Magnetic resonance imaging findings and prognosis of gastric‑type mucinous adenocarcinoma (minimal deviation adenocarcinoma or adenoma malignum) of the uterine corpus: Two case reports

Hino,Mayo; Yamaguchi,Ken; Abiko,Kaoru; Yoshioka,Yumiko; Hamanishi,Junzo; Kondoh,Eiji; Koshiyama,Masafumi; Baba,Tsukasa; Matsumura,Noriomi; Minamiguchi,Sachiko; Kido,Aki; Konishi,Ikuo

doi:10.3892/mco.2016.789

May-2016 Volume 4 Issue 5

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May-2016 Volume 4 Issue 5

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Case Report

Magnetic resonance imaging findings and prognosis of gastric‑type mucinous adenocarcinoma (minimal deviation adenocarcinoma or adenoma malignum) of the uterine corpus: Two case reports

Authors:
- Mayo Hino
- Ken Yamaguchi
- Kaoru Abiko
- Yumiko Yoshioka
- Junzo Hamanishi
- Eiji Kondoh
- Masafumi Koshiyama
- Tsukasa Baba
- Noriomi Matsumura
- Sachiko Minamiguchi
- Aki Kido
- Ikuo Konishi
View Affiliations / Copyright

Affiliations: Department of Gynecology and Obstetrics, Kyoto University Hospital, Kyoto, Kyoto 606-8507, Japan, Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Kyoto 606-8507, Japan, Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Hospital, Kyoto, Kyoto 606-8507, Japan
Pages: 699-704
|
Published online on: February 23, 2016

https://doi.org/10.3892/mco.2016.789
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Abstract

Our group previously documented the first, very rare case of primary gastric‑type mucinous adenocarcinoma of the uterine corpus. Although this type of endometrial cancer appears to be similar to the gastric‑type adenocarcinoma of the uterine cervix, its main symptoms, appearance on magnetic resonance imaging (MRI) and prognosis have not been fully elucidated due to its rarity. we herein describe an additional case of gastric‑type mucinous adenocarcinoma of the endometrium and review the relevant literature. The two cases at our institution (Kyoto University Hospital, Kyoto, Japan) involved postmenopausal women with a primary complaint of abnormal genital bleeding. Microscopic examination of the hysterectomy specimens indicated a highly differentiated mucinous adenocarcinoma with a desmoplastic stromal reaction. Immunohistochemistry for HIK1083 and̸or MUC6 was positive in both cases, suggesting a gastric phenotype. Both patients were diagnosed at an advanced stage, they relapsed or recurred immediately after adjuvant chemotherapy, and eventually succumbed to the disease. The main symptom of gastric‑type mucinous adenocarcinoma of the uterine cervix is watery discharge, whereas abnormal genital bleeding in addition to watery discharge is mainly observed in the mucinous type of endometrial adenocarcinoma. Cystic cavities in the tumor are present on MRI in cases of endometrial origin, and prognosis is very poor due to resistance to chemotherapy. Thus, gastric‑type mucinous adenocarcinoma of the uterine endometrium exhibits a clinical behavior that is similar to tumors originating from the uterine cervix, but is associated with distinguishing clinical symptoms. The incidence of gastric‑type endometrial adenocarcinoma may be higher than expected.

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1	Ross JC, Eifel PJ, Cox RS, Kempson RL and Hendrickson MR: Primary mucinous adenocarcinoma of the endometrium. A clinicopathologic and histochemical study. Am J Surg Pathol. 7:715–729. 1983. View Article : Google Scholar : PubMed/NCBI
2	Creasman WT, Morrow CP, Bundy BN, Homesley HD, Graham JE and Heller PB: Surgical pathologic spread patterns of endometrial cancer. A Gynecologic Oncology Group Study. Cancer. 60(Suppl 8): S2035–S2041. 1987. View Article : Google Scholar
3	Abiko K, Baba T, Ogawa M, Mikami Y, Koyama T, Mandai M and Konishi I: Minimal deviation mucinous adenocarcinoma (‘adenoma malignum’) of the uterine corpus. Pathol Int. 60:42–47. 2010. View Article : Google Scholar : PubMed/NCBI
4	Gotoh T, Hayashi N, Takeda S, Itoyama S, Takano M and Kikuchi Y: Synchronous mucinous adenocarcinoma of the endometrium and mucinous cystadenoma of bilateral ovaries presenting during fertility therapy. Int J Gynecol Cancer. 14:169–171. 2004. View Article : Google Scholar : PubMed/NCBI
5	Mikami Y and McCluggage WG: Endocervical glandular lesions exhibiting gastric differentiation: An emerging spectrum of benign, premalignant and malignant lesions. Adv Anat Pathol. 20:227–237. 2013. View Article : Google Scholar : PubMed/NCBI
6	Kojima A, Mikami Y, Sudo T, Yamaguchi S, Kusanagi Y, Ito M and Nishimura R: Gastric morphology and immunophenotype predict poor outcome in mucinous adenocarcinoma of the uterine cervix. Am J Surg Pathol. 31:664–672. 2007. View Article : Google Scholar : PubMed/NCBI
7	Silverberg SG and Hurt WG: Minimal deviation adenocarcinoma (‘adenoma malignum’) of the cervix: A reappraisal. Am J Obstet Gynecol. 121:971–975. 1975. View Article : Google Scholar : PubMed/NCBI
8	Gilks CB, Young RH, Aguirre P, DeLellis RA and Scully RE: Adenoma malignum (minimal deviation adenocarcinoma) of the uterine cervix. A clinicopathological and immunohistochemical analysis of 26 cases. Am J Surg Pathol. 13:717–729. 1989. View Article : Google Scholar : PubMed/NCBI
9	Kido A, Mikami Y, Koyama T, Kataoka M, Shitano F, Konishi I and Togashi K: Magnetic resonance appearance of gastric-type adenocarcinoma of the uterine cervix in comparison with that of usual-type endocervical adenocarcinoma: A pitfall of newly described unusual subtype of endocervical adenocarcinoma. Int J Gynecol Cancer. 24:1474–1479. 2014. View Article : Google Scholar : PubMed/NCBI
10	Nucci MR, Prasad CJ, Crum CP and Mutter GL: Mucinous endometrial epithelial proliferations: A morphologic spectrum of changes with diverse clinical significance. Mod Pathol. 12:1137–1142. 1999.PubMed/NCBI
11	Fujiwara M and Longacre TA: Low-grade mucinous adenocarcinoma of the uterine corpus: A rare and deceptively bland form of endometrial carcinoma. Am J Surg Pathol. 35:537–544. 2011. View Article : Google Scholar : PubMed/NCBI
12	Plataniotis G and Castiglione M: ESMO Guidelines Working Group: Endometrial cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 21(Suppl 5): v41–v45. 2010. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Magnetic resonance imaging findings and prognosis of gastric‑type mucinous adenocarcinoma (minimal deviation adenocarcinoma or adenoma malignum) of the uterine corpus: Two case reports

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