Prevalence and treatment of small intestinal bacterial overgrowth in postoperative patients with colorectal cancer

Deng,Lihua; Liu,Yang; Zhang,Dongsheng; Li,Yuan; Xu,Lin

doi:10.3892/mco.2016.807

May-2016 Volume 4 Issue 5

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May-2016 Volume 4 Issue 5

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Article

Prevalence and treatment of small intestinal bacterial overgrowth in postoperative patients with colorectal cancer

Authors:
- Lihua Deng
- Yang Liu
- Dongsheng Zhang
- Yuan Li
- Lin Xu
View Affiliations / Copyright

Affiliations: Department of Gastroenterology, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, Shandong 266071, P.R. China, Department of Hepatobiliary Surgery, Qingdao Municipal Hospital Affiliated to Qingdao University, Qingdao, Shandong 266071, P.R. China
Pages: 883-887
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Published online on: March 7, 2016

https://doi.org/10.3892/mco.2016.807
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Abstract

To investigate the prevalence of small intestinal bacterial overgrowth (SIBO) in patients with colorectal cancer (CRC) after surgical treatment and observe whether gastrointestinal symptoms may improve with rifaximin, 43 postoperative CRC patients (CRC group) and 30 healthy individuals (normal group) were subjected to the glucose hydrogen breath test (GHBT). All the patients were asked to evaluate the gastrointestinal symptoms using the visual analogue scale (VAS). SIBO‑positive patients were administered rifaximin for 10 days on the basis of the original treatment. After the treatment, the patients were asked to undergo GHBT and re-evaluate the gastrointestinal symptoms score (GISS). The results demonstrated that 18 of the 43 postoperative patients with CRC were SIBO‑positive (41.86%), which was significantly higher compared with the incidence in normal controls (6.67%) (P<0.05). GISS was higher in SIbO‑positive patients (P<0.05). Following rifaximin treatment, 6 of the 18 (33.33%) SIBO‑positive patients had improved, as evaluated by GHBT and VAS. Additionally, the GISS in the SIBO‑turned‑negative group had improved significantly compared with that in the non‑turned‑negative group (P<0.05). The symptoms of all 18 SIBO‑positive patients following rifaximin treatment improved notably, particularly diarrhea (P<0.05). In conclusion, postoperative CRC patients are more likely to develop SIBO compared with healthy individuals, and SIBO may aggravate digestive symptoms. The administration of rifaximin improved the overall gastrointestinal symptoms, particularly diarrhea, in SIBO‑positive patients.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Prevalence and treatment of small intestinal bacterial overgrowth in postoperative patients with colorectal cancer

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