". Molecular and Clinical Oncology 4.4 (2016): 660-666.
Chicago
Xie, S., Luo, C., Shan, X., Zhao, S., He, J., Cai, Z."CYP1A1 MspI polymorphism and the risk of oral squamous cell carcinoma: Evidence from a meta‑analysis". Molecular and Clinical Oncology 4, no. 4 (2016): 660-666. https://doi.org/10.3892/mco.2016.768
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