B3‑lesions of the breast and cancer risk ‑ an analysis of mammography screening patients

Hoffmann,Oliver; Stamatis,Gesina Athina; Bittner,Ann‑Kathrin; Arnold,Georg; Schnabel,Rolf; Krüger,Karlgeorg; Kimmig,Rainer; Heubner,Martin

doi:10.3892/mco.2016.790

B3‑lesions of the breast and cancer risk ‑ an analysis of mammography screening patients

Authors:
- Oliver Hoffmann
- Gesina Athina Stamatis
- Ann‑Kathrin Bittner
- Georg Arnold
- Rolf Schnabel
- Karlgeorg Krüger
- Rainer Kimmig
- Martin Heubner
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Affiliations: Department of Gynecology and Obstetrics, University Hospital Essen, University of Duisburg‑Essen, D‑45122 Essen, Germany, Center of Pathology Essen‑Mitte, D‑45276 Essen, Germany, Department of Pathology Essen-Steele, D‑45276 Essen, Germany, Diavero Breast Diagnosis Center, D‑45257 Essen, Germany
Published online on: February 23, 2016 https://doi.org/10.3892/mco.2016.790
Pages: 705-708

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Abstract

The use of mammography screening, followed by needle core biopsy (NCB), is associated with an increasing amount of invasive procedures. A considerable amount of specimens must be classified as lesions with uncertain malignant potential (B3‑lesion). In these cases, an open biopsy is indicated for further diagnosis. We evaluated patients with B3‑lesions to determine the risk of malignancy corresponding to the histopathological NCB results and the type of radiological lesion identified. A total of 95 patients participating in the German mammography screening program with a B3‑lesion following NCB (104 B3‑lesions in total) were included in our analysis. We analyzed the correlation between the initial histopathological findings from the NCB specimen and cancer risk. We further analyzed the correlations of malignant results with the type of mammographic lesion. In 23 cases (22%), histopathological examination following excision revealed a malignant lesion, including invasive and in situ carcinoma. The positive predictive value of the subgroups of B3‑lesions ranged between 0.11 and 0.31; the B3‑lesion associated with the highest cancer risk was the atypical ductal hyperplasia; however, no significant difference was observed between the B3‑lesion subgroups (P=0.309) regarding the risk of malignancy. Comparing the different types of mammographic findings, such as radiological mass or microcalcifications, there was no significant difference in the risk for malignancy (P=0.379). The different types of B3‑lesions did not exhibit differences in the risk for malignancy, and the morphological type of mammographic lesion does not appear to be correlated with cancer risk; therefore, our results underline the need for open biopsy in patients with B3‑lesions following NCB.

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