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Distinct epithelial growth factor receptor mutation profile in non-small‑cell lung cancer patients from the Xuanwei area of China

  • Authors:
    • Yun Chen
    • Lijuan Ye
    • Rebecca Rongrong Stanford
    • Dongfang Zhang
    • Xingsong Zhang
    • Wanli Wei
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Yunnan Provincial Tumor Hospital, Kunming, Yunnan 650100, P.R. China, Department of Life Sciences, Imperial College London, London SW7 2AZ, UK
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 749-755
    |
    Published online on: March 7, 2016
       https://doi.org/10.3892/mco.2016.805
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Abstract

The Xuanwei county in China has a high incidence of lung cancer and related mortality. Previous studies have suggested that these cases may be associated with a distinctive pattern of mutations in the epithelial growth factor receptor (EGFR) gene. In this retrospective study, we investigated the mutation profile of EGFR in non-small‑cell lung cancer (NSCLC) tissues from patients in Xuanwei, and the associated clinicopathological characteristics. Specimens from 258 consecutive patients with lung cancer (90 from Xuanwei and 168 from other areas of Yunnan province) were subjected to amplification refractory mutation system‑polymerase chain reaction (ARMS-PCR) to detect EGFR mutations. In 67 specimens from Xuanwei, the results were confirmed by direct DNA sequencing for EGFR mutations. Immunohistochemistry (IHC) for the echinoderm microtubule-associated protein‑like 4-anaplastic lymphoma kinase (EML4-ALK) fusion protein was performed on all specimens from Xuanwei. We observed that Xuanwei patients presented with distinctive clinicopathological characteristics, including female gender predominance, younger age, higher rate of lymph node metastasis, higher rate of adenocarcinoma histological classification and lower disease stage, and a low rate of the ‘classical’ mutations on EGFR exons 19 and 21 compared with non‑Xuanwei patients (7.8 and 21.6% vs. 49.3 and 39.7%, respectively; P<0.05 for combined data). However, a significantly higher percentage of Xuanwei patients harbored co-mutation of EGFR exons 18 and 20 compared with non‑Xuanwei patients (45.1 vs. 4.1%, respectively; P<0.0001). Specimens from 2 Xuanwei patients (2.2%) were positive for the EML4-ALK fusion protein; by IHC, neither harbored EGFR mutations. There was no obvious association between EGFR mutations and disease stage or lymph node involvement. Thus, NSCLC patients in Xuanwei presented with a unique EGFR profile of high rates of co-mutation of exons 18 and 20, and low rates of exon 19 or 21 mutations when compared with patients from other areas in the same province, whereas only few of the tumors from Xuanwei patients expressed the EML4-ALK oncogene.
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1 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ: Cancer statistics, 2007. CA Cancer J Clin. 57:43–66. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Buettner R, Wolf J and Thomas RK: Lessons learned from lung cancer genomics: The emerging concept of individualized diagnostics and treatment. J Clin Oncol. 31:1858–1865. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Normanno N, Maiello MR and De Luca A: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs): Simple drugs with a complex mechanism of action? J Cell Physiol. 194:13–19. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, et al: North-East Japan Study Group: Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med. 362:2380–2388. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, Palmero R, Garcia-Gomez R, Pallares C, Sanchez JM, et al: Spanish Lung Cancer Group in collaboration with Groupe Français de Pneumo-Cancérologie and Associazione Italiana Oncologia Toracica: Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial. Lancet Oncol. 13:239–246. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Hosgood HD III, Pao W, Rothman N, Hu W, Pan YH, Kuchinsky K, Jones KD, Xu J, Vermeulen R, Simko J, et al: Driver mutations among never smoking female lung cancer tissues in China identify unique EGFR and KRAS mutation pattern associated with household coal burning. Respir Med. 107:1755–1762. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Shigematsu H and Gazdar AF: Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers. Int J Cancer. 118:257–262. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Sun Y, Ren Y, Fang Z, Li C, Fang R, Gao B, Han X, Tian W, Pao W, Chen H, et al: Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases. J Clin Oncol. 28:4616–4620. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Wong DW, Leung EL, So KK, Tam IY, Sihoe AD, Cheng LC, Ho KK, Au JS, Chung LP and Wong Pik M: University of Hong Kong Lung Cancer Study Group: The EML4-ALK fusion gene is involved in various histologic types of lung cancers from nonsmokers with wild-type EGFR and KRAS. Cancer. 115:1723–1733. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, et al: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 131:1190–1203. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Takeuchi K, Choi YL, Togashi Y, Soda M, Hatano S, Inamura K, Takada S, Ueno T, Yamashita Y, Satoh Y, et al: KIF5B-ALK, a novel fusion oncokinase identified by an immunohistochemistry-based diagnostic system for ALK-positive lung cancer. Clin Cancer Res. 15:3143–3149. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Siegelin MD and Borczuk AC: Epidermal growth factor receptor mutations in lung adenocarcinoma. Lab Invest. 94:129–137. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Wang Y, Wang S, Xu S, Qu J and Liu B: Clinicopathologic features of patients with non-small cell lung cancer harboring the EML4-ALK fusion gene: A meta-analysis. PLoS One. 9:e1106172014. View Article : Google Scholar : PubMed/NCBI

15 

Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, et al: EGF receptor gene mutations are common in lung cancers from ‘never smokers’ and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci USA. 101:13306–13311. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Sharma SV, Bell DW, Settleman J and Haber DA: Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer. 7:169–181. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Ye L, Stanford RR, Zhang D, Zhang X and Wei W: Distinct epithelial growth factor receptor mutation profile in non-small‑cell lung cancer patients from the Xuanwei area of China. Mol Clin Oncol 4: 749-755, 2016.
APA
Chen, Y., Ye, L., Stanford, R.R., Zhang, D., Zhang, X., & Wei, W. (2016). Distinct epithelial growth factor receptor mutation profile in non-small‑cell lung cancer patients from the Xuanwei area of China. Molecular and Clinical Oncology, 4, 749-755. https://doi.org/10.3892/mco.2016.805
MLA
Chen, Y., Ye, L., Stanford, R. R., Zhang, D., Zhang, X., Wei, W."Distinct epithelial growth factor receptor mutation profile in non-small‑cell lung cancer patients from the Xuanwei area of China". Molecular and Clinical Oncology 4.5 (2016): 749-755.
Chicago
Chen, Y., Ye, L., Stanford, R. R., Zhang, D., Zhang, X., Wei, W."Distinct epithelial growth factor receptor mutation profile in non-small‑cell lung cancer patients from the Xuanwei area of China". Molecular and Clinical Oncology 4, no. 5 (2016): 749-755. https://doi.org/10.3892/mco.2016.805
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Ye L, Stanford RR, Zhang D, Zhang X and Wei W: Distinct epithelial growth factor receptor mutation profile in non-small‑cell lung cancer patients from the Xuanwei area of China. Mol Clin Oncol 4: 749-755, 2016.
APA
Chen, Y., Ye, L., Stanford, R.R., Zhang, D., Zhang, X., & Wei, W. (2016). Distinct epithelial growth factor receptor mutation profile in non-small‑cell lung cancer patients from the Xuanwei area of China. Molecular and Clinical Oncology, 4, 749-755. https://doi.org/10.3892/mco.2016.805
MLA
Chen, Y., Ye, L., Stanford, R. R., Zhang, D., Zhang, X., Wei, W."Distinct epithelial growth factor receptor mutation profile in non-small‑cell lung cancer patients from the Xuanwei area of China". Molecular and Clinical Oncology 4.5 (2016): 749-755.
Chicago
Chen, Y., Ye, L., Stanford, R. R., Zhang, D., Zhang, X., Wei, W."Distinct epithelial growth factor receptor mutation profile in non-small‑cell lung cancer patients from the Xuanwei area of China". Molecular and Clinical Oncology 4, no. 5 (2016): 749-755. https://doi.org/10.3892/mco.2016.805
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