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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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Case Report Open Access

Brain metastases management paradigm shift: A case report and review of the literature

  • Authors:
    • Tamer Refaat
    • Sean Sachdev
    • Brijal Desai
    • Ian Bacchus
    • Saleh Hatoum
    • Plato Lee
    • Orin Bloch
    • James P. Chandler
    • John Kalapurakal
    • Maryanne Hoffman Marymont
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 606611, USA, Department of Neurological Surgery, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 606611, USA
    Copyright: © Refaat et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 487-491
    |
    Published online on: February 8, 2016
       https://doi.org/10.3892/mco.2016.772
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Abstract

Brain metastases are the most common intracranial tumors in adults, accounting for over half of all lesions. Whole‑brain radiation therapy (WBRT) has been a cornerstone in the management of brain metastases for decades. Recently, stereotactic radiosurgery (SRS) has been considered as a definitive or postoperative approach instead of WBRT, to minimize the risk of cognitive impairment that may be associated with WBRT. This is the case report of a 74‑year‑old female patient who was diagnosed with lung cancer in November, 2002, and histopathologically confirmed brain metastases in January, 2005. The patient received 5 treatments with Gamma Knife SRS for recurring brain metastases between 2005 and 2014. The patient remains highly functional, with stable intracranial disease at 10 years since first developing brain metastases, and with stable lung disease. Therefore, Gamma Knife SRS is a safe and effective treatment modality for patients with recurrent intracranial metastases, with durable local control and minimal cognitive impairment.
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1 

Wen PY and Loeffler JS: Management of brain metastases. Oncology (Williston Park). 13:941–954, 957-61; discussion 961–962. 1999.PubMed/NCBI

2 

Johnson JD and Young B: Demographics of brain metastasis. Neurosurg Clin N Am. 7:337–344. 1996.PubMed/NCBI

3 

Borgelt B, Gelber R, Kramer S, Brady LW, Chang CH, Davis LW, Perez CA and Hendrickson FR: The palliation of brain metastases: Final results of the first two studies by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 6:1–9. 1980. View Article : Google Scholar : PubMed/NCBI

4 

Kurtz JM, Gelber R, Brady LW, Carella RJ and Cooper JS: The palliation of brain metastases in a favorable patient population: A randomized clinical trial by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 7:891–895. 1981. View Article : Google Scholar : PubMed/NCBI

5 

Gelber RD, Larson M, Borgelt BB and Kramer S: Equivalence of radiation schedules for the palliative treatment of brain metastases in patients with favorable prognosis. Cancer. 48:1749–1753. 1981. View Article : Google Scholar : PubMed/NCBI

6 

Borgelt B, Gelber R, Larson M, Hendrickson F, Griffin T and Roth R: Ultra-rapid high dose irradiation schedules for the palliation of brain metastases: Final results of the first two studies by the Radiation Therapy Oncology Group. Int J Radiat Oncol Biol Phys. 7:1633–1638. 1981. View Article : Google Scholar : PubMed/NCBI

7 

Sawaya R, Hammoud M, Schoppa D, Hess KR, Wu SZ, Shi WM and Wildrick DM: Neurosurgical outcomes in a modern series of 400 craniotomies for treatment of parenchymal tumors. Neurosurgery. 42:1044–55; discussion 1055–1056. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Asher AL, Burri SH, Wiggins WF, Kelly RP, Boltes MO, Mehrlich M, Norton HJ and Fraser RW: A new treatment paradigm: Neoadjuvant radiosurgery before surgical resection of brain metastases with analysis of local tumor recurrence. Int J Radiat Oncol Biol Phys. 88:899–906. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Barnholtz-Sloan JS, Sloan AE, Davis FG, Vigneau FD, Lai P and Sawaya RE: Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol. 22:2865–2872. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Schouten LJ, Rutten J, Huveneers HA and Twijnstra A: Incidence of brain metastases in a cohort of patients with carcinoma of the breast, colon, kidney and lung and melanoma. Cancer. 94:2698–2705. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Gaspar L, Scott C, Rotman M, Asbell S, Phillips T, Wasserman T, McKenna WG and Byhardt R: Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Int J Radiat Oncol Biol Phys. 37:745–751. 1997. View Article : Google Scholar : PubMed/NCBI

12 

Sperduto PW, Chao ST, Sneed PK, Luo X, Suh J, Roberge D, Bhatt A, Jensen AW, Brown PD, Shih H, et al: Diagnosis-specific prognostic factors, indexes and treatment outcomes for patients with newly diagnosed brain metastases: A multi-institutional analysis of 4,259 patients. Int J Radiat Oncol Biol Phys. 77:655–661. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Patchell RA, Tibbs PA, Walsh JW, Dempsey RJ, Maruyama Y, Kryscio RJ, Markesbery WR, Macdonald JS and Young B: A randomized trial of surgery in the treatment of single metastases to the brain. N Engl J Med. 322:494–500. 1990. View Article : Google Scholar : PubMed/NCBI

14 

Noordijk EM, Vecht CJ, Haaxma-Reiche H, Padberg GW, Voormolen JH, Hoekstra FH, Tans JT, Lambooij N, Metsaars JA and Wattendorff AR: The choice of treatment of single brain metastasis should be based on extracranial tumor activity and age. Int J Radiat Oncol Biol Phys. 29:711–717. 1994. View Article : Google Scholar : PubMed/NCBI

15 

Schwartz M: Stereotactic radiosurgery: Comparing different technologies. CMAJ. 158:625–178. 1998.PubMed/NCBI

16 

Kuo JS, Yu C, Petrovich Z and Apuzzo ML: The CyberKnife stereotactic radiosurgery system: Description, installation and an initial evaluation of use and functionality. Neurosurgery. 53:1235–1239; discussion 1239. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Miller DW: A review of proton beam radiation therapy. Med Phys. 22:1943–1954. 1995. View Article : Google Scholar : PubMed/NCBI

18 

Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, Werner-Wasik M, Demas W, Ryu J, Bahary JP, et al: Whole-brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: Phase III results of the RTOG 9508 randomised trial. Lancet. 363:1665–1672. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Pirzkall A, Debus J, Lohr F, Fuss M, Rhein B, Engenhart-Cabillic R and Wannenmacher M: Radiosurgery alone or in combination with whole-brain radiotherapy for brain metastases. J Clin Oncol. 16:3563–3569. 1998.PubMed/NCBI

20 

Alexander E III, Moriarty TM and Loeffler JS: Radiosurgery for metastases. J Neurooncol. 27:279–285. 1996. View Article : Google Scholar : PubMed/NCBI

21 

Alexander E III, Moriarty TM, Davis RB, Wen PY, Fine HA, Black PM, Kooy HM and Loeffler JS: Stereotactic radiosurgery for the definitive, noninvasive treatment of brain metastases. J Natl Cancer Inst. 87:34–40. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Flickinger JC, Kondziolka D, Lunsford LD, Coffey RJ, Goodman ML, Shaw EG, Hudgins WR, Weiner R, Harsh GR IV and Sneed PK: A multi-institutional experience with stereotactic radiosurgery for solitary brain metastasis. Int J Radiat Oncol Biol Phys. 28:797–802. 1994. View Article : Google Scholar : PubMed/NCBI

23 

Yamamoto M, Serizawa T, Shuto T, Akabane A, Higuchi Y, Kawagishi J, Yamanaka K, Sato Y, Jokura H, Yomo S, et al: Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): A multi-institutional prospective observational study. Lancet Oncol. 15:387–395. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Kocher M, Soffietti R, Abacioglu U, Villà S, Fauchon F, Baumert BG, Fariselli L, Tzuk-Shina T, Kortmann RD, Carrie C, et al: Adjuvant whole-brain radiotherapy versus observation after radiosurgery or surgical resection of one to three cerebral metastases: Results of the EORTC 22952–26001 study. J Clin Oncol. 29:134–141. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Refaat T, Sachdev S, Desai B, Bacchus I, Hatoum S, Lee P, Bloch O, Chandler JP, Kalapurakal J, Marymont MH, Marymont MH, et al: Brain metastases management paradigm shift: A case report and review of the literature. Mol Clin Oncol 4: 487-491, 2016.
APA
Refaat, T., Sachdev, S., Desai, B., Bacchus, I., Hatoum, S., Lee, P. ... Marymont, M.H. (2016). Brain metastases management paradigm shift: A case report and review of the literature. Molecular and Clinical Oncology, 4, 487-491. https://doi.org/10.3892/mco.2016.772
MLA
Refaat, T., Sachdev, S., Desai, B., Bacchus, I., Hatoum, S., Lee, P., Bloch, O., Chandler, J. P., Kalapurakal, J., Marymont, M. H."Brain metastases management paradigm shift: A case report and review of the literature". Molecular and Clinical Oncology 4.4 (2016): 487-491.
Chicago
Refaat, T., Sachdev, S., Desai, B., Bacchus, I., Hatoum, S., Lee, P., Bloch, O., Chandler, J. P., Kalapurakal, J., Marymont, M. H."Brain metastases management paradigm shift: A case report and review of the literature". Molecular and Clinical Oncology 4, no. 4 (2016): 487-491. https://doi.org/10.3892/mco.2016.772
Copy and paste a formatted citation
x
Spandidos Publications style
Refaat T, Sachdev S, Desai B, Bacchus I, Hatoum S, Lee P, Bloch O, Chandler JP, Kalapurakal J, Marymont MH, Marymont MH, et al: Brain metastases management paradigm shift: A case report and review of the literature. Mol Clin Oncol 4: 487-491, 2016.
APA
Refaat, T., Sachdev, S., Desai, B., Bacchus, I., Hatoum, S., Lee, P. ... Marymont, M.H. (2016). Brain metastases management paradigm shift: A case report and review of the literature. Molecular and Clinical Oncology, 4, 487-491. https://doi.org/10.3892/mco.2016.772
MLA
Refaat, T., Sachdev, S., Desai, B., Bacchus, I., Hatoum, S., Lee, P., Bloch, O., Chandler, J. P., Kalapurakal, J., Marymont, M. H."Brain metastases management paradigm shift: A case report and review of the literature". Molecular and Clinical Oncology 4.4 (2016): 487-491.
Chicago
Refaat, T., Sachdev, S., Desai, B., Bacchus, I., Hatoum, S., Lee, P., Bloch, O., Chandler, J. P., Kalapurakal, J., Marymont, M. H."Brain metastases management paradigm shift: A case report and review of the literature". Molecular and Clinical Oncology 4, no. 4 (2016): 487-491. https://doi.org/10.3892/mco.2016.772
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