Radiation-induced optic neuropathy following external beam radiation therapy for nasopharyngeal carcinoma: A retrospective case-control study

Wang,Wei; Yang,Hui; Guo,Ling; Su,Hongyu; Wei,Shihui; Zhang,Xiulan

doi:10.3892/mco.2016.787

May-2016 Volume 4 Issue 5

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May-2016 Volume 4 Issue 5

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Article

Radiation-induced optic neuropathy following external beam radiation therapy for nasopharyngeal carcinoma: A retrospective case-control study

Authors:
- Wei Wang
- Hui Yang
- Ling Guo
- Hongyu Su
- Shihui Wei
- Xiulan Zhang
View Affiliations / Copyright

Affiliations: Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China, Sun Yat‑sen University Cancer Center State Key Laboratory of Oncology in South China, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China, Department of Ophthalmology, General Hospital of the People's Liberation Army, Beijing 100000, P.R. China
Pages: 868-872
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Published online on: February 22, 2016

https://doi.org/10.3892/mco.2016.787
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Abstract

Radiation-induced optic neuropathy (RION) is a severe ocular complication in patients with nasopharyngeal carcinoma (NPC) following external beam radiation therapy. However, the systemic risk factors for this condition remain unclear. Therefore, patients with NPC who received radiotherapy between 2004 and 2007 at the Sun Yat‑sen University Cancer center were retrospectively reviewed in this case‑control study. The study included 40 RION patients and 40 patients in the control group, who were strictly matched to the RION patients by tumor histopathology, location, Union for International Cancer Control-Tumor Node Metastasis classification and radiotherapy protocol. Univariate and multivariate statistical regression analyses were performed to identify factors predictive of RION. The univariate analysis demonstrated that age (>60 years), gender (female) and chemotherapy significantly affected the risk of RION, whereas diabetes, hypertension and hepatitis B virus infection did not exert a significant effect. The results of the multivariate analysis suggested that only gender and chemotherapy were significantly associated with an increased incidence of RION. Therefore, the results of the present study suggested that female gender and chemotherapy constitute risk factors for the development of RION following radiotherapy for NPC. The ocular symptoms of high‑risk patients should be carefully investigated and reported by ophthalmologists.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Radiation-induced optic neuropathy following external beam radiation therapy for nasopharyngeal carcinoma: A retrospective case-control study

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