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Molecular and Clinical Oncology
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

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Article

Bevacizumab treatment for newly diagnosed glioblastoma: Systematic review and meta-analysis of clinical trials

  • Authors:
    • Peng Fu
    • Yun-Song He
    • Qin Huang
    • Tao Ding
    • Yong-Cun Cen
    • Hong-Yang Zhao
    • Xiang Wei
  • View Affiliations / Copyright

    Affiliations: Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
  • Pages: 833-838
    |
    Published online on: March 10, 2016
       https://doi.org/10.3892/mco.2016.816
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Abstract

High-grade glioma is a richly neovascularized brain solid tumor with a poor prognosis. Bevacizumab is a recombinant humanized monoclonal antibody that inhibits vascular endothelial cell proliferation and angiogenesis, which has shown clinical efficacy in recurrent glioblastoma. MEDLINE/PubMed, EMBASE and Web of Science databases were searched for relevant studies that compared bevacizumab plus combined radiotherapy/temozolomide (RT/TMZ) with RT/TMZ alone in newly diagnosed glioblastoma (GBM). Of all the studies identified, three comparative trials were included in the systematic review. All three enrolling trials, including a total of 1,738 patients, investigated bevacizumab or placebo plus combined RT/TMZ treatment in glioblastoma. The result showed no increased overall survival (OS) (pooled hazard ratio (HR), 1.04; 95% confidence interval (CI), 0.84‑1.29; P=0.71) but increased progression‑free survival (HR, 0.74; 95% CI, 0.62‑0.88; P=0.0009). However, the two randomized double‑blind placebo‑control trials exemplified a high rate of adverse events of the bevacizumab compared with the placebo group while discrepant points were noted in term of quality-of-life outcome. Additionally, bevacizumab plus RT/TMZ did not increase the 6‑month survival rate [odd ratios (ORs), 0.65; 95% CI, 0.37‑1.13; P=0.13). Overall, addition of bevacizumab to radiotherapy-temozolomide treatment may be an effective therapy strategy for improving progression-free survival. OS and the 6‑month survival rate was not prolonged and there was questionable efficacy of bevacizumab on the quality-of-life of glioblastoma patients, thus further clinical trials should be performed.
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Copy and paste a formatted citation
Spandidos Publications style
Fu P, He Y, Huang Q, Ding T, Cen Y, Zhao H and Wei X: Bevacizumab treatment for newly diagnosed glioblastoma: Systematic review and meta-analysis of clinical trials. Mol Clin Oncol 4: 833-838, 2016.
APA
Fu, P., He, Y., Huang, Q., Ding, T., Cen, Y., Zhao, H., & Wei, X. (2016). Bevacizumab treatment for newly diagnosed glioblastoma: Systematic review and meta-analysis of clinical trials. Molecular and Clinical Oncology, 4, 833-838. https://doi.org/10.3892/mco.2016.816
MLA
Fu, P., He, Y., Huang, Q., Ding, T., Cen, Y., Zhao, H., Wei, X."Bevacizumab treatment for newly diagnosed glioblastoma: Systematic review and meta-analysis of clinical trials". Molecular and Clinical Oncology 4.5 (2016): 833-838.
Chicago
Fu, P., He, Y., Huang, Q., Ding, T., Cen, Y., Zhao, H., Wei, X."Bevacizumab treatment for newly diagnosed glioblastoma: Systematic review and meta-analysis of clinical trials". Molecular and Clinical Oncology 4, no. 5 (2016): 833-838. https://doi.org/10.3892/mco.2016.816
Copy and paste a formatted citation
x
Spandidos Publications style
Fu P, He Y, Huang Q, Ding T, Cen Y, Zhao H and Wei X: Bevacizumab treatment for newly diagnosed glioblastoma: Systematic review and meta-analysis of clinical trials. Mol Clin Oncol 4: 833-838, 2016.
APA
Fu, P., He, Y., Huang, Q., Ding, T., Cen, Y., Zhao, H., & Wei, X. (2016). Bevacizumab treatment for newly diagnosed glioblastoma: Systematic review and meta-analysis of clinical trials. Molecular and Clinical Oncology, 4, 833-838. https://doi.org/10.3892/mco.2016.816
MLA
Fu, P., He, Y., Huang, Q., Ding, T., Cen, Y., Zhao, H., Wei, X."Bevacizumab treatment for newly diagnosed glioblastoma: Systematic review and meta-analysis of clinical trials". Molecular and Clinical Oncology 4.5 (2016): 833-838.
Chicago
Fu, P., He, Y., Huang, Q., Ding, T., Cen, Y., Zhao, H., Wei, X."Bevacizumab treatment for newly diagnosed glioblastoma: Systematic review and meta-analysis of clinical trials". Molecular and Clinical Oncology 4, no. 5 (2016): 833-838. https://doi.org/10.3892/mco.2016.816
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