Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular and Clinical Oncology
Join Editorial Board Propose a Special Issue
Print ISSN: 2049-9450 Online ISSN: 2049-9469
Journal Cover
May-2016 Volume 4 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2016 Volume 4 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report Open Access

Response to chemotherapy with carboplatin plus albumin‑bound paclitaxel in a patient with lymphoepithelioma‑like thymic carcinoma: A case report

  • Authors:
    • Hiroshi Shima
    • Hiroaki Ozasa
    • Takahiro Tsuji
    • Hitomi Ajimizu
    • Takashi Nomizo
    • Yoshitaka Yagi
    • Yuichi Sakamori
    • Hiroki Nagai
    • Sachiko Minamiguchi
    • Young Hak Kim
    • Michiaki Mishima
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Kyoto University Graduate School of Medicine, Kyoto 606‑8507, Japan, Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto 606‑8507, Japan
    Copyright: © Shima et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 715-718
    |
    Published online on: March 7, 2016
       https://doi.org/10.3892/mco.2016.803
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Thymic carcinoma is a rare neoplasm with a poor outcome due to its aggressive characteristics. For patients who are not operable, radiation therapy and/or palliative chemotherapy are indicated. However, no optimal chemotherapy regimen has been established. The present study reports the case of a 22‑year‑old man with advanced lymphoepithelioma‑like thymic carcinoma refractory to conventional chemotherapy with carboplatin plus solvent‑based paclitaxel (sb‑PAC) treatment. The patient was subsequently treated with carboplatin plus nanoparticle albumin‑bound paclitaxel (nab‑PAC). The treatment resulted in a partial response following three cycles of chemotherapy. Since only grade 3 neutropenia, but no other severe adverse effects, was observed, no dose reduction was required. To the best of our knowledge, the current study is the first to present the response to chemotherapy with carboplatin plus nab‑PAC in a patient with lymphoepithelioma‑like thymic carcinoma. Considering that no standard treatment has been established in thymic carcinoma, nab‑PAC may merit further investigation in this rare, but aggressive disease.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Falkson CB, Bezjak A, Darling G, Gregg R, Malthaner R, Maziak DE, Yu E, Smith CA, McNair S, et al: The management of thymoma: A systematic review and practice guideline. J Thorac Oncol. 4:911–919. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Eng TY, Fuller CD, Jagirdar J, Bains Y and Thomas CR Jr: Thymic carcinoma: State of the art review. Int J Radiat Oncol Biol Phys. 59:654–664. 2004. View Article : Google Scholar : PubMed/NCBI

3 

NCCN guidelines on the treatment of thymomas and thymic carsinomas. Version 1. 2014.http://www.nccn.org/professionals/physician_gls/pdf/thymic.pdfAccessed. July 05–2015

4 

Desai N, Trieu V, Yao Z, Louie L, Ci S, Yang A, Tao C, De T, Beals B, Dykes D, et al: Increased antitumor activity, intratumor paclitaxel concentrations and endothelial cell transport of cremophor-free, albumin-bound paclitaxel, ABI-007, compared with cremophor-based paclitaxel. Clin Cancer Res. 12:1317–1324. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Socinski MA, Bondarenko I, Karaseva NA, Makhson AM, Vynnychenko I, Okamoto I, Hon JK, Hirsh V, Bhar P, Zhang H, et al: Weekly nab-paclitaxel in combination with carboplatin versus solvent-based paclitaxel plus carboplatin as first-line therapy in patients with advanced non-small-cell lung cancer: Final results of a phase III trial. J Clin Oncol. 30:2055–2062. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Gradishar WJ, Tjulandin S, Davidson N, Shaw H, Desai N, Bhar P, Hawkins M and O'Shaughnessy J: Phase III trial of nanoparticle albumin-bound paclitaxel compared with polyethylated castor oil-based paclitaxel in women with breast cancer. J Clin Oncol. 23:7794–7803. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Koizumi W, Morita S and Sakata Y: A randomized Phase III trial of weekly or 3-weekly doses of nab-paclitaxel versus weekly doses of Cremophor-based paclitaxel in patients with previously treated advanced gastric cancer (ABSOLUTE Trial). Jpn J Clin Oncol. 45:303–306. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Masaoka A, Monden Y, Nakahara K and Tanioka T: Follow-up study of thymomas with special reference to their clinical stages. Cancer. 48:2485–2492. 1981. View Article : Google Scholar : PubMed/NCBI

9 

Lemma GL, Lee JW, Aisner SC, Langer CJ, Tester WJ, Johnson DH and Loehrer PJ Sr: Phase II study of carboplatin and paclitaxel in advanced thymoma and thymic carcinoma. J Clin Oncol. 29:2060–2065. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Hirai F, Yamanaka T, Taguchi K, Daga H, Ono A, Tanaka K, Kogure Y, Shimizu J, Kimura T, Fukuoka J, et al: A multicenter phase II study of carboplatin and paclitaxel for advanced thymic carcinoma: WJOG4207L. Ann Oncol. 26:363–368. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Koizumi T, Takabayashi Y, Yamagishi S, Tsushima K, Takamizawa A, Tsukadaira A, Yamamoto H, Yamazaki Y, Yamaguchi S, Fujimoto K, et al: Chemotherapy for advanced thymic carcinoma: Clinical response to cisplatin, doxorubicin, vincristine and cyclophosphamide (ADOC chemotherapy). Am J Clin Oncol. 25:266–268. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Kanda S, Koizumi T, Komatsu Y, Yoshikawa S, Okada M, Hatayama O, Yasuo M, Tsushima K, Urushihata K, Kubo K, et al: Second-line chemotherapy of platinum compound plus CPT-11 following ADOC chemotherapy in advanced thymic carcinoma: Analysis of seven cases. Anticancer Res. 27:3005–3008. 2007.PubMed/NCBI

13 

Komatsu Y, Koizumi T, Tanabe T, Hatayama O, Yasuo M, Okada M, Yamamoto H, Kubo K, Sasabayashi M and Tsunoda T: Salvage chemotherapy with carboplatin and paclitaxel for cisplatin-resistant thymic carcinoma-three cases. Anticancer Res. 26:4851–4855. 2006.PubMed/NCBI

14 

Weide LG, Ulbright TM, Loehrer PJ Sr and Williams SD: Thymic carcinoma. A distinct clinical entity responsive to chemotherapy. Cancer. 71:1219–1223. 1993. View Article : Google Scholar : PubMed/NCBI

15 

Yoh K, Goto K, Ishii G, Niho S, Ohmatsu H, Kubota K, Kakinuma R, Nagai K, Suga M and Nishiwaki Y: Weekly chemotherapy with cisplatin, vincristine, doxorubicin and etoposide is an effective treatment for advanced thymic carcinoma. Cancer. 98:926–931. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Lucchi M, Mussi A, Ambrogi M, Gunfiotti A, Fontanini G, Basolo F and Angeletti CA: Thymic carcinoma: A report of 13 cases. Eur J Surg Oncol. 27:636–640. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Igawa S, Murakami H, Takahashi T, Nakamura Y, Tsuya A, Naito T, Kaira K, Ono A, Shukuya T, Tamiya A, et al: Efficacy of chemotherapy with carboplatin and paclitaxel for unresectable thymic carcinoma. Lung Cancer. 67:194–197. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Maruyama R, Suemitsu R, Okamoto T, Kojo M, Aoki Y, Wataya H, Eguchi T, Nishiyama K, Seto T and Ichinose Y: Persistent and aggressive treatment for thymic carcinoma. Results of a single-institute experience with 25 patients. Oncology. 70:325–329. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Leyvraz S, Henle W, Chahinian AP, Perlmann C, Klein G, Gordon RE, Rosenblum M and Holland JF: Association of Epstein-Barr virus with thymic carcinoma. N Engl J Med. 312:1296–1299. 1985. View Article : Google Scholar : PubMed/NCBI

20 

Schirosi L, Nannini N, Nicoli D, Cavazza A, Valli R, Buti S, Garagnani L, Sartori G, Calabrese F, Marchetti A, et al: Activating c-KIT mutations in a subset of thymic carcinoma and response to different c-KIT inhibitors. Ann Oncol. 23:2409–2414. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Kondo K and Monden Y: Therapy for thymic epithelial tumors: A clinical study of 1,320 patients from Japan. Ann Thorac Surg. 76:878–884; discussion 884–885. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Okuma Y, Hosomi Y, Takahashi S, Maeda Y, Okamura T and Hishima T: Response to cytotoxic chemotherapy in patients previously treated with palliative-intent chemotherapy for advanced thymic carcinoma. Clin Lung Cancer. 16:221–227. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Li W, Miao Z, Liu X, Zhang Q, Sun L, Li P, Liu W and Zhang L: Thymic carcinoma patients with myasthenia gravis exhibit better prognoses. Int J Clin Oncol. 2015 Jul 3;[Epub ahead of print].

24 

Filosso PL, Guerrera F, Rendina AE, Bora G, Ruffini E, Novero D, Ruco L, Vitolo D, Anile M, Ibrahim M, et al: Outcome of surgically resected thymic carcinoma: A multicenter experience. Lung Cancer. 83:205–210. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Wang S, Wang Z, Liu X, Wang D and Liu F: Prognostic factors of patients with thymic carcinoma after surgery: A retrospective analysis of 58 cases. World J Surg. 38:2032–2038. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Makimoto G, Fujiwara K, Watanabe H, Kameyama N, Matsushita M, Rai K, Sato K, Yonei T, Sato T and Shibayama T: nab-Paclitaxel in combination with carboplatin for a previously treated thymic carcinoma. Case Rep Oncol. 7:14–17. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Zhan P, Xie H and Yu LK: Response to nab-paclitaxel and nedaplatin in a heavily-metastatic thymic carcinoma: A case report. Oncol Lett. 9:1715–1718. 2015.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Shima H, Ozasa H, Tsuji T, Ajimizu H, Nomizo T, Yagi Y, Sakamori Y, Nagai H, Minamiguchi S, Kim YH, Kim YH, et al: Response to chemotherapy with carboplatin plus albumin‑bound paclitaxel in a patient with lymphoepithelioma‑like thymic carcinoma: A case report. Mol Clin Oncol 4: 715-718, 2016.
APA
Shima, H., Ozasa, H., Tsuji, T., Ajimizu, H., Nomizo, T., Yagi, Y. ... Mishima, M. (2016). Response to chemotherapy with carboplatin plus albumin‑bound paclitaxel in a patient with lymphoepithelioma‑like thymic carcinoma: A case report. Molecular and Clinical Oncology, 4, 715-718. https://doi.org/10.3892/mco.2016.803
MLA
Shima, H., Ozasa, H., Tsuji, T., Ajimizu, H., Nomizo, T., Yagi, Y., Sakamori, Y., Nagai, H., Minamiguchi, S., Kim, Y. H., Mishima, M."Response to chemotherapy with carboplatin plus albumin‑bound paclitaxel in a patient with lymphoepithelioma‑like thymic carcinoma: A case report". Molecular and Clinical Oncology 4.5 (2016): 715-718.
Chicago
Shima, H., Ozasa, H., Tsuji, T., Ajimizu, H., Nomizo, T., Yagi, Y., Sakamori, Y., Nagai, H., Minamiguchi, S., Kim, Y. H., Mishima, M."Response to chemotherapy with carboplatin plus albumin‑bound paclitaxel in a patient with lymphoepithelioma‑like thymic carcinoma: A case report". Molecular and Clinical Oncology 4, no. 5 (2016): 715-718. https://doi.org/10.3892/mco.2016.803
Copy and paste a formatted citation
x
Spandidos Publications style
Shima H, Ozasa H, Tsuji T, Ajimizu H, Nomizo T, Yagi Y, Sakamori Y, Nagai H, Minamiguchi S, Kim YH, Kim YH, et al: Response to chemotherapy with carboplatin plus albumin‑bound paclitaxel in a patient with lymphoepithelioma‑like thymic carcinoma: A case report. Mol Clin Oncol 4: 715-718, 2016.
APA
Shima, H., Ozasa, H., Tsuji, T., Ajimizu, H., Nomizo, T., Yagi, Y. ... Mishima, M. (2016). Response to chemotherapy with carboplatin plus albumin‑bound paclitaxel in a patient with lymphoepithelioma‑like thymic carcinoma: A case report. Molecular and Clinical Oncology, 4, 715-718. https://doi.org/10.3892/mco.2016.803
MLA
Shima, H., Ozasa, H., Tsuji, T., Ajimizu, H., Nomizo, T., Yagi, Y., Sakamori, Y., Nagai, H., Minamiguchi, S., Kim, Y. H., Mishima, M."Response to chemotherapy with carboplatin plus albumin‑bound paclitaxel in a patient with lymphoepithelioma‑like thymic carcinoma: A case report". Molecular and Clinical Oncology 4.5 (2016): 715-718.
Chicago
Shima, H., Ozasa, H., Tsuji, T., Ajimizu, H., Nomizo, T., Yagi, Y., Sakamori, Y., Nagai, H., Minamiguchi, S., Kim, Y. H., Mishima, M."Response to chemotherapy with carboplatin plus albumin‑bound paclitaxel in a patient with lymphoepithelioma‑like thymic carcinoma: A case report". Molecular and Clinical Oncology 4, no. 5 (2016): 715-718. https://doi.org/10.3892/mco.2016.803
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team