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Case Report Open Access

Cutaneous involvement as a rare first sign of systemic mantle cell lymphoma: A case report and review of the literature

  • Authors:
    • Igor Hrgovic
    • Sylvia Hartmann
    • Björn Steffen
    • Thomas Vogl
    • Roland Kaufmann
    • Markus Meissner
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Venereology and Allergology, Johann Wolfgang Goethe University Hospital of Frankfurt, D-60590 Frankfurt am Main, Germany, Institute of Pathology, Johann Wolfgang Goethe University Hospital of Frankfurt, D-60590 Frankfurt am Main, Germany, Division of Hematology/Oncology, Department of Internal Medicine, Johann Wolfgang Goethe University Hospital of Frankfurt, D-60590 Frankfurt am Main, Germany, Institute for Diagnostic and Interventional Radiology, Johann Wolfgang Goethe University Hospital of Frankfurt, D-60590 Frankfurt am Main, Germany
    Copyright: © Hrgovic et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 728-732
    |
    Published online on: February 25, 2016
       https://doi.org/10.3892/mco.2016.792
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Abstract

Mantle cell lymphoma (MCL) is a unique type of B-cell non-Hodgkin's lymphoma, which very rarely exhibits skin involvement. We herein describe the case of a 55-year-old woman, who initially presented with a nodular mass of the right infraorbital region. On histological analysis of the subcutaneous tissue, a diffuse neoplastic cell infiltration was identified, composed of medium‑sized lymphoid cells with irregular nuclei, which was diagnosed as MCL. The tumor cells were positive for CD5, CD20, CD79a, cyclin D1 and sex‑determining region Y-box 11, but negative for CD10 and CD23. Our patient received six cycles of R‑CHOP chemotherapy and intrathecal methotrexate as central nervous system prophylaxis. However, the patient relapsed 1 year later and was treated with two cycles of R‑DHAP and one cycle of intrathecal methotrexate. After achieving partial remission, the patient was consolidated with peripheral blood stem cell transplantation using the BEAM conditioning regime. While prior case studies suggest that skin invasion by MCL is associated with a poor prognosis, our patient remains alive almost 4 years after the initial presentation. Skin involvement as a first sign of systemic MCL is very rare and must be considered.
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Copy and paste a formatted citation
Spandidos Publications style
Hrgovic I, Hartmann S, Steffen B, Vogl T, Kaufmann R and Meissner M: Cutaneous involvement as a rare first sign of systemic mantle cell lymphoma: A case report and review of the literature. Mol Clin Oncol 4: 728-732, 2016.
APA
Hrgovic, I., Hartmann, S., Steffen, B., Vogl, T., Kaufmann, R., & Meissner, M. (2016). Cutaneous involvement as a rare first sign of systemic mantle cell lymphoma: A case report and review of the literature. Molecular and Clinical Oncology, 4, 728-732. https://doi.org/10.3892/mco.2016.792
MLA
Hrgovic, I., Hartmann, S., Steffen, B., Vogl, T., Kaufmann, R., Meissner, M."Cutaneous involvement as a rare first sign of systemic mantle cell lymphoma: A case report and review of the literature". Molecular and Clinical Oncology 4.5 (2016): 728-732.
Chicago
Hrgovic, I., Hartmann, S., Steffen, B., Vogl, T., Kaufmann, R., Meissner, M."Cutaneous involvement as a rare first sign of systemic mantle cell lymphoma: A case report and review of the literature". Molecular and Clinical Oncology 4, no. 5 (2016): 728-732. https://doi.org/10.3892/mco.2016.792
Copy and paste a formatted citation
x
Spandidos Publications style
Hrgovic I, Hartmann S, Steffen B, Vogl T, Kaufmann R and Meissner M: Cutaneous involvement as a rare first sign of systemic mantle cell lymphoma: A case report and review of the literature. Mol Clin Oncol 4: 728-732, 2016.
APA
Hrgovic, I., Hartmann, S., Steffen, B., Vogl, T., Kaufmann, R., & Meissner, M. (2016). Cutaneous involvement as a rare first sign of systemic mantle cell lymphoma: A case report and review of the literature. Molecular and Clinical Oncology, 4, 728-732. https://doi.org/10.3892/mco.2016.792
MLA
Hrgovic, I., Hartmann, S., Steffen, B., Vogl, T., Kaufmann, R., Meissner, M."Cutaneous involvement as a rare first sign of systemic mantle cell lymphoma: A case report and review of the literature". Molecular and Clinical Oncology 4.5 (2016): 728-732.
Chicago
Hrgovic, I., Hartmann, S., Steffen, B., Vogl, T., Kaufmann, R., Meissner, M."Cutaneous involvement as a rare first sign of systemic mantle cell lymphoma: A case report and review of the literature". Molecular and Clinical Oncology 4, no. 5 (2016): 728-732. https://doi.org/10.3892/mco.2016.792
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