synchronous double primary cancer of the lung and nasal vestibule: A case report and literature review

Ji,Huai Jun; Zang,Qi; Wang,Wei; Sun,Ning Bo; Cao,Ming; Zhu,Qiang; Jiang,Zhong Min

doi:10.3892/mco.2016.799

synchronous double primary cancer of the lung and nasal vestibule: A case report and literature review

Authors:
- Huai Jun Ji
- Qi Zang
- Wei Wang
- Ning Bo Sun
- Ming Cao
- Qiang Zhu
- Zhong Min Jiang
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Affiliations: Division of Surgery, Graduate Department, Weifang Medical College, Weifang, Shandong 261031, P.R. China, Department of Thoracic Surgery, Qianfoshan Hospital Affiliated to Shandong University, Jinan, Shandong 250014, P.R. China
Published online on: March 3, 2016 https://doi.org/10.3892/mco.2016.799
Pages: 807-810

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Abstract

Squamous cell carcinoma (SCC) of the nasal vestibule is a rare tumor entity, and its occurrence combined with lung cancer is even rarer. Thus, several patients are often initially misdiagnosed or remain undiagnosed. This is the case report of a 55‑year‑old male patient who presented to our hospital with a neoplasm in the left lung. The patient was treated with left upper pulmonary lobectomy and the subsequent histopathological examination of the surgical specimen revealed a poorly differentiated SCC. On postoperative week 4, the patient presented with purulent and bloody discharge from the left nostril and was misdiagnosed with an upper jaw cyst. After another 3 weeks, the patient was re‑admitted to the hospital with a mass of left nostril and nasal congestion. Tru‑Cut biopsies from the nasal area and histopathological examination revealed a moderately differentiated SCC. According to the clinical presentation and the histopathological findings, the patient was diagnosed with double primary cancer of the lung and the nasal vestibule. The mass of the left nostril was significantly reduced in size with radiotherapy. To the best of our knowledge, there is no similar case previously reported in the literature. Due to the rarity of scc of the nasal vestibule concomittant with lung cancer, we herein present this case report with a review of the relevant literature and investigation of the clinical characteristics.

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1	Moertel CG, Dockerty MB and Baggenstoss AH: Multiple primary malignant neoplasms. II. Tumors of different tissues or organs. Cancer. 14:231–237. 1961. View Article : Google Scholar : PubMed/NCBI
2	Billroth T: General surgical pathology and therapeutics in 51 Vorlesungen: A textbook for students and physicians in fifty-one lectures (14th). Berlin, DE: G. Rerimer. 1889.
3	Warren S and Gates O: Multiple primary malignant tumors: Surgery of literature and statistical study. Am J Cancer. 16:1358–1414. 1932.
4	Tsukuma H, Fujimoto I, Hanai A, Hiyama T, Kitagawa T and Kinoshita N: Incidence of second primary cancers in Osaka residents, Japan, with special reference to cumulative and relative risks. Jpn J Cancer Res. 85:339–345. 1994. View Article : Google Scholar : PubMed/NCBI
5	Jemal A, Bray F, Center M, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI
6	Rossi A, Chiodini P, Sun JM, O'Brien ME, von Plessen C, Barata F, Park K, Popat S, Bergman B, Parente B, et al: Six versus fewer planned cycles of first-line platinum-based chemotherapy for non-small-cell lung cancer: A systematic review and meta-analysis of individual patient data. Lancet Oncol. 15:1254–1262. 2014. View Article : Google Scholar : PubMed/NCBI
7	Thanendrarajan S, Nowak M, Abken H and Schmidt-Wolf IG: Combining cytokine-induced killer cells with vaccination in cancer immunotherapy: More than one plus one. Leuk Res. 35:1136–1142. 2011. View Article : Google Scholar : PubMed/NCBI
8	Han RX, Liu X, Pan P, Jia YJ and Yu JC: Effectiveness and safety of chemotherapy combined with dendritic cells co-cultured with cytokine-induced killer cells in the treatment of advanced non-small-cell lung cancer: A systematic review and meta-analysis. PLoS One. 9:e1089582014. View Article : Google Scholar : PubMed/NCBI
9	Wray J, Morris CG, Kirwan JM, Amdur RJ, Werning JW, Dziegielewski PT and Mendenhall WM: Radiation therapy for nasal vestibule squamous cell carcinoma: A 40-year experience. Eur Arch Otorhinolaryngol. 2015 Mar 13;(Epub ahead of print). PubMed/NCBI
10	Jeannon JP, Riddle PJ, Irish J, O'sullivan B, Brown DH and Gullane P: Prognostic indicators in carcinoma of the nasal vestibule. Clin Otolaryngol. 32:19–23. 2007. View Article : Google Scholar : PubMed/NCBI
11	Kummer E, Rasch CR, Keus RB, Tan IB and Balm AJ: T stage as prognostic factor in irradiated localized squamous cell carcinoma of the nasal vestibule. Head Neck. 24:268–273. 2002. View Article : Google Scholar : PubMed/NCBI
12	Agger A, von Buchwald C, Madsen AR, Yde J, Lesnikova I, Christensen CB, Foghsgaard S, Christensen TB, Hansen HS, Larsen S, et al: Squamous cell carcinoma of the nasal vestibule 1993–2002: A nationwide retrospective study from DAHANCA. Head Neck. 31:1593–1599. 2009. View Article : Google Scholar : PubMed/NCBI
13	Wong CS, Cummings BJ, Elhakim T and Briant TD: External irradiation for squamous cell carcinoma of the nasal vestibule. Int J Radiat Oncol Biol Phys. 12:1943–1946. 1986. View Article : Google Scholar : PubMed/NCBI
14	Patel P, Tiwari R, Karim AB, Nauta JJ and Snow GB: Squamous cell carcinoma of the nasal vestibule. J Laryngol Otol. 106:332–336. 1992. View Article : Google Scholar : PubMed/NCBI
15	Fornelli RA, Fedok FG, Wilson EP and Rodman SM: Squamous cell carcinoma of the anterior nasal cavity: A dual institution review. Otolaryngol Head Neck Surg. 123:207–210. 2000. View Article : Google Scholar : PubMed/NCBI
16	Samaha M, Yoskovitch A, Hier MP and Black MJ: Squamous cell carcinoma of the nasal vestibule. J Otolaryngol. 29:98–101. 2000.PubMed/NCBI
17	Dowley A, Hoskison E, Allibone R and Jones NS: Squamous cell carcinoma of the nasal vestibule: A 20-year case series and literature review. J Laryngol Otol. 122:1019–1023. 2008. View Article : Google Scholar : PubMed/NCBI
18	Quinn FB Jr and Mccabe BF: Laryngeal metastases from malignant tumors in distant organs. Ann Otol Rhinol Laryngol. 66:139–143. 1957.PubMed/NCBI
19	Oien KA: Pathologic evaluation of unknown primary cancer. Semin Oncol. 36:8–37. 2009. View Article : Google Scholar : PubMed/NCBI
20	Huang YC, Chang PM, Lee IC, Yang CF, Tzeng CH and Yang MH: Duodenal squamous cell carcinoma derived from the hypopharynx: Immunohistochemical assessment of metastatic mechanisms. Gastrointest Endosc. 72:460–463. 2010. View Article : Google Scholar : PubMed/NCBI
21	Tabuchi T, Ito Y, Ioka A, Miyashiro I and Tsukuma H: Incidence of metachronous second primary cancers in Osaka, Japan: Update of analyses using population-based cancer registry data. Cancer Sci. 103:1111–1120. 2012. View Article : Google Scholar : PubMed/NCBI
22	Youlden DR and Baade PD: The relative risk of second primary cancers in Queensland, Australia: A retrospective cohort study. BMC Cancer. 11:832011. View Article : Google Scholar : PubMed/NCBI
23	Freeman HJ: Triple metachronous colon cancer. World J Gastroenterol. 19:4443–4444. 2013. View Article : Google Scholar : PubMed/NCBI
24	Rosso S, De Angelis R, Ciccolallo L, Carrani E, Soerjomataram I, Grande E, Zigon G and Brenner H: EUROCARE Working Group: Multiple tumours in survival estimates. Eur J Cancer. 45:1080–1094. 2009. View Article : Google Scholar : PubMed/NCBI
25	Utada M, Ohno Y, Hori M and Soda M: Incidence of multiple primary cancers and interval between first and second primary cancers. Cancer Sci. 105:890–896. 2014. View Article : Google Scholar : PubMed/NCBI
26	Filali K, Hédelin G, Schaffer P, Estève J, Arveux P, Bouchardy C, Exbrayat C, Faivre J, Lévi F, Macé-Lesech J, et al: Multiple primary cancers and estimation of the incidence rates and trends. Eur J Cancer. 32A:683–690. 1996. View Article : Google Scholar : PubMed/NCBI
27	Crocetti E, Buiatti E and Falini P: Italian Multiple Primary Cancer Working Group: Multiple primary cancer incidence in Italy. Eur J Cancer. 37:2449–2456. 2001. View Article : Google Scholar : PubMed/NCBI
28	Curtis RE, Boice JD Jr, Kleinerman RA, Flannery JT and Fraumeni JF Jr: Summary: Multiple primary cancers in Connecticut 1935–82. Natl Cancer Inst Monogr. 68:219–242. 1985.PubMed/NCBI
29	Ikeda Y, Tsukuda M, Ishitoya J, Arai Y, Matsuda H, Katori H, Taguchi T, Yoshida T, Ono M, Sakuma Y, et al: Four cases of simultaneous triple primary cancers of the hypopharynx, esophagus and stomach. Otolaryngol Head Neck Surg. 132:788–793. 2005. View Article : Google Scholar : PubMed/NCBI
30	Travis LB, Rabkin CS, Brown LM, Allan JM, Alter BP, Ambrosone CB, Begg CB, Caporaso N, Chanock S, DeMichele A, et al: Cancer survivorship - genetic susceptibility and second primary cancers: Research strategies and recommendations. J Natl Cancer Inst. 98:15–25. 2006. View Article : Google Scholar : PubMed/NCBI
31	Travis LB: The epidemiology of second primary cancers. Cancer Epidemiol Biomarkers Prev. 15:2020–2067. 2006. View Article : Google Scholar : PubMed/NCBI
32	Kuligina E, Reiner A, Imyanitov EN and Begg CB: Evaluating cancer epidemiologic risk factors using multiple primary malignancies. Epidemiology. 21:366–372. 2010. View Article : Google Scholar : PubMed/NCBI
33	Jiao F, Hu H and Wang LW: Quadruple primary malignancy patient with survival time more than 20 years. World J Gastroenterol. 19:1498–1501. 2013. View Article : Google Scholar : PubMed/NCBI
34	Adami HO, Hunter D and Trichopoulos D: Textbook of cancer epidemiology (2nd). Oxford University Press. New York: 2002.
35	Hiyama T, Sato T, Yoshino K, Tsukuma H, Hanai A and Fujimoto I: Second primary cancer following laryngeal cancer with special reference to smoking habits. Jpn J Cancer Res. 83:334–339. 1992. View Article : Google Scholar : PubMed/NCBI
36	Botteri E, Iodice S, Bagnardi V, Raimondi S, Lowenfels AB and Maisonneuve P: Smoking and colorectal cancer: A meta-analysis. JAMA. 300:2765–2778. 2008. View Article : Google Scholar : PubMed/NCBI
37	DeVita VT Jr and Rosenberg SA: Two hundred years of cancer research. N Engl J Med. 366:2207–2214. 2012. View Article : Google Scholar : PubMed/NCBI
38	Vital D, Morand G, Huber GF, Studer G and Holzmann D: Outcome in squamous cell carcinoma of the nasal vestibule: A single center experience. Head Neck. 37:46–51. 2015. View Article : Google Scholar : PubMed/NCBI