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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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May-2016 Volume 4 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Case Report Open Access

Malignant myoepithelioma of the breast: a case report and review of the literature

  • Authors:
    • Maria Papazian
    • Ioannis Kalantzis
    • Georgios Galanopoulos
    • Iliana Mani
    • Olympia Tzaida
    • Ioanna Iacovidou
    • Nikolaos Ziras
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, ‘METAXA’ Anticancer Hospital, 18537 Piraeus, Greece, Department of Oncology, ‘METAXA’ Anticancer Hospital, 18537 Piraeus, Greece
    Copyright: © Papazian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 723-727
    |
    Published online on: March 7, 2016
       https://doi.org/10.3892/mco.2016.808
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Abstract

Malignant myoepithelioma of the breast is an extremely rare tumor composed entirely or almost entirely of malignant spindle cells with myoepithelial differentiation. Only a limited number of case reports have been descibed to date; therefore the biological behavior and treatment outcomes of this rare tumor have not been clearly determined. Herein, we present a case of a 74‑year‑old woman who was admitted with inflammatory‑like cancer of the breast, presenting with invasion of the chest wall and axillary lymph node metastasis at the time of diagnosis. The histological examination revealed a tumor composed of epithelioid and spindle cells with moderate to marked nuclear atypia, with foci of hemorrhage and necrosis. The tumor cells were immunoreactive for vimentin, p63, p53, CD10, cytokeratin (CK)8̸18, CKAE1‑3 and S‑100. Finally, a diagnosis of myoepithelial carcinoma of the breast was established. Neoadjuvant chemotherapy was first administered and proved to be ineffective. Due to locoregional progression that was associated with the development of an abscess and subsequent excessive bleeding, a palliative mastectomy was performed. Postoperatively, one more cycle of systemic chemotherapy was administered. However, the patient experienced an early relapse to the chest wall and succumbed to septic shock due to persistent local infection. The aggressiveness and chemoresistance of the tumor in this case was consistent with the existing bibliography.
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Copy and paste a formatted citation
Spandidos Publications style
Papazian M, Kalantzis I, Galanopoulos G, Mani I, Tzaida O, Iacovidou I and Ziras N: Malignant myoepithelioma of the breast: a case report and review of the literature. Mol Clin Oncol 4: 723-727, 2016.
APA
Papazian, M., Kalantzis, I., Galanopoulos, G., Mani, I., Tzaida, O., Iacovidou, I., & Ziras, N. (2016). Malignant myoepithelioma of the breast: a case report and review of the literature. Molecular and Clinical Oncology, 4, 723-727. https://doi.org/10.3892/mco.2016.808
MLA
Papazian, M., Kalantzis, I., Galanopoulos, G., Mani, I., Tzaida, O., Iacovidou, I., Ziras, N."Malignant myoepithelioma of the breast: a case report and review of the literature". Molecular and Clinical Oncology 4.5 (2016): 723-727.
Chicago
Papazian, M., Kalantzis, I., Galanopoulos, G., Mani, I., Tzaida, O., Iacovidou, I., Ziras, N."Malignant myoepithelioma of the breast: a case report and review of the literature". Molecular and Clinical Oncology 4, no. 5 (2016): 723-727. https://doi.org/10.3892/mco.2016.808
Copy and paste a formatted citation
x
Spandidos Publications style
Papazian M, Kalantzis I, Galanopoulos G, Mani I, Tzaida O, Iacovidou I and Ziras N: Malignant myoepithelioma of the breast: a case report and review of the literature. Mol Clin Oncol 4: 723-727, 2016.
APA
Papazian, M., Kalantzis, I., Galanopoulos, G., Mani, I., Tzaida, O., Iacovidou, I., & Ziras, N. (2016). Malignant myoepithelioma of the breast: a case report and review of the literature. Molecular and Clinical Oncology, 4, 723-727. https://doi.org/10.3892/mco.2016.808
MLA
Papazian, M., Kalantzis, I., Galanopoulos, G., Mani, I., Tzaida, O., Iacovidou, I., Ziras, N."Malignant myoepithelioma of the breast: a case report and review of the literature". Molecular and Clinical Oncology 4.5 (2016): 723-727.
Chicago
Papazian, M., Kalantzis, I., Galanopoulos, G., Mani, I., Tzaida, O., Iacovidou, I., Ziras, N."Malignant myoepithelioma of the breast: a case report and review of the literature". Molecular and Clinical Oncology 4, no. 5 (2016): 723-727. https://doi.org/10.3892/mco.2016.808
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