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Article

Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases

  • Authors:
    • Xingmei Guo
    • Nan Li
    • Kai Ren
    • Ligao Wu
    • Li Ma
    • Shiwu Wu
    • Fengmei Xie
    • Zhenzhong Feng
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College, Bengbu, Anhui 233000, P.R. China, Faculty of Pharmacy, Bengbu Medical College, Bengbu, Anhui 233004, P.R. China
  • Pages: 845-850
    |
    Published online on: March 7, 2016
       https://doi.org/10.3892/mco.2016.802
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Abstract

Solid pseudopapillary tumors (SPTs) are unusual neoplasms that mostly occur in the pancreas, and predominantly affect young women. As a low‑grade malignant neoplasm of the exocrine pancreas, they occasionally metastasize, usually to the liver or peritoneum. It has been reported that <1% of SPTs are primary extrapancreatic SPTs. In the present study, we present two rare, but conspicuous extrapancreatic SPTs. Both occurred in young women, and showed good prognoses following surgery. One was a recurrent SPT of the pancreas that metastasized to the ovary, and the other was a distinct primary neoplasm that arose in the retroperitoneal area. The pathological features of the two tumors, including solid and pseudopapillary growth patterns with pale or eosinophilic cytoplasm, were characteristic of SPTs of the pancreas. However, in the case of the metastatic ovarian tumor, focal necrosis and an increased nuclear‑to‑cytoplasmic ratio were observed. The presence of positive nuclear‑cytoplasmic β‑catenin, the loss of membranous E‑cadherin expression, and a perinuclear punctate CD99 staining pattern on immunohistochemistical analysis, were essential features for diagnosis. The aim of the present study was to compare the morphological and immunohistochemical features of these tumors with those typical of pancreatic SPTs, and to raise awareness that SPTs are able to metastasize to unusual sites, and may also arise as primary tumors outside the pancreas, which may lead to diagnostic dilemmas.
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1 

Zhu H, Xia D, Wang B and Meng H: Extrapancreatic solid pseudopapillary neoplasm: Report of a case of primary retroperitoneal origin and review of the literature. Oncol Lett. 5:1501–1504. 2013.PubMed/NCBI

2 

Frantz VK: Tumor of the pancreas. Atlas of Tumor Pathology. Bumberg CW: (1st). Armed Forces Institute of Pathology. (Washington). 32–33. 1959.

3 

Klöppel G, Solcia E, Longnecker DS, Capella C and Sobin LH: World Health Organization International Histological Classification of Tumours: Histological Typing of Tumors of the Exocrine Pancreas (2nd). Springer. Berlin: 15–21. 1996.

4 

Klöppel G, Hruban RH, Klimstra DS, et al: Solid-pseudopapillary tumor of pancreas. Bosman FT, Carneiro F, Hruban RH and Theise ND: World Health Organization classification of tumours of the digestive system. IARC. (Lyon). 327–330. 2010.

5 

Law JK, Ahmed A, Singh VK, Akshintala VS, Olson MT, Raman SP, Ali SZ, Fishman EK, Kamel I, Canto MI, et al: A systematic review of solid-pseudopapillary neoplasms: Are these rare lesions? Pancreas. 43:331–337. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Klöppel G, Maurer R, Hofmann E, Lüthold K, Oscarson J, Forsby N, Ihse I, Ljungberg O and Heitz PU: Solid-cystic (papillary-cystic) tumours within and outside the pancreas in men: Report of two patients. Virchows Arch A Pathol Anat Histopathol. 418:179–183. 1991. View Article : Google Scholar : PubMed/NCBI

7 

Miyazaki Y, Miyajima A, Maeda T, Yuge K, Hasegawa M, Kosaka T, Kikuchi E, Kameyama K, Jinzaki M, Nakagawa K and Oya M: Extrapancreatic solid pseudopapillary tumor: Case report and review of the literature. Int J Clin Oncol. 17:165–168. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Fukunaga M: Pseudopapillary solid cystic tumor arising from an extrapancreatic site. Arch Pathol Lab Med. 125:1368–1371. 2001.PubMed/NCBI

9 

Hibi T, Ojima H, Sakamoto Y, Kosuge T, Shimada K, Sano T, Sakamoto M, Kitajima M and Yamasaki S: A solid pseudopapillary tumor arising from the greater omentum followed by multiple metastases with increasing malignant potential. J Gastroenterol. 41:276–281. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Deshpande V, Oliva E and Young RH: Solid pseudopapillary neoplasm of the ovary: A report of 3 primary ovarian tumors resembling those of the pancreas. Am J Surg Pathol. 34:1514–1520. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Syriac S, Kesterson J, Izevbaye I, de Mesy Bentley KL, Lele S and Mhawech-Fauceglia P: Clinically aggressive primary solid pseudopapillary tumor of the ovary in a 45-year-old woman. Ann Diagn Pathol. 16:498–503. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Kominami A, Fujino M, Murakami H and Ito M: β-catenin mutation in ovarian solid pseudopapillary neoplasm. Pathol Int. 64:460–464. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Walter T, Hommell-Fontaine J, Hervieu V, Adham M, Poncet G, Dumortier J, Lombard-Bohas C and Scoazec JY: Primary malignant solid pseudopapillary tumors of the gastroduodenal area. Clin Res Hepatol Gastroenterol. 35:227–233. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Tajima Y, Kohara N, Maeda J, Inoue K, Kitasato A, Natsuda K, Irie J, Adachi T, Kuroki T, Eguchi S and Kanematsu T: Peritoneal and nodal recurrence 7 years after the excision of a ruptured solid pseudopapillary neoplasm of the pancreas: Report of a case. Surg Today. 42:776–780. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Papavramidis T and Papavramidis S: Solid pseudopapillary tumors of the pancreas: Review of 718 patients reported in English literature. J Am Coll Surg. 200:965–972. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Mete Ö, Yegen G, Güllüoglu MG, Kapran Y and Klöppel G: An unusual clinical presentation of pancreatic solid pseudopapillary tumor with ovarian metastases: A diagnostic dilemma. Int J Surg Pathol. 19:342–345. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Takahashi Y, Fukusato T, Aita K, Toida S, Fukushima J, Imamura T, Tanaka F, Amano H, Takada T and Mori S: Solid pseudopapillary tumor of the pancreas with metastases to the lung and liver. Pathol Int. 55:792–796. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Li L, Othman M, Rashid A and Wang H, Li Z, Katz MH, Lee JE, Pisters PW, Abbruzzese JL, Fleming JB and Wang H: Solid pseudopapillary neoplasm of the pancreas with prominent atypical multinucleated giant tumour cells. Histopathology. 62:465–467. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Tang LH, Aydin H, Brennan MF and Klimstra DS: Clinically aggressive solid pseudopapillary tumors of the pancreas: A report of two cases with components of undifferentiated carcinoma and a comparative clinicopathologic analysis of 34 conventional cases. Am J Surg Pathol. 29:512–519. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Bhatnagar R, Olson MT, Fishman EK, Hruban RH, Lennon AM and Ali SZ: Solid-pseudopapillary neoplasm of the pancreas: Cytomorphologic findings and literature review. Acta Cytol. 58:347–355. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Abraham SC, Klimstra DS, Wilentz RE, Yeo CJ, Conlon K, Brennan M, Cameron JL, Wu TT and Hruban RH: Solid-pseudopapillary tumors of the pancreas are genetically distinct from pancreatic ductal adenocarcinomas and almost always harbor beta-catenin mutations. Am J Pathol. 160:1361–1369. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Li L, Li J, Hao C, Zhang C, Mu K, Wang Y and Zhang T: Immunohistochemical evaluation of solid pseudopapillary tumors of the pancreas: The expression pattern of CD99 is highly unique. Cancer Lett. 310:9–144. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Geers C, Moulin P, Gigot JF, Weynand B, Deprez P, Rahier J and Sempoux C: Solid and pseudopapillary tumor of the pancreas-review and new insights into pathogenesis. Am J Surg Pathol. 30:1243–1239. 2006. View Article : Google Scholar : PubMed/NCBI

24 

Kosmahl M, Seada LS, Jänig U, Harms D and Klöppel G: Solid-pseudopapillary tumor of the pancreas: Its origin revisited. Virchows Arch. 436:473–480. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Van Thielen T, Degryse H and Coeman D: Yolk sac tumor of the ovary. JBR-BTR. 96:256–7. 2013.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Guo X, Li N, Ren K, Wu L, Ma L, Wu S, Xie F and Feng Z: Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases . Mol Clin Oncol 4: 845-850, 2016.
APA
Guo, X., Li, N., Ren, K., Wu, L., Ma, L., Wu, S. ... Feng, Z. (2016). Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases . Molecular and Clinical Oncology, 4, 845-850. https://doi.org/10.3892/mco.2016.802
MLA
Guo, X., Li, N., Ren, K., Wu, L., Ma, L., Wu, S., Xie, F., Feng, Z."Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases ". Molecular and Clinical Oncology 4.5 (2016): 845-850.
Chicago
Guo, X., Li, N., Ren, K., Wu, L., Ma, L., Wu, S., Xie, F., Feng, Z."Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases ". Molecular and Clinical Oncology 4, no. 5 (2016): 845-850. https://doi.org/10.3892/mco.2016.802
Copy and paste a formatted citation
x
Spandidos Publications style
Guo X, Li N, Ren K, Wu L, Ma L, Wu S, Xie F and Feng Z: Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases . Mol Clin Oncol 4: 845-850, 2016.
APA
Guo, X., Li, N., Ren, K., Wu, L., Ma, L., Wu, S. ... Feng, Z. (2016). Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases . Molecular and Clinical Oncology, 4, 845-850. https://doi.org/10.3892/mco.2016.802
MLA
Guo, X., Li, N., Ren, K., Wu, L., Ma, L., Wu, S., Xie, F., Feng, Z."Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases ". Molecular and Clinical Oncology 4.5 (2016): 845-850.
Chicago
Guo, X., Li, N., Ren, K., Wu, L., Ma, L., Wu, S., Xie, F., Feng, Z."Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases ". Molecular and Clinical Oncology 4, no. 5 (2016): 845-850. https://doi.org/10.3892/mco.2016.802
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