Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
May-2016 Volume 4 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2016 Volume 4 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Surgical treatment of the primary tumour improves the overall survival in patients with metastatic breast cancer: A systematic review and meta‑analysis

  • Authors:
    • Hannah Headon
    • Umar Wazir
    • Abdul Kasem
    • Kefah Mokbel
  • View Affiliations / Copyright

    Affiliations: The London Breast Institute, Princess Grace Hospital, London W1U 5NY, UK
  • Pages: 863-867
    |
    Published online on: February 16, 2016
       https://doi.org/10.3892/mco.2016.778
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Traditionally, stage IV metastatic breast cancer has been treated with systemic therapy and/or radiotherapy in order to decrease cancer‑associated symptoms, maintain quality of life and control disease burden. Previous research suggests that surgical treatment of the primary tumour may prolong survival, as well achieve local control of disease. Using the PubMed and Ovid SP databases, a literature review and meta‑analysis was performed in order to assess whether surgical resection of the primary tumour in metastatic breast cancer prolongs survival. In this meta‑analysis, a pooled hazard ratio of 0.63 (95% confidence interval, 0.58‑0.7; P<0.0001) was revealed, equating to a 37% reduction in risk of mortality in patients that underwent surgical resection of the primary tumour. Therefore, it was concluded that surgery of the primary tumour in stage IV breast cancer appears to offer a survival benefit in metastatic patients.
View Figures

Figure 1

Figure 2

View References

1 

Petrelli F and Barni S: Surgery of primary tumors in stage IV breast cancer: An updated meta-analysis of published studies with meta-regression. Med Oncol. 29:3282–3290. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Ruiterkamp J, Voogd AC, Bosscha K, Tjan-Heijnen VC and Ernst MF: Impact of breast surgery on survival in patients with distant metastases at initial presentation: A systematic review of the literature. Breast Cancer Res Treat. 120:9–16. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Akay CL, Ueno NT, Chisholm GB, Hortobagyi GN, Woodward WA, Alvarez RH, Bedrosian I, Kuerer HM, Hunt KK, Huo L and Babiera GV: Primary tumor resection as a component of multimodality treatment may improve local control and survival in patients with stage IV inflammatory breast cancer. Cancer. 120:1319–1328. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Babiera GV, Rao R, Feng L, Meric-Bernstam F, Kuerer HM, Singletary SE, Hunt KK, Ross MI, Gwyn KM, Feig BW, et al: Effect of primary tumor extirpation in breast cancer patients who present with stage IV disease and an intact primary tumor. Ann Surg Oncol. 13:776–782. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Budd GT, Cristofanilli M, Ellis MJ, Stopeck A, Borden E, Miller MC, Matera J, Repollet M, Doyle GV, Terstappen LW and Hayes DF: Circulating tumor cells versus imaging-predicting overall survival in metastatic breast cancer. Clin Cancer Res. 12:6403–6409. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Kim MY, Oskarsson T, Acharyya S, Nguyen DX, Zhang XH, Norton L and Massagué J: Tumor self-seeding by circulating cancer cells. Cell. 139:1315–1326. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Chiotaki R, Polioudaki H and Theodoropoulos PA: Cancer stem cells in solid and liquid tissues of breast cancer patients: Characterization and therapeutic perspectives. Curr Cancer Drug Targets. 15:256–269. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Bafford AC, Burstein HJ, Barkley CR, Smith BL, Lipsitz S, Iglehart JD, Winer EP and Golshan M: Breast surgery in stage IV breast cancer: Impact of staging and patient selection on overall survival. Breast Cancer Res Treat. 115:7–12. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Blanchard DK, Shetty PB, Hilsenbeck SG and Elledge RM: Association of surgery with improved survival in stage IV breast cancer patients. Ann Surg. 247:732–738. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Dominici L, Najita J, Hughes M, Niland J, Marcom P, Wong YN, Carter B, Javid S, Edge S, Burstein H and Golshan M: Surgery of the primary tumor does not improve survival in stage IV breast cancer. Breast Cancer Res Treat. 129:459–465. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Fields RC, Jeffe DB, Trinkaus K, Zhang Q, Arthur C, Aft R, Dietz JR, Eberlein TJ, Gillanders WE and Margenthaler JA: Surgical resection of the primary tumor is associated with increased long-term survival in patients with stage IV breast cancer after controlling for site of metastasis. Ann Surg Oncol. 14:3345–3351. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Gnerlich J, Jeffe DB, Deshpande AD, Beers C, Zander C and Margenthaler JA: Surgical removal of the primary tumor increases overall survival in patients with metastatic breast cancer: Analysis of the 1988–2003 SEER data. Ann Surg Oncol. 14:2187–2194. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Hazard HW, Gorla SR, Scholtens D, Kiel K, Gradishar WJ and Khan SA: Surgical resection of the primary tumor, chest wall control and survival in women with metastatic breast cancer. Cancer. 113:2011–2019. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Khan SA, Stewart AK and Morrow M: Does aggressive local therapy improve survival in metastatic breast cancer? Surgery. 132:620–626; discussion 626–627. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Lang JE, Tereffe W, Mitchell MP, Rao R, Feng L, Meric-Bernstam F, Bedrosian I, Kuerer HM, Hunt KK, Hortobagyi GN and Babiera GV: Primary tumor extirpation in breast cancer patients who present with stage IV disease is associated with improved survival. Ann Surg Oncol. 20:1893–1899. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Neuman HB, Morrogh M, Gonen M, Van Zee KJ, Morrow M and King TA: Stage IV breast cancer in the era of targeted therapy: Does surgery of the primary tumor matter? Cancer. 116:1226–1233. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Pathy NB, Verkooijen HM, Taib NA, Hartman M and Yip CH: Impact of breast surgery on survival in women presenting with metastatic breast cancer. Br J Surg. 98:1566–1572. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Pérez-Fidalgo JA, Pimentel P, Caballero A, Bermejo B, Barrera JA, Burgues O, Martinez-Ruiz F, Chirivella I, Bosch A, Martínez-Agulló A and Lluch A: Removal of primary tumor improves survival in metastatic breast cancer. Does timing of surgery influence outcomes? Breast. 20:548–554. 2011.PubMed/NCBI

19 

Rapiti E, Verkooijen HM, Vlastos G, Fioretta G, Neyroud-Caspar I, Sappino AP, Chappuis PO and Bouchardy C: Complete excision of primary breast tumor improves survival of patients with metastatic breast cancer at diagnosis. J Clin Oncol. 24:2743–2749. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Rashaan ZM, Bastiaannet E, Portielje JE, van de Water W, van der Velde S, Ernst MF, van de Velde CJ and Liefers GJ: Surgery in metastatic breast cancer: Patients with a favorable profile seem to have the most benefit from surgery. Eur J Surg Oncol. 38:52–56. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Kakarala M and Wicha MS: Implications of the cancer stem-cell hypothesis for breast cancer prevention and therapy. J Clin Oncol. 26:2813–2820. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Danna EA, Sinha P, Gilbert M, Clements VK, Pulaski BA and Ostrand-Rosenberg S: Surgical removal of primary tumor reverses tumor-induced immunosuppression despite the presence of metastatic disease. Cancer Res. 64:2205–2211. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Shien T, Kinoshita T, Shimizu C, Hojo T, Taira N, Doihara H and Akashi-Tanaka S: Primary tumor resection improves the survival of younger patients with metastatic breast cancer. Oncol Rep. 21:827–832. 2009.PubMed/NCBI

24 

Ruiterkamp J, Voogd AC, Tjan-Heijnen VC, Bosscha K, van der Linden YM, Rutgers EJ, Boven E, van der Sangen MJ and Ernst MF: Dutch Breast Cancer Trialists' Group (BOOG): SUBMIT: Systemic therapy with or without up front surgery of the primary tumor in breast cancer patients with distant metastases at initial presentation. BMC Surg. 12:52012. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Headon H, Wazir U, Kasem A and Mokbel K: Surgical treatment of the primary tumour improves the overall survival in patients with metastatic breast cancer: A systematic review and meta‑analysis. Mol Clin Oncol 4: 863-867, 2016.
APA
Headon, H., Wazir, U., Kasem, A., & Mokbel, K. (2016). Surgical treatment of the primary tumour improves the overall survival in patients with metastatic breast cancer: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 4, 863-867. https://doi.org/10.3892/mco.2016.778
MLA
Headon, H., Wazir, U., Kasem, A., Mokbel, K."Surgical treatment of the primary tumour improves the overall survival in patients with metastatic breast cancer: A systematic review and meta‑analysis". Molecular and Clinical Oncology 4.5 (2016): 863-867.
Chicago
Headon, H., Wazir, U., Kasem, A., Mokbel, K."Surgical treatment of the primary tumour improves the overall survival in patients with metastatic breast cancer: A systematic review and meta‑analysis". Molecular and Clinical Oncology 4, no. 5 (2016): 863-867. https://doi.org/10.3892/mco.2016.778
Copy and paste a formatted citation
x
Spandidos Publications style
Headon H, Wazir U, Kasem A and Mokbel K: Surgical treatment of the primary tumour improves the overall survival in patients with metastatic breast cancer: A systematic review and meta‑analysis. Mol Clin Oncol 4: 863-867, 2016.
APA
Headon, H., Wazir, U., Kasem, A., & Mokbel, K. (2016). Surgical treatment of the primary tumour improves the overall survival in patients with metastatic breast cancer: A systematic review and meta‑analysis. Molecular and Clinical Oncology, 4, 863-867. https://doi.org/10.3892/mco.2016.778
MLA
Headon, H., Wazir, U., Kasem, A., Mokbel, K."Surgical treatment of the primary tumour improves the overall survival in patients with metastatic breast cancer: A systematic review and meta‑analysis". Molecular and Clinical Oncology 4.5 (2016): 863-867.
Chicago
Headon, H., Wazir, U., Kasem, A., Mokbel, K."Surgical treatment of the primary tumour improves the overall survival in patients with metastatic breast cancer: A systematic review and meta‑analysis". Molecular and Clinical Oncology 4, no. 5 (2016): 863-867. https://doi.org/10.3892/mco.2016.778
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team